Optimal use of intravenous landiolol in acute cardiac care

B-blockers are regarded as beneficial pharmacologic agents in cardiac care, but their role in the acute setting remains ambiguous. Increasing evidence supports the important role of landiolol in critical care, a highly cardioselective intravenous b-blocker with rapid onset of action and short elimin...

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Vydáno v:Expert review of cardiovascular therapy Ročník 21; číslo 11; s. 855 - 866
Hlavní autoři: Bezati, Sofia, Boultadakis, Antonios, Ventoulis, Ioannis, Polyzogopoulou, Eftihia, Parissis, John T.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 02.11.2023
Témata:
ventricular tachycardia/fibrillation
atrial fibrillation
percutaneous coronary intervention
β1-blocker1
septic cardiomyopathy
landiolol
Acute heart failure
pharmacology
ISSN:1477-9072, 1744-8344, 1744-8344
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Shrnutí:B-blockers are regarded as beneficial pharmacologic agents in cardiac care, but their role in the acute setting remains ambiguous. Increasing evidence supports the important role of landiolol in critical care, a highly cardioselective intravenous b-blocker with rapid onset of action and short elimination time. Among its most valuable properties, which may aid to overcome special reservations related to b-blocker therapy in the acute setting, landiolol has a potent negative chronotropic effect while at the same time it exhibits a mild negative inotropic effect. This expert opinion review aims to present basic pharmacologic aspects of landiolol and provide current clinical research focused on its efficacy and safety. Landiolol is a valuable and safe pharmacologic agent in acute cardiac care. Japanese and European guidelines have incorporated its use for the management of atrial tachyarrhythmia in patients with cardiac dysfunction. Although emerging clinical trials have experimented its use in patients with sustained ventricular tachycardia/fibrillation, acute myocardial infarction undergoing primary percutaneous intervention and in patients with septic cardiomyopathy, more studies are needed in order to establish its value in such cardiac conditions.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1477-9072
1744-8344
1744-8344
DOI:10.1080/14779072.2023.2277354