Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis

Weight gain, leading to further morbidity and poor treatment adherence, is a common consequence of treatment with antipsychotic drugs. Two recent studies in the same cohort of Chinese Han subjects have shown that polymorphisms of the promoter regions of both the serotonin 5-hydroxytryptamine 2C (5-H...

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Vydané v:	Pharmacogenetics and genomics Ročník 15; číslo 4; s. 195
Hlavní autori:	Templeman, Lucy A, Reynolds, Gavin P, Arranz, Belen, San, Luis
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.04.2005
Predmet:	Adult Affective Disorders, Psychotic - complications Affective Disorders, Psychotic - drug therapy Alleles Antipsychotic Agents - adverse effects Antipsychotic Agents - pharmacology Benzodiazepines - pharmacology Body Mass Index Female Genetic Variation Genotype Humans Leptin - blood Leptin - genetics Male Models, Genetic Olanzapine Pharmacogenetics Polymorphism, Genetic Promoter Regions, Genetic Receptor, Serotonin, 5-HT2C - genetics Receptors, Leptin Schizophrenia - drug therapy Time Factors Weight Gain - drug effects Weight Gain - genetics
ISSN:	1744-6872
On-line prístup:	Zistit podrobnosti o prístupe
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