Two-dimensional Shear-Wave Elastography Performance in the Noninvasive Evaluation of Liver Fibrosis in Patients with Chronic Hepatitis B: Comparison with Serum Fibrosis Indexes
Purpose To investigate the value of two-dimensional (2D) shear-wave elastography (SWE) in the assessment of hepatic fibrosis in patients with chronic hepatitis B (CHB) and to compare the diagnostic performance of this modality with that of liver fibrosis indexes. Materials and Methods The ethics com...
Uložené v:
| Vydané v: | Radiology Ročník 283; číslo 3; s. 873 - 882 |
|---|---|
| Hlavní autori: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
01.06.2017
|
| Predmet: | |
| ISSN: | 1527-1315 |
| On-line prístup: | Zistit podrobnosti o prístupe |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Purpose To investigate the value of two-dimensional (2D) shear-wave elastography (SWE) in the assessment of hepatic fibrosis in patients with chronic hepatitis B (CHB) and to compare the diagnostic performance of this modality with that of liver fibrosis indexes. Materials and Methods The ethics committee approved this study, and informed consent was obtained. From July 2015 to May 2016, 539 subjects who underwent partial hepatectomy were divided into groups according to the Scheuer system by using a resected liver specimen. All patients were examined with 2D SWE and underwent preoperative serologic testing to measure liver stiffness and values of serum fibrosis models, which were compared with histologic findings. Performance of noninvasive methods was determined for index (304 patients) and validation (155 patients) cohorts by using areas under the receiver operating characteristic curve (AUCs). Results For association with substantial fibrosis (≥S2), severe fibrosis (≥S3), and cirrhosis (S4) in the index cohort, the optimal cutoff values of liver stiffness were 7.6, 9.2, and 10.4 kPa, respectively, and AUC values were 0.97, 0.96, and 0.98, respectively. The 2D SWE findings, aspartate transaminase-to-platelet ratio index (APRI), fibrosis index based on the four factors (FIB-4), King's score, and Forns index significantly correlated with hepatic fibrosis stages (ρ = 0.88, ρ = 0.41, ρ = 0.40, ρ = 0.43 and ρ = 0.45, respectively; P < .05). The AUCs for APRI, FIB-4, King's score, and Forns index were 0.77, 0.73, 0.79, and 0.77, respectively, in the diagnosis of substantial fibrosis and 0.70, 0.71, 0.72, and 0.74, respectively, in the diagnosis of cirrhosis. In the validation cohort, AUCs of noninvasive methods used to assess different fibrosis stages did not significantly differ from those for the index cohort. AUCs of 2D SWE in the diagnosis of substantial fibrosis, severe fibrosis, and cirrhosis were 0.97, 0.97, and 0.98, respectively, which were significantly higher than those in serum models (P < .05). Conclusion The 2D SWE protocol could be used to predict substantial fibrosis, severe fibrosis, and cirrhosis in patients with CHB with notably higher diagnostic accuracy than that attained with serum fibrosis models.
RSNA, 2016. |
|---|---|
| AbstractList | Purpose To investigate the value of two-dimensional (2D) shear-wave elastography (SWE) in the assessment of hepatic fibrosis in patients with chronic hepatitis B (CHB) and to compare the diagnostic performance of this modality with that of liver fibrosis indexes. Materials and Methods The ethics committee approved this study, and informed consent was obtained. From July 2015 to May 2016, 539 subjects who underwent partial hepatectomy were divided into groups according to the Scheuer system by using a resected liver specimen. All patients were examined with 2D SWE and underwent preoperative serologic testing to measure liver stiffness and values of serum fibrosis models, which were compared with histologic findings. Performance of noninvasive methods was determined for index (304 patients) and validation (155 patients) cohorts by using areas under the receiver operating characteristic curve (AUCs). Results For association with substantial fibrosis (≥S2), severe fibrosis (≥S3), and cirrhosis (S4) in the index cohort, the optimal cutoff values of liver stiffness were 7.6, 9.2, and 10.4 kPa, respectively, and AUC values were 0.97, 0.96, and 0.98, respectively. The 2D SWE findings, aspartate transaminase-to-platelet ratio index (APRI), fibrosis index based on the four factors (FIB-4), King's score, and Forns index significantly correlated with hepatic fibrosis stages (ρ = 0.88, ρ = 0.41, ρ = 0.40, ρ = 0.43 and ρ = 0.45, respectively; P < .05). The AUCs for APRI, FIB-4, King's score, and Forns index were 0.77, 0.73, 0.79, and 0.77, respectively, in the diagnosis of substantial fibrosis and 0.70, 0.71, 0.72, and 0.74, respectively, in the diagnosis of cirrhosis. In the validation cohort, AUCs of noninvasive methods used to assess different fibrosis stages did not significantly differ from those for the index cohort. AUCs of 2D SWE in the diagnosis of substantial fibrosis, severe fibrosis, and cirrhosis were 0.97, 0.97, and 0.98, respectively, which were significantly higher than those in serum models (P < .05). Conclusion The 2D SWE protocol could be used to predict substantial fibrosis, severe fibrosis, and cirrhosis in patients with CHB with notably higher diagnostic accuracy than that attained with serum fibrosis models. © RSNA, 2016. Purpose To investigate the value of two-dimensional (2D) shear-wave elastography (SWE) in the assessment of hepatic fibrosis in patients with chronic hepatitis B (CHB) and to compare the diagnostic performance of this modality with that of liver fibrosis indexes. Materials and Methods The ethics committee approved this study, and informed consent was obtained. From July 2015 to May 2016, 539 subjects who underwent partial hepatectomy were divided into groups according to the Scheuer system by using a resected liver specimen. All patients were examined with 2D SWE and underwent preoperative serologic testing to measure liver stiffness and values of serum fibrosis models, which were compared with histologic findings. Performance of noninvasive methods was determined for index (304 patients) and validation (155 patients) cohorts by using areas under the receiver operating characteristic curve (AUCs). Results For association with substantial fibrosis (≥S2), severe fibrosis (≥S3), and cirrhosis (S4) in the index cohort, the optimal cutoff values of liver stiffness were 7.6, 9.2, and 10.4 kPa, respectively, and AUC values were 0.97, 0.96, and 0.98, respectively. The 2D SWE findings, aspartate transaminase-to-platelet ratio index (APRI), fibrosis index based on the four factors (FIB-4), King's score, and Forns index significantly correlated with hepatic fibrosis stages (ρ = 0.88, ρ = 0.41, ρ = 0.40, ρ = 0.43 and ρ = 0.45, respectively; P < .05). The AUCs for APRI, FIB-4, King's score, and Forns index were 0.77, 0.73, 0.79, and 0.77, respectively, in the diagnosis of substantial fibrosis and 0.70, 0.71, 0.72, and 0.74, respectively, in the diagnosis of cirrhosis. In the validation cohort, AUCs of noninvasive methods used to assess different fibrosis stages did not significantly differ from those for the index cohort. AUCs of 2D SWE in the diagnosis of substantial fibrosis, severe fibrosis, and cirrhosis were 0.97, 0.97, and 0.98, respectively, which were significantly higher than those in serum models (P < .05). Conclusion The 2D SWE protocol could be used to predict substantial fibrosis, severe fibrosis, and cirrhosis in patients with CHB with notably higher diagnostic accuracy than that attained with serum fibrosis models. RSNA, 2016. |
| Author | Wang, Wenping Zhuang, Yuan Ding, Hong Zhang, Yue Sun, Huichuan Xu, Chen |
| Author_xml | – sequence: 1 givenname: Yuan surname: Zhuang fullname: Zhuang, Yuan organization: From the Departments of Ultrasound (Y. Zhuang, H.D., Y. Zhang, W.W.), Surgery (H.S.), and Pathology (C.X.), Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China – sequence: 2 givenname: Hong surname: Ding fullname: Ding, Hong organization: From the Departments of Ultrasound (Y. Zhuang, H.D., Y. Zhang, W.W.), Surgery (H.S.), and Pathology (C.X.), Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China – sequence: 3 givenname: Yue surname: Zhang fullname: Zhang, Yue organization: From the Departments of Ultrasound (Y. Zhuang, H.D., Y. Zhang, W.W.), Surgery (H.S.), and Pathology (C.X.), Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China – sequence: 4 givenname: Huichuan surname: Sun fullname: Sun, Huichuan organization: From the Departments of Ultrasound (Y. Zhuang, H.D., Y. Zhang, W.W.), Surgery (H.S.), and Pathology (C.X.), Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China – sequence: 5 givenname: Chen surname: Xu fullname: Xu, Chen organization: From the Departments of Ultrasound (Y. Zhuang, H.D., Y. Zhang, W.W.), Surgery (H.S.), and Pathology (C.X.), Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China – sequence: 6 givenname: Wenping surname: Wang fullname: Wang, Wenping organization: From the Departments of Ultrasound (Y. Zhuang, H.D., Y. Zhang, W.W.), Surgery (H.S.), and Pathology (C.X.), Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27982760$$D View this record in MEDLINE/PubMed |
| BookMark | eNpFkMtOwzAQRS0Eorw-gA3ykk2Kx3k57KCiFKkCJIpYVq4zIUaJHeykwF_xibg8xGpGd86cxd0n28YaJOQY2BggEWdOlto2Y84gg4xBDFtkD1KeR2FNR2Tf-xfGIElFvktGPC8EzzO2Rz4XbzYqdYvGa2tkQx9qlC56kmukV430vX12sqs_6D26yrpWGoVUG9rXSG-t0WYtvd6wa9kMsg8Oais6D5GjU71y1mu_4e_DDU3v6ZvuazqpXfhVdIZdyPuAXJ7TiW076bQPim_oAd3Q_ktuTInv6A_JTiUbj0e_84A8Tq8Wk1k0v7u-mVzMIxUz6COeYBGaKLlgQikoMK7iSkGeJwBxnCYiXomcoVQlFGVeFCBWWVkxVFIUFU9TfkBOf7yds68D-n7Zaq-waaRBO_gliJRnBWNcBPTkFx1WLZbLzulWuo_lX8v8C-V1gxI |
| CitedBy_id | crossref_primary_10_1111_jvim_15598 crossref_primary_10_1016_j_ejrad_2020_109386 crossref_primary_10_1016_j_hbpd_2020_05_008 crossref_primary_10_3390_diagnostics13091646 crossref_primary_10_1177_2050640619854671 crossref_primary_10_1007_s12072_020_10017_1 crossref_primary_10_1155_2021_8393697 crossref_primary_10_1136_gutjnl_2018_317593 crossref_primary_10_3748_wjg_v30_i27_3314 crossref_primary_10_1080_17474124_2020_1779589 crossref_primary_10_3748_wjg_v25_i20_2503 crossref_primary_10_3390_v15040846 crossref_primary_10_1016_j_ultrasmedbio_2024_11_017 crossref_primary_10_1002_smtd_202301634 crossref_primary_10_3389_fimmu_2022_868809 crossref_primary_10_1159_000546574 crossref_primary_10_1016_j_acra_2021_07_005 crossref_primary_10_1002_bmm2_12123 crossref_primary_10_1016_j_ejrad_2022_110248 crossref_primary_10_3350_cmh_2024_0506 crossref_primary_10_1016_j_ultrasmedbio_2017_07_003 crossref_primary_10_1080_17474124_2021_1880894 crossref_primary_10_1111_jpc_15751 crossref_primary_10_1111_1751_2980_12991 crossref_primary_10_1002_jum_15378 crossref_primary_10_1097_RUQ_0000000000000438 crossref_primary_10_1111_imj_15603 crossref_primary_10_1186_s13244_020_0839_y crossref_primary_10_1007_s00330_017_5245_6 crossref_primary_10_1002_ajum_12244 crossref_primary_10_1002_jcu_23577 crossref_primary_10_1007_s00330_019_06595_w crossref_primary_10_1055_a_1376_6734 crossref_primary_10_1177_2050640618792819 crossref_primary_10_1111_jocs_15553 crossref_primary_10_1016_j_cca_2021_11_004 crossref_primary_10_1016_j_jbi_2022_103986 crossref_primary_10_2147_JHC_S372577 crossref_primary_10_1016_j_ultrasmedbio_2020_02_012 crossref_primary_10_1177_21501351231154216 crossref_primary_10_1186_s12880_023_00977_9 crossref_primary_10_1007_s11547_018_0905_4 crossref_primary_10_3389_fmed_2022_844558 crossref_primary_10_1136_gutjnl_2018_316204 crossref_primary_10_1002_smll_202410638 crossref_primary_10_3390_diagnostics15010062 crossref_primary_10_1016_j_gastrohep_2019_11_009 crossref_primary_10_1080_17474124_2018_1412257 crossref_primary_10_1007_s00330_019_06335_0 crossref_primary_10_1007_s00261_019_02295_7 crossref_primary_10_1007_s00261_021_03374_4 crossref_primary_10_3748_wjg_v25_i25_3256 crossref_primary_10_1016_j_aohep_2024_101743 crossref_primary_10_1097_SLA_0000000000002942 crossref_primary_10_1007_s11605_017_3443_9 crossref_primary_10_1186_s12880_021_00601_8 crossref_primary_10_1111_petr_13815 crossref_primary_10_3233_CH_211223 crossref_primary_10_3748_wjg_v31_i4_98886 crossref_primary_10_14366_usg_21136 crossref_primary_10_3748_wjg_v26_i46_7416 crossref_primary_10_3389_fped_2022_918145 crossref_primary_10_2147_IJGM_S364216 crossref_primary_10_1007_s00330_018_5621_x crossref_primary_10_1016_j_gastre_2019_11_006 crossref_primary_10_3233_CH_221511 crossref_primary_10_1007_s40620_023_01856_w crossref_primary_10_1016_j_iliver_2022_02_002 crossref_primary_10_1148_radiol_2018172479 crossref_primary_10_1002_hep4_1859 crossref_primary_10_3748_wjg_v24_i9_957 crossref_primary_10_1007_s11901_018_0439_1 crossref_primary_10_1016_j_ultrasmedbio_2017_09_011 crossref_primary_10_1007_s00261_018_1860_1 crossref_primary_10_3348_kjr_2020_0885 crossref_primary_10_1038_s41598_022_08955_x crossref_primary_10_1016_S2468_1253_24_00437_0 crossref_primary_10_1093_bjr_tqad030 crossref_primary_10_1097_MEG_0000000000002763 crossref_primary_10_1002_jum_16559 crossref_primary_10_1007_s12072_022_10303_0 crossref_primary_10_1097_HEP_0000000000000566 crossref_primary_10_1002_jum_16541 crossref_primary_10_1186_s12880_022_00819_0 crossref_primary_10_1016_j_crad_2022_06_003 crossref_primary_10_1097_RLI_0000000000001001 crossref_primary_10_1111_hepr_13306 crossref_primary_10_1016_j_mri_2019_03_002 crossref_primary_10_1186_s12876_021_01727_3 crossref_primary_10_3390_ani13223446 crossref_primary_10_1148_radiol_2018170601 crossref_primary_10_12998_wjcc_v8_i17_3730 crossref_primary_10_1097_RUQ_0000000000000485 crossref_primary_10_1016_j_crad_2024_106750 crossref_primary_10_1016_j_dld_2020_02_002 crossref_primary_10_1186_s12880_025_01846_3 crossref_primary_10_1016_j_ejrad_2020_108839 crossref_primary_10_1111_chd_12558 crossref_primary_10_3748_wjg_v24_i34_3849 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1148/radiol.2016160131 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1527-1315 |
| EndPage | 882 |
| ExternalDocumentID | 27982760 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | --- .55 .GJ 123 18M 1CY 1KJ 29P 2WC 34G 39C 4.4 53G 5RE 6NX 6PF 7FM AAEJM AAQQT AAWTL ABDPE ABHFT ABOCM ACFQH ACGFO ACJAN ACRZS ADBBV AENEX AENYM AFFNX AFOSN AJJEV AJWWR ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P F9R GX1 H13 J5H KO8 L7B LMP LSO MJL MV1 N4W NPM OK1 P2P R.V RKKAF RXW SJN TAE TR2 TRS TWZ VXZ W8F WH7 WOQ X7M YQI YQJ ZGI ZKG ZVN ZXP 7X8 |
| ID | FETCH-LOGICAL-c301t-24e9161d2808cc19e3f3fc177411335483b870eacd19d79918b6df0eca89f2552 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 100 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000401898400027&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| IngestDate | Fri Sep 05 13:05:33 EDT 2025 Wed Feb 19 02:40:21 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c301t-24e9161d2808cc19e3f3fc177411335483b870eacd19d79918b6df0eca89f2552 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 27982760 |
| PQID | 1852690028 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_1852690028 pubmed_primary_27982760 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-06-00 20170601 |
| PublicationDateYYYYMMDD | 2017-06-01 |
| PublicationDate_xml | – month: 06 year: 2017 text: 2017-06-00 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Radiology |
| PublicationTitleAlternate | Radiology |
| PublicationYear | 2017 |
| SSID | ssj0014587 |
| Score | 2.534146 |
| Snippet | Purpose To investigate the value of two-dimensional (2D) shear-wave elastography (SWE) in the assessment of hepatic fibrosis in patients with chronic hepatitis... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 873 |
| SubjectTerms | Elasticity Imaging Techniques - methods Female Hepatitis B, Chronic - complications Humans Liver Cirrhosis - blood Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - etiology Male Middle Aged |
| Title | Two-dimensional Shear-Wave Elastography Performance in the Noninvasive Evaluation of Liver Fibrosis in Patients with Chronic Hepatitis B: Comparison with Serum Fibrosis Indexes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27982760 https://www.proquest.com/docview/1852690028 |
| Volume | 283 |
| WOSCitedRecordID | wos000401898400027&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LSsNAFB3Uirjx_agvRnA7tEkmmYkbUWmpYEsXFbsryTygC5PatPW3_ETvTabtShDcZBFmQsidnDn3MecScicTY0SoAhakNmQ8DFOWeKlilkea89AYa3TZbEL0enI4jPsu4Fa4ssolJpZArXOFMfIGHvIFTw62w4fJJ8OuUZhddS00NkktACqDq1oM11kEHkrhMpnA-hvTRI9zTDcAy4lQZ-Z3VlnuLu39_77XAdlzvJI-VgvhkGyY7IjsdF3m_Jh8D75yplHKv5LhoGUra_aeLAxtAYOeOelq2l-fJKDjjAI_pD0M2S4SLHSnrZU6OM0tfcWqDtoGlzsvxgWO71c6rQXFAC910ru0Y7BwewZDnu7p86r1YTUI4Gr-sX7IC-o3muKEvLVbg-cOc90amAKQmDGfG6CanvZlUyrlxSawgVUe0EsP_GBwjIIUsAFwXnuxFkBLZRpp2zQqkbEFx8Y_JVtZnplzQoWWPOBpBNiRcqn8VETcRsZvJhzvijq5XdpiBH8DpjiSzOTzYrS2Rp2cVQYdTSrZjpEvYumLqHnxh9mXZNfH_bsMt1yRmgUsMNdkWy3gU01vymUG116_-wNiUuKe |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Two-dimensional+Shear-Wave+Elastography+Performance+in+the+Noninvasive+Evaluation+of+Liver+Fibrosis+in+Patients+with+Chronic+Hepatitis+B%3A+Comparison+with+Serum+Fibrosis+Indexes&rft.jtitle=Radiology&rft.au=Zhuang%2C+Yuan&rft.au=Ding%2C+Hong&rft.au=Zhang%2C+Yue&rft.au=Sun%2C+Huichuan&rft.date=2017-06-01&rft.eissn=1527-1315&rft.volume=283&rft.issue=3&rft.spage=873&rft_id=info:doi/10.1148%2Fradiol.2016160131&rft_id=info%3Apmid%2F27982760&rft_id=info%3Apmid%2F27982760&rft.externalDocID=27982760 |