More fraudulent history of cancer risk assessment: The US National Academy of Sciences Biological Effects of Atomic Radiation (BEAR) I Genetics Panel used falsified data greatly exaggerating hereditary/cancer risks

This paper reports that data used by the US National Academy of Sciences (NAS) Biological Effects of Atomic Radiation (BEAR) I Genetics Panel (1956) to estimate risks of hereditary damage in the US population were falsified, greatly exaggerating the risks. These risk estimates were mostly based on t...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Chemico-biological interactions Ročník 419; s. 111640
Hlavní autoři: Calabrese, Edward J., Selby, Paul B.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Ireland Elsevier B.V 08.10.2025
Témata:
Animals
Dose response
History, 20th Century
Humans
Ionizing radiation
Linear non-threshold
Mice
Mutation
National Academy of Sciences, U.S. - history
Neoplasms - etiology
Neoplasms - genetics
Neoplasms, Radiation-Induced - genetics
Risk Assessment
Scientific Misconduct
United States
United States
Linear non-threshold
Scientific misconduct
Ionizing radiation
Mutation
Dose response
Risk assessment
ISSN:0009-2797, 1872-7786, 1872-7786
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:This paper reports that data used by the US National Academy of Sciences (NAS) Biological Effects of Atomic Radiation (BEAR) I Genetics Panel (1956) to estimate risks of hereditary damage in the US population were falsified, greatly exaggerating the risks. These risk estimates were mostly based on the first of many mouse specific-locus experiments of William and Liane Russell, Oak Ridge National Laboratory, which were determined in 1996 to be erroneous by a US Department of Energy (DOE) investigation of scientific misconduct. The basis of the falsification is that William Russell removed data on a large mutation cluster from the control group resulting in a falsely elevated estimate of the induced frequency of radiation-induced gene mutations. While DOE subsequently compelled the Russells to correct the record, these corrections were never retrospectively applied to the Genetics Panel (1956) report, which used the falsified Russell data. Thus, no corrections have been made by the NAS or regulatory agencies, such as the EPA, whose national risk assessment policies/practices for cancer risk assessment were significantly corrupted and overstated by these errors. Based on the discovery reported herein that the Genetics Panel's policy recommendations considerably overestimated hereditary risks based upon Russell-inspired falsified publication, it seems imperative that the Genetics Panel report (1956) published in Science be retracted due to inherent falsification-based inaccuracies that continue to impact governmental regulatory agencies, such as the EPA, and the global community that often rely upon the US NAS and regulatory agencies for guidance, as well as the broader scientific community and general public. •The recommendation to adopt LNT by the US NAS was based on falsified data.•Correction of the falsified record supported a threshold model.•The Science journal paper of the NAS falsified report should be retracted.•A correction based on the corrected conclusions should be published.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0009-2797
1872-7786
1872-7786
DOI:10.1016/j.cbi.2025.111640