A novel salt-free ruthenium-catalyzed alkylation of aryl amines

For the first time the alkylation of aryl amines using cyclic amines, for example, pyrrolidine is described. This novel reaction proceeds without the need of external hydrogen or pressure under ambient conditions in the presence of the Shvo catalyst. The alkylation of aryl amines using cyclic amines...

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Vydáno v:Tetrahedron letters Ročník 49; číslo 40; s. 5742 - 5745
Hlavní autoři: Hollmann, Dirk, Bähn, Sebastian, Tillack, Annegret, Parton, Rudy, Altink, Rinke, Beller, Matthias
Médium: Journal Article
Jazyk:angličtina
Vydáno: Elsevier Ltd 29.09.2008
Témata:
Amination
Amines
N-Alkylation
Ruthenium
Shvo catalyst
Shvo catalyst
N-Alkylation
Amines
Ruthenium
Amination
ISSN:0040-4039, 1873-3581
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Shrnutí:For the first time the alkylation of aryl amines using cyclic amines, for example, pyrrolidine is described. This novel reaction proceeds without the need of external hydrogen or pressure under ambient conditions in the presence of the Shvo catalyst. The alkylation of aryl amines using cyclic amines such as pyrrolidine proceeds via borrowing hydrogen methodology in the presence of 1 mol % Shvo catalyst. During the reaction multiple carbon–nitrogen cleavage and formation occurred. This novel reaction sequence leads to N-aryl-pyrrolidines and -piperidines.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2008.07.107