Engineered iron-oxide-based nanoparticles as enhanced T1 contrast agents for efficient tumor imaging

We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (GdIO) nanoparticles, which exhibit a strong T1 contrast effect for tumor imaging through enhanced permeation and retention effect and the ability to clear out of the body in living subjects. The combi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:ACS nano Ročník 7; číslo 4; s. 3287 - 3296
Hlavní autoři: Zhou, Zijian, Wang, Lirong, Chi, Xiaoqin, Bao, Jianfeng, Yang, Lijiao, Zhao, Wenxiu, Chen, Zhong, Wang, Xiaomin, Chen, Xiaoyuan, Gao, Jinhao
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 23.04.2013
Témata:
Animals
Cell Line, Tumor
Contrast Media - chemical synthesis
Female
Gadolinium - chemistry
Humans
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles - chemistry
Mice
Nanocapsules - chemistry
Ovarian Neoplasms - pathology
Reproducibility of Results
Sensitivity and Specificity
ISSN:1936-0851, 1936-086X, 1936-086X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (GdIO) nanoparticles, which exhibit a strong T1 contrast effect for tumor imaging through enhanced permeation and retention effect and the ability to clear out of the body in living subjects. The combination of spin-canting effects and the collection of gadolinium species within small-sized GdIO nanoparticles led to a significantly enhanced T1 contrast effect. For example, GdIO nanoparticles with a diameter of ∼4.8 nm exhibited a high r1 relaxivity of 7.85 mM(-1)·S(-1) and a low r2/r1 ratio of 5.24. After being coated with zwitterionic dopamine sulfonate molecules, the 4.8 nm GdIO nanoparticles showed a steady hydrodynamic diameter (∼5.2 nm) in both PBS buffer and fetal bovine serum solution, indicating a low nonspecific protein absorption. This study provides a valuable strategy for the design of highly sensitive iron-oxide-based T1 contrast agents with relatively long circulation half-lives (∼50 min), efficient tumor passive targeting (SKOV3, human ovarian cancer xenograft tumor as a model), and the possibility of rapid renal clearance after tumor imaging.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1936-0851
1936-086X
1936-086X
DOI:10.1021/nn305991e