Nocturnal low glucose detection in healthy elderly from one-lead ECG using convolutional denoising autoencoders
Hypoglycemia is a condition caused by low blood glucose levels, mainly affecting people with diabetes. Low levels of blood glucose can be dangerous, causing multiple complications over time. Hypoglycemia affects the repolarization characteristics of the heart. This study presents a personalized, dee...
Gespeichert in:
| Veröffentlicht in: | Biomedical signal processing and control Jg. 62; S. 102054 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Elsevier Ltd
01.09.2020
|
| Schlagworte: | |
| ISSN: | 1746-8094, 1746-8108 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Hypoglycemia is a condition caused by low blood glucose levels, mainly affecting people with diabetes. Low levels of blood glucose can be dangerous, causing multiple complications over time. Hypoglycemia affects the repolarization characteristics of the heart. This study presents a personalized, deep learning-based approach that enables nocturnal hypoglycemia detection using raw electrocardiogram (ECG) signals, recorded with non-invasive, wearable devices. The study was carried out in a calorimeter room during 24–36 h monitoring on twenty-five, healthy, elderly participants. The results of this study (accuracy of ≈90%) provide evidence for the feasibility of a non-invasive, ECG-based hypoglycemia alarming system. Moreover, leveraging an unsupervised method (i.e. convolutional denoising autoencoder) and visualizing the ECG heartbeats in the embeddings space, clear heartbeats clusters grouped by glucose levels could be determined, showing that specific patterns in the input heartbeats are indeed glucose discriminative and the autoencoder could successfully capture those patterns. |
|---|---|
| AbstractList | Hypoglycemia is a condition caused by low blood glucose levels, mainly affecting people with diabetes. Low levels of blood glucose can be dangerous, causing multiple complications over time. Hypoglycemia affects the repolarization characteristics of the heart. This study presents a personalized, deep learning-based approach that enables nocturnal hypoglycemia detection using raw electrocardiogram (ECG) signals, recorded with non-invasive, wearable devices. The study was carried out in a calorimeter room during 24–36 h monitoring on twenty-five, healthy, elderly participants. The results of this study (accuracy of ≈90%) provide evidence for the feasibility of a non-invasive, ECG-based hypoglycemia alarming system. Moreover, leveraging an unsupervised method (i.e. convolutional denoising autoencoder) and visualizing the ECG heartbeats in the embeddings space, clear heartbeats clusters grouped by glucose levels could be determined, showing that specific patterns in the input heartbeats are indeed glucose discriminative and the autoencoder could successfully capture those patterns. |
| ArticleNumber | 102054 |
| Author | Griffen, Corbin Hattersley, John Porumb, Mihaela Pecchia, Leandro |
| Author_xml | – sequence: 1 givenname: Mihaela surname: Porumb fullname: Porumb, Mihaela email: M.Porumb@warwick.ac.uk organization: University of Warwick, Coventry CV4 7AL, UK – sequence: 2 givenname: Corbin surname: Griffen fullname: Griffen, Corbin email: griffenc@uni.coventry.ac.uk organization: Coventry University, Centre for Sport, Exercise and Life Sciences, Coventry CV4 1DS, UK – sequence: 3 givenname: John surname: Hattersley fullname: Hattersley, John email: John.Hattersley@uhcw.nhs.uk organization: Human Metabolic Research Unit, Universities of Coventry and Warwickshire NHS Trust and University of Warwick, Warwick, UK – sequence: 4 givenname: Leandro surname: Pecchia fullname: Pecchia, Leandro email: L.Pecchia@warwick.ac.uk organization: University of Warwick, Coventry CV4 7AL, UK |
| BookMark | eNp9kMFOAjEQhhuDiYC-gKe-wGLb7S5L4sUQRBOiFz03ZXYWSkpL2l0Mb29X9OKB0zR_883k_0Zk4LxDQu45m3DGy4fdZB0PMBFM9IFghbwiQz6VZVZxVg3-3mwmb8goxh1jsppyOST-zUPbBacttf6LbmwHPiKtsUVojXfUOLpFbdvtiaKtMdgTbYLf03Q_s6hrupgvaReN21Dw7uht12NpXY3Om59cd61HBz7R8ZZcN9pGvPudY_L5vPiYv2Sr9-Xr_GmVQc5Ym2GpMWeihAolw3UjOSLPcwFlATOApoBclJxXDS_WKdDrWnIx4zkWupQi_Y6JOO-F4GMM2KhDMHsdTooz1StTO9UrU70ydVaWoOofBKbVfZ82aGMvo49nFFOpo8GgIphUGmsTkklVe3MJ_wbAr4v6 |
| CitedBy_id | crossref_primary_10_1016_j_bspc_2024_106065 crossref_primary_10_1016_j_bspc_2025_107750 crossref_primary_10_1007_s40200_025_01648_y crossref_primary_10_1016_j_compag_2022_107455 crossref_primary_10_1016_j_bspc_2022_104194 crossref_primary_10_1136_bmjopen_2022_067899 crossref_primary_10_3389_fbioe_2022_876672 crossref_primary_10_2196_36010 crossref_primary_10_1016_j_compbiomed_2024_109422 crossref_primary_10_1016_j_compbiomed_2023_107908 crossref_primary_10_1002_cnm_3799 crossref_primary_10_1142_S0218126625300053 crossref_primary_10_3233_THC_220316 crossref_primary_10_1109_RBME_2022_3154893 crossref_primary_10_1109_ACCESS_2021_3058809 crossref_primary_10_1109_TNNLS_2023_3279383 crossref_primary_10_1109_JBHI_2021_3072628 crossref_primary_10_1007_s12553_022_00719_x crossref_primary_10_1136_bmjmed_2022_000193 crossref_primary_10_1016_j_ijimpeng_2023_104825 |
| Cites_doi | 10.1089/dia.2014.0378 10.1109/TBME.2015.2468589 10.1177/1932296813511747 10.1109/TBME.2017.2718179 10.2337/diabetes.52.6.1469 10.1111/j.1542-474X.2008.00208.x 10.1038/s41591-018-0240-2 10.2337/db13-0468 10.1016/j.isatra.2016.05.008 10.1002/(SICI)1096-9136(199708)14:8<648::AID-DIA418>3.0.CO;2-1 10.1007/s13300-016-0223-6 10.2337/dc17-S005 10.1109/TCYB.2016.2536638 10.1088/0967-3334/32/6/003 10.1089/dia.2018.0113 10.1002/clc.22288 10.1126/science.1127647 10.1016/j.artmed.2012.04.003 10.1016/S0140-6736(16)31535-5 10.1046/j.1365-2125.2003.01726.x 10.1038/s41598-019-56927-5 10.2337/dc11-1739 10.1109/CEC.2014.6900229 10.1109/TBME.2016.2631620 10.1007/s00500-015-1809-z 10.1007/s00125-007-0902-y 10.2337/diacare.26.5.1485 10.1109/TPAMI.2013.50 10.1109/ACCESS.2018.2807700 10.1136/hrt.79.5.493 10.1088/0967-3334/21/2/309 10.1038/s41591-018-0268-3 10.1007/s00125-003-1292-4 |
| ContentType | Journal Article |
| Copyright | 2020 Elsevier Ltd |
| Copyright_xml | – notice: 2020 Elsevier Ltd |
| DBID | AAYXX CITATION |
| DOI | 10.1016/j.bspc.2020.102054 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 1746-8108 |
| ExternalDocumentID | 10_1016_j_bspc_2020_102054 S174680942030210X |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1~. 1~5 23N 4.4 457 4G. 5GY 5VS 6J9 7-5 71M 8P~ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO AAYFN ABBOA ABFNM ABFRF ABJNI ABMAC ABXDB ABYKQ ACDAQ ACGFO ACGFS ACNNM ACRLP ACZNC ADBBV ADEZE ADMUD ADTZH AEBSH AECPX AEFWE AEKER AENEX AFKWA AFTJW AGHFR AGUBO AGYEJ AHJVU AHZHX AIALX AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AOUOD AXJTR BJAXD BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA GBOLZ HZ~ IHE J1W JJJVA KOM M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SDF SDG SES SPC SPCBC SST SSV SSZ T5K UNMZH ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD |
| ID | FETCH-LOGICAL-c300t-e6ae3026c8e40ebf41ee1332c65c9ccf5c326118f15bc9cabd412913e5a6425c3 |
| ISICitedReferencesCount | 25 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000575379300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1746-8094 |
| IngestDate | Tue Nov 18 22:35:32 EST 2025 Sat Nov 29 07:04:05 EST 2025 Fri Feb 23 02:47:56 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Convolutional neural networks Convolutional denoising autoencoder Nocturnal hypoglycemia |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c300t-e6ae3026c8e40ebf41ee1332c65c9ccf5c326118f15bc9cabd412913e5a6425c3 |
| ParticipantIDs | crossref_primary_10_1016_j_bspc_2020_102054 crossref_citationtrail_10_1016_j_bspc_2020_102054 elsevier_sciencedirect_doi_10_1016_j_bspc_2020_102054 |
| PublicationCentury | 2000 |
| PublicationDate | September 2020 2020-09-00 |
| PublicationDateYYYYMMDD | 2020-09-01 |
| PublicationDate_xml | – month: 09 year: 2020 text: September 2020 |
| PublicationDecade | 2020 |
| PublicationTitle | Biomedical signal processing and control |
| PublicationYear | 2020 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Porumb, Stranges, Pescapè, Pecchia (bib0100) 2020; 10 Sanon, Sanon, Kanakia, Yu, Araj, Oliveros, Chilton (bib0055) 2014; 37 Du, Xiong, Wu, Zhang, Zhang, Tao (bib0160) 2017; 47 Yazdani, Fallet, Vesin (bib0215) 2018; 65 Glorot, Bordes, Bengio (bib0225) 2011 Attia, Kapa, Lopez-Jimenez, McKie, Ladewig, Satam, Pellikka, Enriquez-Sarano, Noseworthy, Munger, Asirvatham, Scott, Carter, Friedman (bib0115) 2019; 25 Ling, San, Lam, Nguyen (bib0085) 2014 Robinson, Harris, Ireland, Lindholm, Heller (bib0025) 2003; 55 Laitinen, Lyyra-Laitinen, Huopio, Vauhkonen, Halonen, Hartikainen, Niskanen, Laakso (bib0035) 2008; 13 American Diabetes Association (bib0210) 2017; 40 Lipponen, Kemppainen, Karjalainen, Laitinen, Mikola, Kärki, Tarvainen (bib0010) 2011; 32 Bolinder, Antuna, Geelhoed-Duijvestijn, Kröger, Weitgasser (bib0185) 2016; 388 Xia, Zhang, Xu, Gao, Zhang, Liu, Li (bib0130) 2018; 6 Ireland, Robinson, Heller, Marques, Harris (bib0020) 2000; 21 Bridle (bib0175) 1990 Marques, George, Peacey, Harris, Macdonald, Cochrane, Heller (bib0050) 1997; 14 Hannun, Rajpurkar, Haghpanahi, Tison, Bourn, Turakhia, Ng (bib0105) 2019; 25 Robinson, Harris, Ireland, Lee, Newman, Heller (bib0015) 2003; 52 Bengio, Courville, Vincent (bib0125) 2013; 35 Ling, San, Lam, Nguyen (bib0075) 2017; 21 Hinton (bib0145) 2006; 313 Gogna, Majumdar, Ward (bib0135) 2017; 64 Ochiai, Takahashi, Fukazawa (bib0140) 2018 Bailey, Bode, Christiansen, Klaff, Alva (bib0200) 2015; 17 Pourbabaee, Roshtkhari, Khorasani (bib0120) 2017; PP Robinson, Harris, Ireland, Macdonald, Heller (bib0045) 2004; 47 Masci, Meier, Ciresan, Schmidhuber (bib0165) 2011 Haak, Hanaire, Ajjan, Hermanns, Riveline, Rayman (bib0190) 2017; 8 Koivikko, Karsikas, Salmela, Tapanainen, Ruokonen, Seppänen, Huikuri, Perkiömäki (bib0030) 2008; 51 Ling, San, Nguyen (bib0080) 2016; 64 Gertsch (bib0095) 2004 Desouza, Salazar, Cheong, Murgo, Fonseca (bib0060) 2003; 26 Maaten, Hinton (bib0180) 2008; 9 Hoss, Budiman, Liu, Christiansen (bib0195) 2014; 8 Nakagawa, Iwao, Ishida, Yonemochi, Fujino, Saikawa, Ito (bib0205) 1998; 79 Turchenko, Luczak (bib0170) 2017 Kiranyaz, Ince, Gabbouj (bib0110) 2016; 63 Ratner (bib0005) 2018; 20 San, Ling, Nguyen (bib0070) 2016 Maaten (bib0230) 2009 Chow, Bernjak, Williams, Fawdry, Hibbert, Freeman, Sheridan, Heller (bib0065) 2014; 63 Vincent, Larochelle, Bengio, Manzagol (bib0155) 2008 Gruden, Giunti, Barutta, Chaturvedi, Witte, Tricarico, Fuller, Cavallo Perin, Bruno (bib0040) 2012; 35 Ling, Nguyen (bib0090) 2012; 55 Vincent, Larochelle, Lajoie, Bengio, Manzagol (bib0150) 2010; 11 Kingma, Ba (bib0220) 2015 Lipponen (10.1016/j.bspc.2020.102054_bib0010) 2011; 32 Ratner (10.1016/j.bspc.2020.102054_bib0005) 2018; 20 Desouza (10.1016/j.bspc.2020.102054_bib0060) 2003; 26 Bolinder (10.1016/j.bspc.2020.102054_bib0185) 2016; 388 Ling (10.1016/j.bspc.2020.102054_bib0080) 2016; 64 Sanon (10.1016/j.bspc.2020.102054_bib0055) 2014; 37 Maaten (10.1016/j.bspc.2020.102054_bib0180) 2008; 9 Robinson (10.1016/j.bspc.2020.102054_bib0045) 2004; 47 Glorot (10.1016/j.bspc.2020.102054_bib0225) 2011 Gogna (10.1016/j.bspc.2020.102054_bib0135) 2017; 64 Maaten (10.1016/j.bspc.2020.102054_bib0230) 2009 American Diabetes Association (10.1016/j.bspc.2020.102054_bib0210) 2017; 40 Attia (10.1016/j.bspc.2020.102054_bib0115) 2019; 25 Hoss (10.1016/j.bspc.2020.102054_bib0195) 2014; 8 Nakagawa (10.1016/j.bspc.2020.102054_bib0205) 1998; 79 Robinson (10.1016/j.bspc.2020.102054_bib0025) 2003; 55 Du (10.1016/j.bspc.2020.102054_bib0160) 2017; 47 Ling (10.1016/j.bspc.2020.102054_bib0090) 2012; 55 Chow (10.1016/j.bspc.2020.102054_bib0065) 2014; 63 Ling (10.1016/j.bspc.2020.102054_bib0085) 2014 Masci (10.1016/j.bspc.2020.102054_bib0165) 2011 Bridle (10.1016/j.bspc.2020.102054_bib0175) 1990 Haak (10.1016/j.bspc.2020.102054_bib0190) 2017; 8 Yazdani (10.1016/j.bspc.2020.102054_bib0215) 2018; 65 Marques (10.1016/j.bspc.2020.102054_bib0050) 1997; 14 Ling (10.1016/j.bspc.2020.102054_bib0075) 2017; 21 Xia (10.1016/j.bspc.2020.102054_bib0130) 2018; 6 Vincent (10.1016/j.bspc.2020.102054_bib0155) 2008 Laitinen (10.1016/j.bspc.2020.102054_bib0035) 2008; 13 Kingma (10.1016/j.bspc.2020.102054_bib0220) 2015 Hannun (10.1016/j.bspc.2020.102054_bib0105) 2019; 25 Porumb (10.1016/j.bspc.2020.102054_bib0100) 2020; 10 Pourbabaee (10.1016/j.bspc.2020.102054_bib0120) 2017; PP Vincent (10.1016/j.bspc.2020.102054_bib0150) 2010; 11 Ireland (10.1016/j.bspc.2020.102054_bib0020) 2000; 21 Gertsch (10.1016/j.bspc.2020.102054_bib0095) 2004 Koivikko (10.1016/j.bspc.2020.102054_bib0030) 2008; 51 Gruden (10.1016/j.bspc.2020.102054_bib0040) 2012; 35 Bengio (10.1016/j.bspc.2020.102054_bib0125) 2013; 35 Hinton (10.1016/j.bspc.2020.102054_bib0145) 2006; 313 Bailey (10.1016/j.bspc.2020.102054_bib0200) 2015; 17 Turchenko (10.1016/j.bspc.2020.102054_bib0170) 2017 San (10.1016/j.bspc.2020.102054_bib0070) 2016 Kiranyaz (10.1016/j.bspc.2020.102054_bib0110) 2016; 63 Robinson (10.1016/j.bspc.2020.102054_bib0015) 2003; 52 Ochiai (10.1016/j.bspc.2020.102054_bib0140) 2018 |
| References_xml | – start-page: 227 year: 1990 end-page: 236 ident: bib0175 article-title: Probabilistic interpretation of feedforward classification network outputs, with relationships to statistical pattern recognition publication-title: Neurocomputing, NATO ASI Series – volume: 9 start-page: 2579 year: 2008 end-page: 2605 ident: bib0180 article-title: Visualizing data using t-SNE publication-title: J. Mach. Learn. Res. – volume: 8 start-page: 55 year: 2017 end-page: 73 ident: bib0190 article-title: Flash glucose-sensing technology as a replacement for blood glucose monitoring for the management of insulin-treated type 2 diabetes: a multicenter, open-label randomized controlled trial publication-title: Diabetes Ther. – volume: 63 start-page: 1738 year: 2014 end-page: 1747 ident: bib0065 article-title: Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk publication-title: Diabetes – volume: 10 start-page: 1 year: 2020 end-page: 16 ident: bib0100 article-title: Precision medicine and artificial intelligence: a pilot study on deep learning for hypoglycemic events detection based on ECG publication-title: Sci. Rep. – volume: 35 start-page: 1798 year: 2013 end-page: 1828 ident: bib0125 article-title: Representation learning: a review and new perspectives publication-title: IEEE Trans. Pattern Anal. Mach. Intell. – volume: 35 start-page: 125 year: 2012 end-page: 127 ident: bib0040 article-title: QTc interval prolongation is independently associated with severe hypoglycemic attacks in type 1 diabetes from the EURODIAB IDDM complications study publication-title: Diabetes Care – volume: 47 start-page: 312 year: 2004 end-page: 315 ident: bib0045 article-title: Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with type 1 diabetes publication-title: Diabetologia – volume: 37 start-page: 499 year: 2014 end-page: 504 ident: bib0055 article-title: Hypoglycemia from a cardiologist's perspective: cardiovascular effects of hypoglycemia publication-title: Clin. Cardiol. – volume: 17 start-page: 787 year: 2015 end-page: 794 ident: bib0200 article-title: The performance and usability of a factory-calibrated flash glucose monitoring system publication-title: Diabetes Technol. Ther. – volume: 55 start-page: 246 year: 2003 end-page: 251 ident: bib0025 article-title: Comparative effect of human soluble insulin and insulin aspart upon hypoglycaemia-induced alterations in cardiac repolarization publication-title: Br. J. Clin. Pharmacol. – volume: 25 start-page: 65 year: 2019 ident: bib0105 article-title: Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network publication-title: Nat. Med. – volume: 20 year: 2018 ident: bib0005 article-title: Hypoglycemia: new definitions and regulatory implications publication-title: Diabetes Technol. Ther. – volume: 26 start-page: 1485 year: 2003 end-page: 1489 ident: bib0060 article-title: Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring publication-title: Diabetes Care – start-page: 19 year: 2004 end-page: 43 ident: bib0095 article-title: The normal ECG and its (normal) variants publication-title: The ECG: A Two-Step Approach to Diagnosis – start-page: 3503 year: 2016 end-page: 3506 ident: bib0070 article-title: Deep learning framework for detection of hypoglycemic episodes in children with type 1 diabetes publication-title: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2016 – volume: 64 start-page: 440 year: 2016 end-page: 446 ident: bib0080 article-title: Non-invasive hypoglycemia monitoring system using extreme learning machine for Type 1 diabetes publication-title: ISA Trans. – volume: 313 start-page: 504 year: 2006 end-page: 507 ident: bib0145 article-title: Reducing the dimensionality of data with neural networks publication-title: Science – volume: 13 start-page: 97 year: 2008 end-page: 105 ident: bib0035 article-title: Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects publication-title: Ann. Noninvasive Electrocardiol. – year: 2015 ident: bib0220 article-title: Adam: a method for stochastic optimization publication-title: Proceedings of the 3rd International Conference on Learning Representations – volume: 51 start-page: 426 year: 2008 end-page: 435 ident: bib0030 article-title: Effects of controlled hypoglycaemia on cardiac repolarisation in patients with type 1 diabetes publication-title: Diabetologia – start-page: 52 year: 2011 end-page: 59 ident: bib0165 article-title: Stacked convolutional auto-encoders for hierarchical feature extraction publication-title: Artificial Neural Networks and Machine Learning - ICANN 2011, Lecture Notes in Computer Science – start-page: 315 year: 2011 end-page: 323 ident: bib0225 article-title: Deep sparse rectifier neural networks publication-title: Proceedings of the Fourteenth International Conference on Artificial Intelligence and Statistics – start-page: 384 year: 2009 end-page: 391 ident: bib0230 article-title: Learning a parametric embedding by preserving local structure publication-title: Artificial Intelligence and Statistics – volume: 11 start-page: 3371 year: 2010 end-page: 3408 ident: bib0150 article-title: Stacked denoising autoencoders: learning useful representations in a deep network with a local denoising criterion publication-title: J. Mach. Learn. Res. – volume: 25 start-page: 70 year: 2019 ident: bib0115 article-title: Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram publication-title: Nat. Med. – volume: 55 start-page: 177 year: 2012 end-page: 184 ident: bib0090 article-title: Natural occurrence of nocturnal hypoglycemia detection using hybrid particle swarm optimized fuzzy reasoning model publication-title: Artif. Intell. Med. – volume: 32 start-page: 649 year: 2011 end-page: 660 ident: bib0010 article-title: Dynamic estimation of cardiac repolarization characteristics during hypoglycemia in healthy and diabetic subjects publication-title: Physiol. Meas. – start-page: 651 year: 2017 end-page: 659 ident: bib0170 article-title: Creation of a deep convolutional auto-encoder in Caffe publication-title: 2017 9th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications (IDAACS), vol. 2 – volume: 14 start-page: 648 year: 1997 end-page: 654 ident: bib0050 article-title: Altered ventricular repolarization during hypoglycaemia in patients with diabetes publication-title: Diabet. Med. – start-page: 1238 year: 2014 end-page: 1242 ident: bib0085 article-title: Non-invasive detection of hypoglycemic episodes in Type 1 diabetes using intelligent hybrid rough neural system publication-title: 2014 IEEE Congress on Evolutionary Computation (CEC) – volume: 64 start-page: 2196 year: 2017 end-page: 2205 ident: bib0135 article-title: Semi-supervised stacked label consistent autoencoder for reconstruction and analysis of biomedical signals publication-title: IEEE Trans. Biomed. Eng. – start-page: 7 year: 2018 ident: bib0140 article-title: Arrhythmia detection from 2-lead ECG using convolutional denoising autoencoders publication-title: Proceedings of the 24th ACM SIGKDD Conference on Knowledge Discovery and Data Mining – volume: 63 start-page: 664 year: 2016 end-page: 675 ident: bib0110 article-title: Real-time patient-specific ECG classification by 1-D convolutional neural networks publication-title: IEEE Trans. Biomed. Eng. – volume: PP start-page: 1 year: 2017 end-page: 10 ident: bib0120 article-title: Deep convolutional neural networks and learning ECG features for screening paroxysmal atrial fibrillation patients publication-title: IEEE Trans. Syst. Man Cybern.: Systems – volume: 388 start-page: 2254 year: 2016 end-page: 2263 ident: bib0185 article-title: Novel glucose-sensing technology and hypoglycaemia in type 1 diabetes: a multicentre, non-masked, randomised controlled trial publication-title: Lancet – volume: 21 start-page: 295 year: 2000 end-page: 303 ident: bib0020 article-title: Measurement of high resolution ECG QT interval during controlled euglycaemia and hypoglycaemia publication-title: Physiol. Meas. – volume: 40 start-page: S11 year: 2017 end-page: S24 ident: bib0210 article-title: 2. Classification and diagnosis of diabetes publication-title: Diabetes Care – volume: 47 start-page: 1017 year: 2017 end-page: 1027 ident: bib0160 article-title: Stacked convolutional denoising auto-encoders for feature representation publication-title: IEEE Trans. Cybern. – volume: 52 start-page: 1469 year: 2003 end-page: 1474 ident: bib0015 article-title: Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia publication-title: Diabetes – volume: 21 start-page: 543 year: 2017 end-page: 553 ident: bib0075 article-title: Hypoglycemia detection: multiple regression-based combinational neural logic approach publication-title: Soft Comput. – start-page: 1096 year: 2008 end-page: 1103 ident: bib0155 article-title: Extracting and composing robust features with denoising autoencoders publication-title: Proceedings of the 25th International Conference on Machine Learning, ICML’08 – volume: 65 start-page: 754 year: 2018 end-page: 762 ident: bib0215 article-title: A novel short-term event extraction algorithm for biomedical signals publication-title: IEEE Trans. Biomed. Eng. – volume: 8 start-page: 89 year: 2014 end-page: 94 ident: bib0195 article-title: Feasibility of factory calibration for subcutaneous glucose sensors in subjects with diabetes publication-title: J. Diabetes Sci. Technol. – volume: 6 start-page: 16529 year: 2018 end-page: 16538 ident: bib0130 article-title: An automatic cardiac arrhythmia classification system with wearable electrocardiogram publication-title: IEEE Access – volume: 79 start-page: 493 year: 1998 end-page: 496 ident: bib0205 article-title: Circadian rhythm of the signal averaged electrocardiogram and its relation to heart rate variability in healthy subjects publication-title: Heart – volume: 17 start-page: 787 issue: 11 year: 2015 ident: 10.1016/j.bspc.2020.102054_bib0200 article-title: The performance and usability of a factory-calibrated flash glucose monitoring system publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2014.0378 – volume: 63 start-page: 664 issue: 3 year: 2016 ident: 10.1016/j.bspc.2020.102054_bib0110 article-title: Real-time patient-specific ECG classification by 1-D convolutional neural networks publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2015.2468589 – volume: 8 start-page: 89 issue: 1 year: 2014 ident: 10.1016/j.bspc.2020.102054_bib0195 article-title: Feasibility of factory calibration for subcutaneous glucose sensors in subjects with diabetes publication-title: J. Diabetes Sci. Technol. doi: 10.1177/1932296813511747 – volume: 65 start-page: 754 issue: 4 year: 2018 ident: 10.1016/j.bspc.2020.102054_bib0215 article-title: A novel short-term event extraction algorithm for biomedical signals publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2017.2718179 – volume: 52 start-page: 1469 issue: 6 year: 2003 ident: 10.1016/j.bspc.2020.102054_bib0015 article-title: Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia publication-title: Diabetes doi: 10.2337/diabetes.52.6.1469 – volume: 13 start-page: 97 issue: 2 year: 2008 ident: 10.1016/j.bspc.2020.102054_bib0035 article-title: Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects publication-title: Ann. Noninvasive Electrocardiol. doi: 10.1111/j.1542-474X.2008.00208.x – volume: 25 start-page: 70 issue: 1 year: 2019 ident: 10.1016/j.bspc.2020.102054_bib0115 article-title: Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram publication-title: Nat. Med. doi: 10.1038/s41591-018-0240-2 – volume: 63 start-page: 1738 issue: 5 year: 2014 ident: 10.1016/j.bspc.2020.102054_bib0065 article-title: Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk publication-title: Diabetes doi: 10.2337/db13-0468 – volume: 64 start-page: 440 year: 2016 ident: 10.1016/j.bspc.2020.102054_bib0080 article-title: Non-invasive hypoglycemia monitoring system using extreme learning machine for Type 1 diabetes publication-title: ISA Trans. doi: 10.1016/j.isatra.2016.05.008 – volume: 14 start-page: 648 issue: 8 year: 1997 ident: 10.1016/j.bspc.2020.102054_bib0050 article-title: Altered ventricular repolarization during hypoglycaemia in patients with diabetes publication-title: Diabet. Med. doi: 10.1002/(SICI)1096-9136(199708)14:8<648::AID-DIA418>3.0.CO;2-1 – volume: 8 start-page: 55 issue: 1 year: 2017 ident: 10.1016/j.bspc.2020.102054_bib0190 article-title: Flash glucose-sensing technology as a replacement for blood glucose monitoring for the management of insulin-treated type 2 diabetes: a multicenter, open-label randomized controlled trial publication-title: Diabetes Ther. doi: 10.1007/s13300-016-0223-6 – volume: 40 start-page: S11 issue: Suppl. 1 year: 2017 ident: 10.1016/j.bspc.2020.102054_bib0210 article-title: 2. Classification and diagnosis of diabetes publication-title: Diabetes Care doi: 10.2337/dc17-S005 – volume: 47 start-page: 1017 issue: 4 year: 2017 ident: 10.1016/j.bspc.2020.102054_bib0160 article-title: Stacked convolutional denoising auto-encoders for feature representation publication-title: IEEE Trans. Cybern. doi: 10.1109/TCYB.2016.2536638 – volume: 32 start-page: 649 issue: 6 year: 2011 ident: 10.1016/j.bspc.2020.102054_bib0010 article-title: Dynamic estimation of cardiac repolarization characteristics during hypoglycemia in healthy and diabetic subjects publication-title: Physiol. Meas. doi: 10.1088/0967-3334/32/6/003 – start-page: 315 year: 2011 ident: 10.1016/j.bspc.2020.102054_bib0225 article-title: Deep sparse rectifier neural networks publication-title: Proceedings of the Fourteenth International Conference on Artificial Intelligence and Statistics – volume: 20 issue: S2 year: 2018 ident: 10.1016/j.bspc.2020.102054_bib0005 article-title: Hypoglycemia: new definitions and regulatory implications publication-title: Diabetes Technol. Ther. doi: 10.1089/dia.2018.0113 – start-page: 7 year: 2018 ident: 10.1016/j.bspc.2020.102054_bib0140 article-title: Arrhythmia detection from 2-lead ECG using convolutional denoising autoencoders – volume: 37 start-page: 499 issue: 8 year: 2014 ident: 10.1016/j.bspc.2020.102054_bib0055 article-title: Hypoglycemia from a cardiologist's perspective: cardiovascular effects of hypoglycemia publication-title: Clin. Cardiol. doi: 10.1002/clc.22288 – volume: 313 start-page: 504 issue: 5786 year: 2006 ident: 10.1016/j.bspc.2020.102054_bib0145 article-title: Reducing the dimensionality of data with neural networks publication-title: Science doi: 10.1126/science.1127647 – start-page: 384 year: 2009 ident: 10.1016/j.bspc.2020.102054_bib0230 article-title: Learning a parametric embedding by preserving local structure publication-title: Artificial Intelligence and Statistics – volume: 55 start-page: 177 issue: 3 year: 2012 ident: 10.1016/j.bspc.2020.102054_bib0090 article-title: Natural occurrence of nocturnal hypoglycemia detection using hybrid particle swarm optimized fuzzy reasoning model publication-title: Artif. Intell. Med. doi: 10.1016/j.artmed.2012.04.003 – volume: 388 start-page: 2254 issue: 10057 year: 2016 ident: 10.1016/j.bspc.2020.102054_bib0185 article-title: Novel glucose-sensing technology and hypoglycaemia in type 1 diabetes: a multicentre, non-masked, randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(16)31535-5 – volume: 55 start-page: 246 issue: 3 year: 2003 ident: 10.1016/j.bspc.2020.102054_bib0025 article-title: Comparative effect of human soluble insulin and insulin aspart upon hypoglycaemia-induced alterations in cardiac repolarization publication-title: Br. J. Clin. Pharmacol. doi: 10.1046/j.1365-2125.2003.01726.x – volume: 10 start-page: 1 issue: 1 year: 2020 ident: 10.1016/j.bspc.2020.102054_bib0100 article-title: Precision medicine and artificial intelligence: a pilot study on deep learning for hypoglycemic events detection based on ECG publication-title: Sci. Rep. doi: 10.1038/s41598-019-56927-5 – start-page: 52 year: 2011 ident: 10.1016/j.bspc.2020.102054_bib0165 article-title: Stacked convolutional auto-encoders for hierarchical feature extraction – volume: 35 start-page: 125 issue: 1 year: 2012 ident: 10.1016/j.bspc.2020.102054_bib0040 article-title: QTc interval prolongation is independently associated with severe hypoglycemic attacks in type 1 diabetes from the EURODIAB IDDM complications study publication-title: Diabetes Care doi: 10.2337/dc11-1739 – start-page: 1238 year: 2014 ident: 10.1016/j.bspc.2020.102054_bib0085 article-title: Non-invasive detection of hypoglycemic episodes in Type 1 diabetes using intelligent hybrid rough neural system publication-title: 2014 IEEE Congress on Evolutionary Computation (CEC) doi: 10.1109/CEC.2014.6900229 – volume: 64 start-page: 2196 issue: 9 year: 2017 ident: 10.1016/j.bspc.2020.102054_bib0135 article-title: Semi-supervised stacked label consistent autoencoder for reconstruction and analysis of biomedical signals publication-title: IEEE Trans. Biomed. Eng. doi: 10.1109/TBME.2016.2631620 – start-page: 227 year: 1990 ident: 10.1016/j.bspc.2020.102054_bib0175 article-title: Probabilistic interpretation of feedforward classification network outputs, with relationships to statistical pattern recognition – start-page: 19 year: 2004 ident: 10.1016/j.bspc.2020.102054_bib0095 article-title: The normal ECG and its (normal) variants – volume: 9 start-page: 2579 year: 2008 ident: 10.1016/j.bspc.2020.102054_bib0180 article-title: Visualizing data using t-SNE publication-title: J. Mach. Learn. Res. – volume: 21 start-page: 543 issue: 2 year: 2017 ident: 10.1016/j.bspc.2020.102054_bib0075 article-title: Hypoglycemia detection: multiple regression-based combinational neural logic approach publication-title: Soft Comput. doi: 10.1007/s00500-015-1809-z – volume: PP start-page: 1 issue: 99 year: 2017 ident: 10.1016/j.bspc.2020.102054_bib0120 article-title: Deep convolutional neural networks and learning ECG features for screening paroxysmal atrial fibrillation patients publication-title: IEEE Trans. Syst. Man Cybern.: Systems – volume: 51 start-page: 426 issue: 3 year: 2008 ident: 10.1016/j.bspc.2020.102054_bib0030 article-title: Effects of controlled hypoglycaemia on cardiac repolarisation in patients with type 1 diabetes publication-title: Diabetologia doi: 10.1007/s00125-007-0902-y – volume: 26 start-page: 1485 issue: 5 year: 2003 ident: 10.1016/j.bspc.2020.102054_bib0060 article-title: Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring publication-title: Diabetes Care doi: 10.2337/diacare.26.5.1485 – start-page: 3503 year: 2016 ident: 10.1016/j.bspc.2020.102054_bib0070 article-title: Deep learning framework for detection of hypoglycemic episodes in children with type 1 diabetes publication-title: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2016 – volume: 35 start-page: 1798 issue: 8 year: 2013 ident: 10.1016/j.bspc.2020.102054_bib0125 article-title: Representation learning: a review and new perspectives publication-title: IEEE Trans. Pattern Anal. Mach. Intell. doi: 10.1109/TPAMI.2013.50 – volume: 6 start-page: 16529 year: 2018 ident: 10.1016/j.bspc.2020.102054_bib0130 article-title: An automatic cardiac arrhythmia classification system with wearable electrocardiogram publication-title: IEEE Access doi: 10.1109/ACCESS.2018.2807700 – volume: 79 start-page: 493 issue: 5 year: 1998 ident: 10.1016/j.bspc.2020.102054_bib0205 article-title: Circadian rhythm of the signal averaged electrocardiogram and its relation to heart rate variability in healthy subjects publication-title: Heart doi: 10.1136/hrt.79.5.493 – year: 2015 ident: 10.1016/j.bspc.2020.102054_bib0220 article-title: Adam: a method for stochastic optimization publication-title: Proceedings of the 3rd International Conference on Learning Representations – volume: 21 start-page: 295 issue: 2 year: 2000 ident: 10.1016/j.bspc.2020.102054_bib0020 article-title: Measurement of high resolution ECG QT interval during controlled euglycaemia and hypoglycaemia publication-title: Physiol. Meas. doi: 10.1088/0967-3334/21/2/309 – start-page: 651 year: 2017 ident: 10.1016/j.bspc.2020.102054_bib0170 article-title: Creation of a deep convolutional auto-encoder in Caffe publication-title: 2017 9th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems: Technology and Applications (IDAACS), vol. 2 – volume: 25 start-page: 65 issue: 1 year: 2019 ident: 10.1016/j.bspc.2020.102054_bib0105 article-title: Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network publication-title: Nat. Med. doi: 10.1038/s41591-018-0268-3 – volume: 11 start-page: 3371 year: 2010 ident: 10.1016/j.bspc.2020.102054_bib0150 article-title: Stacked denoising autoencoders: learning useful representations in a deep network with a local denoising criterion publication-title: J. Mach. Learn. Res. – start-page: 1096 year: 2008 ident: 10.1016/j.bspc.2020.102054_bib0155 article-title: Extracting and composing robust features with denoising autoencoders – volume: 47 start-page: 312 issue: 2 year: 2004 ident: 10.1016/j.bspc.2020.102054_bib0045 article-title: Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with type 1 diabetes publication-title: Diabetologia doi: 10.1007/s00125-003-1292-4 |
| SSID | ssj0048714 |
| Score | 2.345205 |
| Snippet | Hypoglycemia is a condition caused by low blood glucose levels, mainly affecting people with diabetes. Low levels of blood glucose can be dangerous, causing... |
| SourceID | crossref elsevier |
| SourceType | Enrichment Source Index Database Publisher |
| StartPage | 102054 |
| SubjectTerms | Convolutional denoising autoencoder Convolutional neural networks Nocturnal hypoglycemia |
| Title | Nocturnal low glucose detection in healthy elderly from one-lead ECG using convolutional denoising autoencoders |
| URI | https://dx.doi.org/10.1016/j.bspc.2020.102054 |
| Volume | 62 |
| WOSCitedRecordID | wos000575379300005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1746-8108 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0048714 issn: 1746-8094 databaseCode: AIEXJ dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaWlgMcEE-1FJAP3KKgZOO8jtVqKa3Qqoci7S2yHQdSRclqm13a_8MP7Uz8aFqgogcu0cobe62dT-MZ-5vPhHysmEAdqtCPUQ-RRRn3OZeBr_IgLiGBiFRaDpdNpItFtlzmp5PJL1sLs23Sts0uL_PVfzU1tIGxsXT2AeZ2g0IDfAajwxPMDs9_Mvyiw1MBDDKb7qdnKeml6pW0xEZd_HjlKbyiu7nSNSZdq_wGLO7NZ0fexhTjtlszVzzLUW1XD-1803cogFka-rw7FR5q-XWhZf0d-6x0HYKthDTEeOePUQlCaPY-kvfdEnGEW0naIc66tajbG0c5yIGajfYxj_gUUPJDM3-_Ko4yDOMNDcheLWPL-uCUoUayvvvYOmnjsrWXhaAo0NLTvy0Aei_i_JO4WKFA5XTQpjAv31bbvrMKOm6ipb2dFzhGgWMUeoxHZHeaxjn4zt3D4_nyxK74kPMNGvJu4qY4S_MI787kzwHQKKg5e06emWyEHmoUvSAT1b4kT0cala9I5_BEAU_U4Ik6PNG6pQZP1OCJIp6oxRMFPNEBT_QWnqjDEx3j6TX59nl-Nvvim1s6fBkFQe-rhKsIMnmZKRYoUbFQqTCKpjKJZS5lFUvIECCNrcJYQAMXJYMYM4xUzCH3hW_fkJ0WprRHqBRcyKQqM5EoJiG1TyTLkzLNKz5lCZf7JLR_XSGNhD3epNIUfzfaPvFcn5UWcLn37dhapDAhqA4tCwDYPf3ePuhXDsiTG-C_Izv9eqPek8dy29cX6w8GXddyw63N |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nocturnal+low+glucose+detection+in+healthy+elderly+from+one-lead+ECG+using+convolutional+denoising+autoencoders&rft.jtitle=Biomedical+signal+processing+and+control&rft.au=Porumb%2C+Mihaela&rft.au=Griffen%2C+Corbin&rft.au=Hattersley%2C+John&rft.au=Pecchia%2C+Leandro&rft.date=2020-09-01&rft.issn=1746-8094&rft.volume=62&rft.spage=102054&rft_id=info:doi/10.1016%2Fj.bspc.2020.102054&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bspc_2020_102054 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1746-8094&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1746-8094&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1746-8094&client=summon |