Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability

Unstable atherosclerotic lesions in carotid arteries require surgical endarterectomy to reduce the risk of ischemic stroke. We aimed to identify microRNAs that exert a broad effect on atherosclerotic plaque formation and stability in the carotid artery. We made a selection of 164 genes involved in a...

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Bibliographic Details
Published in:	Annals of surgery Vol. 262; no. 5; pp. 841 - 7; discussion 847-8
Main Authors:	Wezel, Anouk, Welten, Sabine M J, Razawy, Wida, Lagraauw, H Maxime, de Vries, Margreet R, Goossens, Eveline A C, Boonstra, Martin C, Hamming, Jaap F, Kandimalla, Ekambar R, Kuiper, Johan, Quax, Paul H A, Nossent, A Yaël, Bot, Ilze
Format:	Journal Article
Language:	English
Published:	United States 01.11.2015
Subjects:	Animals Atherosclerosis - genetics Atherosclerosis - metabolism Blotting, Western Carotid Arteries Disease Models, Animal DNA - genetics Gene Expression Regulation Humans Male Mice MicroRNAs - biosynthesis MicroRNAs - genetics Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Reverse Transcriptase Polymerase Chain Reaction
ISSN:	1528-1140
Online Access:	Get more information
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