Aminopeptidase N as a potential drug target

Aminopeptidase N (APN) is a broad specificity zinc metallopeptidase with many functions that do not always depend on its enzymatic activity. Among others, it is involved in tumor angiogenesis and metastasizing and also serves as a cellular receptor of some coronaviruses. Some APN inhibitors, such as...

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Published in:EUROPEAN PHARMACEUTICAL JOURNAL Vol. 70; no. 2; pp. 52 - 53
Main Authors: Farsa, Oldřich, Ballayová, Veronika, Žáčková, Radka, Zubáč, Peter
Format: Journal Article
Language:English
Published: Warsaw Sciendo 01.12.2023
De Gruyter Brill Sp. z o.o., Paradigm Publishing Services
Subjects:
aminopeptidase N
anti-infectious activity
antitumor activity
Cancer therapies
Coronaviruses
Drug dosages
inhibitors
Leukemia
Medical research
Tumors
ISSN:2453-6725, 2453-6725
Online Access:Get full text
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Summary:Aminopeptidase N (APN) is a broad specificity zinc metallopeptidase with many functions that do not always depend on its enzymatic activity. Among others, it is involved in tumor angiogenesis and metastasizing and also serves as a cellular receptor of some coronaviruses. Some APN inhibitors, such as bestatin or tosedostat, were used or tested as anticancer drugs in the past. Within the past two decades, we have prepared several series of potential APN inhibitors. Some of them reached interesting values of inhibitory activity and were also successfully tested for antiproliferation activity in cancer cell lines. We also performed some QSAR studies with APN inhibitors prepared by us and other authors.
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ISSN:2453-6725
2453-6725
DOI:10.2478/afpuc-2024-0002