Sporadic Creutzfeldt-Jakob Disease: Finding the Needle in the Haystack

Sporadic Creutzfeldt-Jakob disease (SCJD) is a rare neurodegenerative disease with a very low prevalence. The aetiology is theorised to be genetic. Modern laboratory techniques, such as the real-time quaking-induced conversion (RT-QuIC) assay, have allowed us to diagnose CJD with greater sensitivity...

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Vydáno v:Curēus (Palo Alto, CA) Ročník 16; číslo 7; s. e64548
Hlavní autoři: Ghazanfar, Auns, Pittford, Alexandra, Fernando, Kryshani
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Springer Nature B.V 15.07.2024
Cureus
Témata:
Antibodies
Biological & chemical weapons
Brain research
Creutzfeldt-Jakob disease
Dementia
Fatalities
Glycoproteins
Iatrogenesis
Infectious Disease
Internal Medicine
Kinases
Magnetic resonance imaging
Memory
Neurology
Proteins
Surveillance
United Kingdom > UK
creutzfeld-jakob disease
neuro-psychiatric
personality disrders
gait disturbance
memory issues
ISSN:2168-8184, 2168-8184
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Shrnutí:Sporadic Creutzfeldt-Jakob disease (SCJD) is a rare neurodegenerative disease with a very low prevalence. The aetiology is theorised to be genetic. Modern laboratory techniques, such as the real-time quaking-induced conversion (RT-QuIC) assay, have allowed us to diagnose CJD with greater sensitivity and specificity. Previously, the diagnosis rested primarily on a post-mortem brain biopsy. Although advancements in laboratory techniques have allowed earlier diagnosis of CJD, the treatment is still supportive. Research is still ongoing for a curative treatment, but so far, the fatality rate remains at 100%. Early vague symptoms of CJD delay the diagnosis further, as multiple pathologies need to be ruled out before consideration of the diagnosis of CJD. This case report describes a similar case of sporadic CJD diagnosed in an otherwise fit and well patient.
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ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.64548