CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses

Whereas CD4 T cells conventionally mediate antitumor immunity by providing help to CD8 T cells, recent clinical studies have implied an important role for cytotoxic CD4 T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4 T cell responses a...

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Veröffentlicht in:	Science immunology Jg. 9; H. 91; S. eadi9517
Hauptverfasser:	Bawden, Emma G, Wagner, Teagan, Schröder, Jan, Effern, Maike, Hinze, Daniel, Newland, Lewis, Attrill, Grace H, Lee, Ariane R, Engel, Sven, Freestone, David, de Lima Moreira, Marcela, Gressier, Elise, McBain, Nathan, Bachem, Annabell, Haque, Ashraful, Dong, Ruining, Ferguson, Angela L, Edwards, Jarem J, Ferguson, Peter M, Scolyer, Richard A, Wilmott, James S, Jewell, Christopher M, Brooks, Andrew G, Gyorki, David E, Palendira, Umaimainthan, Bedoui, Sammy, Waithman, Jason, Hochheiser, Katharina, Hölzel, Michael, Gebhardt, Thomas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.01.2024
Schlagworte:	CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Histocompatibility Antigens Class II HLA Antigens Humans Melanoma Skin Neoplasms
ISSN:	2470-9468, 2470-9468
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