Engineered iron-oxide-based nanoparticles as enhanced T1 contrast agents for efficient tumor imaging

We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (GdIO) nanoparticles, which exhibit a strong T1 contrast effect for tumor imaging through enhanced permeation and retention effect and the ability to clear out of the body in living subjects. The combi...

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Bibliographic Details
Published in:ACS nano Vol. 7; no. 4; pp. 3287 - 3296
Main Authors: Zhou, Zijian, Wang, Lirong, Chi, Xiaoqin, Bao, Jianfeng, Yang, Lijiao, Zhao, Wenxiu, Chen, Zhong, Wang, Xiaomin, Chen, Xiaoyuan, Gao, Jinhao
Format: Journal Article
Language:English
Published: United States 23.04.2013
Subjects:
Animals
Cell Line, Tumor
Contrast Media - chemical synthesis
Female
Gadolinium - chemistry
Humans
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles - chemistry
Mice
Nanocapsules - chemistry
Ovarian Neoplasms - pathology
Reproducibility of Results
Sensitivity and Specificity
ISSN:1936-0851, 1936-086X, 1936-086X
Online Access:Get full text
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Summary:We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (GdIO) nanoparticles, which exhibit a strong T1 contrast effect for tumor imaging through enhanced permeation and retention effect and the ability to clear out of the body in living subjects. The combination of spin-canting effects and the collection of gadolinium species within small-sized GdIO nanoparticles led to a significantly enhanced T1 contrast effect. For example, GdIO nanoparticles with a diameter of ∼4.8 nm exhibited a high r1 relaxivity of 7.85 mM(-1)·S(-1) and a low r2/r1 ratio of 5.24. After being coated with zwitterionic dopamine sulfonate molecules, the 4.8 nm GdIO nanoparticles showed a steady hydrodynamic diameter (∼5.2 nm) in both PBS buffer and fetal bovine serum solution, indicating a low nonspecific protein absorption. This study provides a valuable strategy for the design of highly sensitive iron-oxide-based T1 contrast agents with relatively long circulation half-lives (∼50 min), efficient tumor passive targeting (SKOV3, human ovarian cancer xenograft tumor as a model), and the possibility of rapid renal clearance after tumor imaging.
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ISSN:1936-0851
1936-086X
1936-086X
DOI:10.1021/nn305991e