Effects of intramuscular administration of Platelet-Rich Plasma on denervated muscle after peripheral nerve injury

After peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this work is to analyze the effect of intramuscular Platelet-Rich Plasma (PRP) in a denervated muscle due to PNI.Materials and. An irreversible PN...

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Vydané v:	Connective tissue research Ročník 66; číslo 1; s. 10 - 25
Hlavní autori:	Soldado, Francisco, López de Jesús, Maider, Beitia, Maider, González-Burguera, Imanol, Ocerin, Garazi, Elejaga-Jimeno, Ainhoa, Saumell-Esnaola, Miquel, Barrondo, Sergio, Oraa, Jaime, Sallés, Joan, Delgado, Diego, García Del Caño, Gontzal, Sánchez, Mikel
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 02.01.2025
Predmet:	Animals Injections, Intramuscular Male Muscle Denervation Muscle, Skeletal - innervation Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Myogenin - metabolism Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - pathology Peripheral Nerve Injuries - therapy Platelet-Rich Plasma - metabolism Rats Rats, Wistar Receptors, Nicotinic - metabolism Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - pathology Denervated muscle peripheral nerve injury muscle satellite cells platelet-richplasma neuromuscular junction
ISSN:	0300-8207, 1607-8438, 1607-8438
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Abstract	After peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this work is to analyze the effect of intramuscular Platelet-Rich Plasma (PRP) in a denervated muscle due to PNI.Materials and. An irreversible PNI was generated in the common peroneal nerve of 80 Wistar rats by nerve resection. Animals were divided into groups: non-treatment (NT), saline (S) and PRP (PRP). 200 uL of saline (S group) and PRP (PRP group) were infiltrated intramuscularly into the tibialis anterior muscle on a weekly basis, from surgery to sacrifice (at 2, 4 and 7 weeks). Muscles were histologically processed for immunofluorescence and Western blotting. Effects on nicotinic acetylcholine receptor (nAChR), satellite cells (SC) and myogenin expression were analyzed. Comparisons were performed by two-way analysis of variance (ANOVA). PRP had a platelet concentration 1.5-fold higher than blood, without erythrocytes and leukocytes. The PRP group had a higher percentage weight than the S and NT groups ( < 0.05). The levels of nAChRα1 and nAChRε subunit were lower in the PRP group relative to the NT and S ( < 0.05), while the nAChRγ subunit showed an increase in the PRP group ( < 0.05). The activation of SCs was higher in the PRP group compared to NT and S groups ( < 0.05). PRP treatment can modulate NMJ configuration as well as key myogenic regulatory factors in denervated muscle, enhancing SC activation while mitigating muscle atrophy.
AbstractList	After peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this work is to analyze the effect of intramuscular Platelet-Rich Plasma (PRP) in a denervated muscle due to PNI.Materials and. An irreversible PNI was generated in the common peroneal nerve of 80 Wistar rats by nerve resection. Animals were divided into groups: non-treatment (NT), saline (S) and PRP (PRP). 200 uL of saline (S group) and PRP (PRP group) were infiltrated intramuscularly into the tibialis anterior muscle on a weekly basis, from surgery to sacrifice (at 2, 4 and 7 weeks). Muscles were histologically processed for immunofluorescence and Western blotting. Effects on nicotinic acetylcholine receptor (nAChR), satellite cells (SC) and myogenin expression were analyzed. Comparisons were performed by two-way analysis of variance (ANOVA). PRP had a platelet concentration 1.5-fold higher than blood, without erythrocytes and leukocytes. The PRP group had a higher percentage weight than the S and NT groups ( < 0.05). The levels of nAChRα1 and nAChRε subunit were lower in the PRP group relative to the NT and S ( < 0.05), while the nAChRγ subunit showed an increase in the PRP group ( < 0.05). The activation of SCs was higher in the PRP group compared to NT and S groups ( < 0.05). PRP treatment can modulate NMJ configuration as well as key myogenic regulatory factors in denervated muscle, enhancing SC activation while mitigating muscle atrophy. After peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this work is to analyze the effect of intramuscular Platelet-Rich Plasma (PRP) in a denervated muscle due to PNI.Materials and.PURPOSEAfter peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this work is to analyze the effect of intramuscular Platelet-Rich Plasma (PRP) in a denervated muscle due to PNI.Materials and.An irreversible PNI was generated in the common peroneal nerve of 80 Wistar rats by nerve resection. Animals were divided into groups: non-treatment (NT), saline (S) and PRP (PRP). 200 uL of saline (S group) and PRP (PRP group) were infiltrated intramuscularly into the tibialis anterior muscle on a weekly basis, from surgery to sacrifice (at 2, 4 and 7 weeks). Muscles were histologically processed for immunofluorescence and Western blotting. Effects on nicotinic acetylcholine receptor (nAChR), satellite cells (SC) and myogenin expression were analyzed. Comparisons were performed by two-way analysis of variance (ANOVA).METHODSAn irreversible PNI was generated in the common peroneal nerve of 80 Wistar rats by nerve resection. Animals were divided into groups: non-treatment (NT), saline (S) and PRP (PRP). 200 uL of saline (S group) and PRP (PRP group) were infiltrated intramuscularly into the tibialis anterior muscle on a weekly basis, from surgery to sacrifice (at 2, 4 and 7 weeks). Muscles were histologically processed for immunofluorescence and Western blotting. Effects on nicotinic acetylcholine receptor (nAChR), satellite cells (SC) and myogenin expression were analyzed. Comparisons were performed by two-way analysis of variance (ANOVA).PRP had a platelet concentration 1.5-fold higher than blood, without erythrocytes and leukocytes. The PRP group had a higher percentage weight than the S and NT groups (p < 0.05). The levels of nAChRα1 and nAChRε subunit were lower in the PRP group relative to the NT and S (p < 0.05), while the nAChRγ subunit showed an increase in the PRP group (p < 0.05). The activation of SCs was higher in the PRP group compared to NT and S groups (p < 0.05).RESULTSPRP had a platelet concentration 1.5-fold higher than blood, without erythrocytes and leukocytes. The PRP group had a higher percentage weight than the S and NT groups (p < 0.05). The levels of nAChRα1 and nAChRε subunit were lower in the PRP group relative to the NT and S (p < 0.05), while the nAChRγ subunit showed an increase in the PRP group (p < 0.05). The activation of SCs was higher in the PRP group compared to NT and S groups (p < 0.05).PRP treatment can modulate NMJ configuration as well as key myogenic regulatory factors in denervated muscle, enhancing SC activation while mitigating muscle atrophy.CONCLUSIONPRP treatment can modulate NMJ configuration as well as key myogenic regulatory factors in denervated muscle, enhancing SC activation while mitigating muscle atrophy.
Author	García Del Caño, Gontzal Saumell-Esnaola, Miquel Beitia, Maider López de Jesús, Maider Oraa, Jaime Sallés, Joan Barrondo, Sergio Sánchez, Mikel Ocerin, Garazi Soldado, Francisco González-Burguera, Imanol Delgado, Diego Elejaga-Jimeno, Ainhoa
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Snippet	After peripheral nerve injury (PNI), prolonged denervation of the target muscle prevents adequate reinnervation even if the nerve is repaired. The aim of this...
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SubjectTerms	Animals Injections, Intramuscular Male Muscle Denervation Muscle, Skeletal - innervation Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Myogenin - metabolism Peripheral Nerve Injuries - metabolism Peripheral Nerve Injuries - pathology Peripheral Nerve Injuries - therapy Platelet-Rich Plasma - metabolism Rats Rats, Wistar Receptors, Nicotinic - metabolism Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - pathology
Title	Effects of intramuscular administration of Platelet-Rich Plasma on denervated muscle after peripheral nerve injury
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