AFM imaging of the transcriptionally active chromatin in mammalian cells' nuclei

Nuclear rigidity is traditionally associated with lamina and densely packed heterochromatin. Actively transcribed DNA is thought to be less densely packed. Currently, approaches for direct measurements of the transcriptionally active chromatin rigidity are quite limited. Isolated nuclei were subject...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1866; no. 12; p. 130234
Main Authors:	Bairamukov, V.Yu, Filatov, M.V., Kovalev, R.A., Fedorova, N.D., Pantina, R.A., Ankudinov, A.V., Iashina, E.G., Grigoriev, S.V., Varfolomeeva, E.Yu
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01.12.2022
Subjects:	Actinomycin D AFM atomic force microscopy Cell nucleus Chromatin deformation fibroblasts heterochromatin landscapes mammals Mechanical deformation supercoiled DNA Transcription transcription (genetics) Actinomycin D AFM Chromatin Transcription Cell nucleus Mechanical deformation
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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