Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade

The transforming growth factor beta (TGFbeta) pathway orchestrates an extensive transcriptional program that is important for many processes in the cell. For example, TGFbeta regulates cell cycle, migration, and epithelial-to-mesenchymal transition. The TGFbeta pathway has a dual role in cancer: it...

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Vydáno v:	Molecular cancer research Ročník 8; číslo 4; s. 592
Hlavní autoři:	Mullenders, Jasper, Fabius, Armida W M, van Dongen, Miranda M W, Kuiken, Hendrik J, Beijersbergen, Roderick L, Bernards, René
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.04.2010
Témata:	Active Transport, Cell Nucleus - genetics Cell Line, Tumor Down-Regulation - genetics Gene Expression Regulation, Neoplastic - genetics Genes, cdc - physiology Genetic Testing Humans Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Neoplasm Invasiveness - genetics RNA, Small Interfering - genetics Signal Transduction - genetics Smad2 Protein - genetics Smad2 Protein - metabolism Transforming Growth Factor beta - genetics
ISSN:	1557-3125, 1557-3125
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