Characterization of Mg-independent and Mg-dependent Ecto-ATPase activities in luminal a breast cancer MCF-7 cells

Breast cancer remains the most prevalent malignancy among women, characterized by molecular heterogeneity and complex tumor microenvironment interactions. Purinergic signaling, particularly through extracellular adenosine triphosphate (ATP) hydrolysis, plays a significant role in regulating cancer p...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 777; p. 152256
Main Authors:	Lacerda-Abreu, Marco Antonio, Silva, Enderson, Mendonça, Bruna dos Santos, de Moraes, Gabriela Nestal, Meyer-Fernandes, José Roberto
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2025
Subjects:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Adhesion Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell migration Ecto-ATPase Extracellular ATP hydrolysis Female Humans Hydrolysis Kinetics Magnesium - metabolism MCF-7 Cells MCF-7 cells Mg2+-dependent ATPase activity Purinergic signaling Substrate Specificity Tumor microenvironment PR APCP ALP MCF-7 MCF10-A NTP ADP FBS Pi cDNA Mg2+-dependent ATPase activity NDP RT-qPCR PBS ENTPDase Tumor microenvironment AMP MCF-7 cells EGF Breast cancer Adhesion ER ECM Extracellular ATP hydrolysis NMP Ecto-ATPase DIDS ARL67156 HER2 ATP Cell migration PCR Purinergic signaling Mg(2+)-dependent ATPase activity
ISSN:	0006-291X, 1090-2104, 1090-2104
Online Access:	Get full text
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