Proteoform identification based on top-down tandem mass spectra with peak error corrections

Abstract In this paper, we study the problem for finding complex proteoforms from protein databases based on top-down tandem mass spectrum data. The main difficulty to solve the problem is to handle the combinatorial explosion of various alterations on a protein. To overcome the combinatorial explos...

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Bibliographic Details
Published in:	Briefings in bioinformatics Vol. 23; no. 2
Main Authors:	Zhan, Zhaohui, Wang, Lusheng
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 10.03.2022 Oxford Publishing Limited (England)
Subjects:	Algorithms Alignment Combinatorial analysis Computer programs Databases, Protein Error correction Mass spectra Nodes Proteins Software Software packages Tandem Mass Spectrometry - methods proteoform identification peak error correction dynamic programming algorithms top-down tandem mass spectra
ISSN:	1467-5463, 1477-4054, 1477-4054
Online Access:	Get full text
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