Liver Stiffness Measurements with MR Elastography: Agreement and Repeatability across Imaging Systems, Field Strengths, and Pulse Sequences
Purpose To prospectively assess agreement and repeatability of magnetic resonance (MR) elastography liver stiffness measurements across imager manufacturers, field strengths, and pulse sequences. Materials and Methods This prospective cross-sectional study was approved by the institutional review bo...
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| Veröffentlicht in: | Radiology Jg. 281; H. 3; S. 793 - 804 |
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| Abstract | Purpose To prospectively assess agreement and repeatability of magnetic resonance (MR) elastography liver stiffness measurements across imager manufacturers, field strengths, and pulse sequences. Materials and Methods This prospective cross-sectional study was approved by the institutional review board; informed consent was obtained from all subjects. On the basis of an a priori power calculation, 24 volunteer adult subjects underwent MR elastography with four MR imaging systems (two vendors) and multiple pulse sequences (two-dimensional [2D] gradient-echo [GRE] imaging, 2D spin-echo [SE] echo-planar imaging, and three-dimensional [3D] SE echo-planar imaging). Each sequence was performed twice in each patient with each imaging system. Intraclass correlation coefficients (ICCs) were used to assess agreement and repeatability. P < .05 was considered indicative of a statistically significant difference. Results Pairwise ICCs were 0.67-0.82 and 0.62-0.83 for agreement between pulse sequences across manufacturers (n = 4) and field strengths (n = 5), respectively. ICCs were 0.45-0.90 for pairwise agreement between sequences while fixing manufacturer and field strength (n = 8). Test-retest repeatability across the various manufacturer, field strength, and pulse sequence combinations (n = 10) was excellent (ICCs, 0.77-0.94). The overall ICC for all manufacturer, field strength, and sequence combinations (n = 10) was 0.68 (95% confidence interval [CI]: 0.55, 0.82). ICC according to field strength was 0.78 (95% CI: 0.67, 0.88) at 1.5 T (n = 5) and 0.64 (95% CI: 0.49, 0.78) at 3.0 T (n = 5). ICCs according to vendor were 0.83 (95% CI: 0.73, 0.91) (n = 4) and 0.65 (95% CI: 0.51, 0.79) (n = 6). Average patient level variance was 0.042 kPa, with a coefficient of variation of 10.7%. Conclusion MR elastography is a reliable method for assessing liver stiffness, with small amounts of variability between imager manufacturers, field strengths, and pulse sequences.
RSNA, 2016. |
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| AbstractList | Purpose To prospectively assess agreement and repeatability of magnetic resonance (MR) elastography liver stiffness measurements across imager manufacturers, field strengths, and pulse sequences. Materials and Methods This prospective cross-sectional study was approved by the institutional review board; informed consent was obtained from all subjects. On the basis of an a priori power calculation, 24 volunteer adult subjects underwent MR elastography with four MR imaging systems (two vendors) and multiple pulse sequences (two-dimensional [2D] gradient-echo [GRE] imaging, 2D spin-echo [SE] echo-planar imaging, and three-dimensional [3D] SE echo-planar imaging). Each sequence was performed twice in each patient with each imaging system. Intraclass correlation coefficients (ICCs) were used to assess agreement and repeatability. P < .05 was considered indicative of a statistically significant difference. Results Pairwise ICCs were 0.67-0.82 and 0.62-0.83 for agreement between pulse sequences across manufacturers (n = 4) and field strengths (n = 5), respectively. ICCs were 0.45-0.90 for pairwise agreement between sequences while fixing manufacturer and field strength (n = 8). Test-retest repeatability across the various manufacturer, field strength, and pulse sequence combinations (n = 10) was excellent (ICCs, 0.77-0.94). The overall ICC for all manufacturer, field strength, and sequence combinations (n = 10) was 0.68 (95% confidence interval [CI]: 0.55, 0.82). ICC according to field strength was 0.78 (95% CI: 0.67, 0.88) at 1.5 T (n = 5) and 0.64 (95% CI: 0.49, 0.78) at 3.0 T (n = 5). ICCs according to vendor were 0.83 (95% CI: 0.73, 0.91) (n = 4) and 0.65 (95% CI: 0.51, 0.79) (n = 6). Average patient level variance was 0.042 kPa, with a coefficient of variation of 10.7%. Conclusion MR elastography is a reliable method for assessing liver stiffness, with small amounts of variability between imager manufacturers, field strengths, and pulse sequences. © RSNA, 2016. Purpose To prospectively assess agreement and repeatability of magnetic resonance (MR) elastography liver stiffness measurements across imager manufacturers, field strengths, and pulse sequences. Materials and Methods This prospective cross-sectional study was approved by the institutional review board; informed consent was obtained from all subjects. On the basis of an a priori power calculation, 24 volunteer adult subjects underwent MR elastography with four MR imaging systems (two vendors) and multiple pulse sequences (two-dimensional [2D] gradient-echo [GRE] imaging, 2D spin-echo [SE] echo-planar imaging, and three-dimensional [3D] SE echo-planar imaging). Each sequence was performed twice in each patient with each imaging system. Intraclass correlation coefficients (ICCs) were used to assess agreement and repeatability. P < .05 was considered indicative of a statistically significant difference. Results Pairwise ICCs were 0.67-0.82 and 0.62-0.83 for agreement between pulse sequences across manufacturers (n = 4) and field strengths (n = 5), respectively. ICCs were 0.45-0.90 for pairwise agreement between sequences while fixing manufacturer and field strength (n = 8). Test-retest repeatability across the various manufacturer, field strength, and pulse sequence combinations (n = 10) was excellent (ICCs, 0.77-0.94). The overall ICC for all manufacturer, field strength, and sequence combinations (n = 10) was 0.68 (95% confidence interval [CI]: 0.55, 0.82). ICC according to field strength was 0.78 (95% CI: 0.67, 0.88) at 1.5 T (n = 5) and 0.64 (95% CI: 0.49, 0.78) at 3.0 T (n = 5). ICCs according to vendor were 0.83 (95% CI: 0.73, 0.91) (n = 4) and 0.65 (95% CI: 0.51, 0.79) (n = 6). Average patient level variance was 0.042 kPa, with a coefficient of variation of 10.7%. Conclusion MR elastography is a reliable method for assessing liver stiffness, with small amounts of variability between imager manufacturers, field strengths, and pulse sequences. RSNA, 2016. |
| Author | Trout, Andrew T Mahley, Alana D Zhang, Yue Wang, Hui Zhang, Bin Serai, Suraj Dillman, Jonathan R |
| Author_xml | – sequence: 1 givenname: Andrew T orcidid: 0000-0003-1431-4054 surname: Trout fullname: Trout, Andrew T organization: From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.) – sequence: 2 givenname: Suraj orcidid: 0000-0002-8821-0971 surname: Serai fullname: Serai, Suraj organization: From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.) – sequence: 3 givenname: Alana D surname: Mahley fullname: Mahley, Alana D organization: From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.) – sequence: 4 givenname: Hui surname: Wang fullname: Wang, Hui organization: From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.) – sequence: 5 givenname: Yue surname: Zhang fullname: Zhang, Yue organization: From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.) – sequence: 6 givenname: Bin surname: Zhang fullname: Zhang, Bin organization: From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.) – sequence: 7 givenname: Jonathan R surname: Dillman fullname: Dillman, Jonathan R organization: From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.) |
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| SubjectTerms | Adipose Tissue - diagnostic imaging Adipose Tissue - physiopathology Adult Cross-Sectional Studies Elasticity Imaging Techniques - instrumentation Elasticity Imaging Techniques - methods Elasticity Imaging Techniques - standards Fatty Liver - diagnostic imaging Fatty Liver - physiopathology Female Healthy Volunteers Humans Liver - diagnostic imaging Liver - physiology Male Middle Aged Prospective Studies Reference Standards Reproducibility of Results Young Adult |
| Title | Liver Stiffness Measurements with MR Elastography: Agreement and Repeatability across Imaging Systems, Field Strengths, and Pulse Sequences |
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