Long non-coding RNA HAGLR: The potential biomarker plays an important role in idiopathic pulmonary fibrosis

•This is the first study to investigate the role of lncRNA HAGLR in IPF.•HAGLR can distinguish IPF from other pulmonary diseases.•HAGLR can influence the fibrosis process at the cellular level. Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, has a severe prognosis, an...

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Vydáno v:	Gene Ročník 966; s. 149717
Hlavní autoři:	Hu, Lijuan, Liu, Ruoyu, Han, Siqi, Zhang, Ruyue, Zhou, Yun, Cao, Yongtong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 20.09.2025
Témata:	Aged Biomarker Biomarkers - blood Biomarkers - metabolism Case-Control Studies Female Humans Idiopathic pulmonary fibrosis Idiopathic Pulmonary Fibrosis - blood Idiopathic Pulmonary Fibrosis - diagnosis Idiopathic Pulmonary Fibrosis - genetics Male Middle Aged Non-coding RNA RNA, Long Noncoding - blood RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism ROC Curve ILD Biomarker Idiopathic pulmonary fibrosis LncRNA CDNA TNF AUC IFN-α IFN-γ ANOVA CA15-3 CA125 WBC HRCT GSE231693 CEA HAGLR NSE HGB IL HFL-1 CI ROC qRT-PCR TBST KL-6 Pro-GRP Cyfra21-1 GEO COL1A1 IIP SCC COL3A1 ShRNA NC TGF-β1 Non-coding RNA UIP GAPDH IPF
ISSN:	0378-1119, 1879-0038, 1879-0038
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Abstract	•This is the first study to investigate the role of lncRNA HAGLR in IPF.•HAGLR can distinguish IPF from other pulmonary diseases.•HAGLR can influence the fibrosis process at the cellular level. Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, has a severe prognosis, and its diagnosis is difficult. Long non-coding RNAs (lncRNAs) play crucial roles in the mechanism of IPF and exhibit great potential as biomarkers. Past research found that HOXD antisense growth-associated lncRNA (HAGLR) was elevated in IPF. Therefore, this study assessed the diagnostic utility and function of HAGLR in IPF. HAGLR expression was screened in the Gene Expression Omnibus datasets. Then, the serum specimens and clinical information of 66 patients with IPF, 93 patients with interstitial lung disease (ILD) without IPF, 61 patients with pneumonia, and 58 healthy controls were simultaneously collected. HAGLR expression was tested in all subjects and analyzed using receiver operating characteristic curves to verify the clinical utility of HAGLR. Then, the effects of HAGLR inhibition on fibrosis-related gene and protein expression in a cell model of fibrosis were investigated by quantitative reverse transcription-polymerase chain reaction and western blotting. HAGLR expression was higher in patients with IPF than in healthy controls, patients with ILD without IPF, and patients with pneumonia. The ROC curve analysis illustrated that HAGLR can distinguish patients with IPF from healthy controls. A model combining clinical items (including age, gender, routine blood test, tumor biomarkers, and cytokines), with HAGLR displayed good clinical value, with an are under the curve of 0.994, sensitivity of 100.0% and specificity of 91.4%. Upon HAGLR inhibition, fibrosis proteins were downregulated. HAGLR has utility in the auxiliary diagnosis of IPF, as it can differentiate IPF from other conditions. HAGLR inhibition could alleviate fibrosis at the cellular level.
AbstractList	Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, has a severe prognosis, and its diagnosis is difficult. Long non-coding RNAs (lncRNAs) play crucial roles in the mechanism of IPF and exhibit great potential as biomarkers. Past research found that HOXD antisense growth-associated lncRNA (HAGLR) was elevated in IPF. Therefore, this study assessed the diagnostic utility and function of HAGLR in IPF.BACKGROUNDIdiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, has a severe prognosis, and its diagnosis is difficult. Long non-coding RNAs (lncRNAs) play crucial roles in the mechanism of IPF and exhibit great potential as biomarkers. Past research found that HOXD antisense growth-associated lncRNA (HAGLR) was elevated in IPF. Therefore, this study assessed the diagnostic utility and function of HAGLR in IPF.HAGLR expression was screened in the Gene Expression Omnibus datasets. Then, the serum specimens and clinical information of 66 patients with IPF, 93 patients with interstitial lung disease (ILD) without IPF, 61 patients with pneumonia, and 58 healthy controls were simultaneously collected. HAGLR expression was tested in all subjects and analyzed using receiver operating characteristic curves to verify the clinical utility of HAGLR. Then, the effects of HAGLR inhibition on fibrosis-related gene and protein expression in a cell model of fibrosis were investigated by quantitative reverse transcription-polymerase chain reaction and western blotting.METHODHAGLR expression was screened in the Gene Expression Omnibus datasets. Then, the serum specimens and clinical information of 66 patients with IPF, 93 patients with interstitial lung disease (ILD) without IPF, 61 patients with pneumonia, and 58 healthy controls were simultaneously collected. HAGLR expression was tested in all subjects and analyzed using receiver operating characteristic curves to verify the clinical utility of HAGLR. Then, the effects of HAGLR inhibition on fibrosis-related gene and protein expression in a cell model of fibrosis were investigated by quantitative reverse transcription-polymerase chain reaction and western blotting.HAGLR expression was higher in patients with IPF than in healthy controls, patients with ILD without IPF, and patients with pneumonia. The ROC curve analysis illustrated that HAGLR can distinguish patients with IPF from healthy controls. A model combining clinical items (including age, gender, routine blood test, tumor biomarkers, and cytokines), with HAGLR displayed good clinical value, with an are under the curve of 0.994, sensitivity of 100.0% and specificity of 91.4%. Upon HAGLR inhibition, fibrosis proteins were downregulated.RESULTSHAGLR expression was higher in patients with IPF than in healthy controls, patients with ILD without IPF, and patients with pneumonia. The ROC curve analysis illustrated that HAGLR can distinguish patients with IPF from healthy controls. A model combining clinical items (including age, gender, routine blood test, tumor biomarkers, and cytokines), with HAGLR displayed good clinical value, with an are under the curve of 0.994, sensitivity of 100.0% and specificity of 91.4%. Upon HAGLR inhibition, fibrosis proteins were downregulated.HAGLR has utility in the auxiliary diagnosis of IPF, as it can differentiate IPF from other conditions. HAGLR inhibition could alleviate fibrosis at the cellular level.CONCLUSIONHAGLR has utility in the auxiliary diagnosis of IPF, as it can differentiate IPF from other conditions. HAGLR inhibition could alleviate fibrosis at the cellular level. Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, has a severe prognosis, and its diagnosis is difficult. Long non-coding RNAs (lncRNAs) play crucial roles in the mechanism of IPF and exhibit great potential as biomarkers. Past research found that HOXD antisense growth-associated lncRNA (HAGLR) was elevated in IPF. Therefore, this study assessed the diagnostic utility and function of HAGLR in IPF. HAGLR expression was screened in the Gene Expression Omnibus datasets. Then, the serum specimens and clinical information of 66 patients with IPF, 93 patients with interstitial lung disease (ILD) without IPF, 61 patients with pneumonia, and 58 healthy controls were simultaneously collected. HAGLR expression was tested in all subjects and analyzed using receiver operating characteristic curves to verify the clinical utility of HAGLR. Then, the effects of HAGLR inhibition on fibrosis-related gene and protein expression in a cell model of fibrosis were investigated by quantitative reverse transcription-polymerase chain reaction and western blotting. HAGLR expression was higher in patients with IPF than in healthy controls, patients with ILD without IPF, and patients with pneumonia. The ROC curve analysis illustrated that HAGLR can distinguish patients with IPF from healthy controls. A model combining clinical items (including age, gender, routine blood test, tumor biomarkers, and cytokines), with HAGLR displayed good clinical value, with an are under the curve of 0.994, sensitivity of 100.0% and specificity of 91.4%. Upon HAGLR inhibition, fibrosis proteins were downregulated. HAGLR has utility in the auxiliary diagnosis of IPF, as it can differentiate IPF from other conditions. HAGLR inhibition could alleviate fibrosis at the cellular level. •This is the first study to investigate the role of lncRNA HAGLR in IPF.•HAGLR can distinguish IPF from other pulmonary diseases.•HAGLR can influence the fibrosis process at the cellular level. Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, has a severe prognosis, and its diagnosis is difficult. Long non-coding RNAs (lncRNAs) play crucial roles in the mechanism of IPF and exhibit great potential as biomarkers. Past research found that HOXD antisense growth-associated lncRNA (HAGLR) was elevated in IPF. Therefore, this study assessed the diagnostic utility and function of HAGLR in IPF. HAGLR expression was screened in the Gene Expression Omnibus datasets. Then, the serum specimens and clinical information of 66 patients with IPF, 93 patients with interstitial lung disease (ILD) without IPF, 61 patients with pneumonia, and 58 healthy controls were simultaneously collected. HAGLR expression was tested in all subjects and analyzed using receiver operating characteristic curves to verify the clinical utility of HAGLR. Then, the effects of HAGLR inhibition on fibrosis-related gene and protein expression in a cell model of fibrosis were investigated by quantitative reverse transcription-polymerase chain reaction and western blotting. HAGLR expression was higher in patients with IPF than in healthy controls, patients with ILD without IPF, and patients with pneumonia. The ROC curve analysis illustrated that HAGLR can distinguish patients with IPF from healthy controls. A model combining clinical items (including age, gender, routine blood test, tumor biomarkers, and cytokines), with HAGLR displayed good clinical value, with an are under the curve of 0.994, sensitivity of 100.0% and specificity of 91.4%. Upon HAGLR inhibition, fibrosis proteins were downregulated. HAGLR has utility in the auxiliary diagnosis of IPF, as it can differentiate IPF from other conditions. HAGLR inhibition could alleviate fibrosis at the cellular level.
ArticleNumber	149717
Author	Han, Siqi Liu, Ruoyu Cao, Yongtong Hu, Lijuan Zhou, Yun Zhang, Ruyue
Author_xml	– sequence: 1 givenname: Lijuan surname: Hu fullname: Hu, Lijuan organization: Department of Clinical Laboratory, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, China – sequence: 2 givenname: Ruoyu surname: Liu fullname: Liu, Ruoyu organization: Department of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, PR China – sequence: 3 givenname: Siqi surname: Han fullname: Han, Siqi organization: Department of Clinical Laboratory, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, China – sequence: 4 givenname: Ruyue surname: Zhang fullname: Zhang, Ruyue organization: Department of Clinical Laboratory, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Beijing, China – sequence: 5 givenname: Yun surname: Zhou fullname: Zhou, Yun email: zryhyyzy@126.com organization: Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100101, China – sequence: 6 givenname: Yongtong orcidid: 0000-0002-2019-7088 surname: Cao fullname: Cao, Yongtong email: caoyongtong100@sina.com organization: Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100101, China
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Keywords	ILD Biomarker Idiopathic pulmonary fibrosis LncRNA CDNA TNF AUC IFN-α IFN-γ ANOVA CA15-3 CA125 WBC HRCT GSE231693 CEA HAGLR NSE HGB IL HFL-1 CI ROC qRT-PCR TBST KL-6 Pro-GRP Cyfra21-1 GEO COL1A1 IIP SCC COL3A1 ShRNA NC TGF-β1 Non-coding RNA UIP GAPDH IPF
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Snippet	•This is the first study to investigate the role of lncRNA HAGLR in IPF.•HAGLR can distinguish IPF from other pulmonary diseases.•HAGLR can influence the... Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, has a severe prognosis, and its diagnosis is difficult. Long non-coding RNAs...
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SubjectTerms	Aged Biomarker Biomarkers - blood Biomarkers - metabolism Case-Control Studies Female Humans Idiopathic pulmonary fibrosis Idiopathic Pulmonary Fibrosis - blood Idiopathic Pulmonary Fibrosis - diagnosis Idiopathic Pulmonary Fibrosis - genetics Male Middle Aged Non-coding RNA RNA, Long Noncoding - blood RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism ROC Curve
Title	Long non-coding RNA HAGLR: The potential biomarker plays an important role in idiopathic pulmonary fibrosis
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