Caspase-1 deficient mice are more susceptible to influenza A virus infection with PA variation

Reassortment within polymerase genes causes changes in the pathogenicity of influenza A viruses. We previously reported that the 2009 pH1N1 PA enhanced the pathogenicity of seasonal H1N1. We examined the effects of the PA gene from the HPAI H5N1 following its introduction into currently circulating...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 208; no. 11; p. 1898
Main Authors:	Huang, Chih-Heng, Chen, Chi-Jene, Yen, Chia-Tsui, Yu, Cheng-Ping, Huang, Peng-Nien, Kuo, Rei-Lin, Lin, Sue-Jane, Chang, Cheng-Kai, Shih, Shin-Ru
Format:	Journal Article
Language:	English
Published:	United States 01.12.2013
Subjects:	Animals Caspase 1 - metabolism Cell Line Disease Models, Animal Dogs Genetic Engineering Humans Immunity, Innate Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - immunology Influenza A Virus, H3N2 Subtype - pathogenicity Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - pathogenicity Influenza, Human - immunology Influenza, Human - virology Lung - pathology Lung - virology Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Reassortant Viruses RNA Replicase - genetics RNA Replicase - metabolism Specific Pathogen-Free Organisms Viral Proteins - genetics Viral Proteins - metabolism Virulence Virus Replication pathogenesis caspase-1 acidic polymerase influenza reassortant
ISSN:	1537-6613, 1537-6613
Online Access:	Get more information
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