CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses

Whereas CD4 T cells conventionally mediate antitumor immunity by providing help to CD8 T cells, recent clinical studies have implied an important role for cytotoxic CD4 T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4 T cell responses a...

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Bibliographic Details

Published in:	Science immunology Vol. 9; no. 91; p. eadi9517
Main Authors:	Bawden, Emma G, Wagner, Teagan, Schröder, Jan, Effern, Maike, Hinze, Daniel, Newland, Lewis, Attrill, Grace H, Lee, Ariane R, Engel, Sven, Freestone, David, de Lima Moreira, Marcela, Gressier, Elise, McBain, Nathan, Bachem, Annabell, Haque, Ashraful, Dong, Ruining, Ferguson, Angela L, Edwards, Jarem J, Ferguson, Peter M, Scolyer, Richard A, Wilmott, James S, Jewell, Christopher M, Brooks, Andrew G, Gyorki, David E, Palendira, Umaimainthan, Bedoui, Sammy, Waithman, Jason, Hochheiser, Katharina, Hölzel, Michael, Gebhardt, Thomas
Format:	Journal Article
Language:	English
Published:	United States 19.01.2024
Subjects:	CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Histocompatibility Antigens Class II HLA Antigens Humans Melanoma Skin Neoplasms
ISSN:	2470-9468, 2470-9468
Online Access:	Get more information
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