Understanding mechanotransduction in the distal colon and rectum via multiscale and multimodal computational modeling

Visceral pain in the large bowel is a defining symptom of irritable bowel syndrome (IBS) and the primary reason that patients visit gastroenterologists. This pain is reliably triggered by mechanical distension of the distal colon and rectum (colorectum). Consequently, the process of mechanotransduct...

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Bibliographic Details
Published in:	Journal of the mechanical behavior of biomedical materials Vol. 160; p. 106771
Main Authors:	Shokrani, Amirhossein, Almasi, Ashkan, Feng, Bin, Pierce, David M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.12.2024
Subjects:	Action potentials Animals Biomechanical Phenomena Colon - physiology Computer Simulation Finite Element Analysis Finite element modeling Irritable bowel syndrome Mechanical Phenomena Mechanosensitive ion channels Mechanotransduction Mechanotransduction, Cellular Mice Multiscale computational modeling Rectum Stress, Mechanical Action potentials Mechanotransduction Multiscale computational modeling Finite element modeling Mechanosensitive ion channels Irritable bowel syndrome
ISSN:	1751-6161, 1878-0180, 1878-0180
Online Access:	Get full text
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