The cytotoxic activity of pine needles ethanolic extract of Pinus merkusii on HeLa cell lines

Several efforts have been made to discover new anticancer agents based on natural ingredients. Meanwhile, previous studies have shown that different Pine genus species exhibit cytotoxic activity against various types of cancer cells. This plant is rich in phenolic compounds, especially procyanidins,...

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Bibliographic Details
Published in:BIO web of conferences Vol. 33; p. 3001
Main Authors: Proboningrat, Annise, Fadholly, Amaq, Agus Sudjarwo, Sri, Abdul Rantam, Fedik, Budianto Achmad, Agung
Format: Journal Article Conference Proceeding
Language:English
Published: Les Ulis EDP Sciences 01.01.2021
Subjects:
Anticancer properties
antineoplastic agents
Antitumor agents
Cancer
Cytotoxicity
Flavonoids
human cell lines
inhibitory concentration 50
neoplasm cells
Phenolic acids
Phenols
Pine needles
Pine trees
Pinus merkusii
Plant cells
Procyanidins
Toxicity
Tumor cell lines
ISSN:2117-4458, 2273-1709, 2117-4458
Online Access:Get full text
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Summary:Several efforts have been made to discover new anticancer agents based on natural ingredients. Meanwhile, previous studies have shown that different Pine genus species exhibit cytotoxic activity against various types of cancer cells. This plant is rich in phenolic compounds, especially procyanidins, flavonoids, and phenolic acids. Therefore, this study aims to investigate the in vitro cytotoxicity of Pinus merkusii needles extract on HeLa cancer cell lines. The cytotoxicity assessment was measured using MTT assay and expressed as IC 50 value. The results showed that the ethanolic extract poses a dose and time-dependent cytotoxic activity with an IC 50 value of 542.5 µg/ml at 48 hours of incubation. Based on this result, Pinus merkusii needles’ ethanolic extract has the potential of a novel candidate for an anticancer agent.
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ISSN:2117-4458
2273-1709
2117-4458
DOI:10.1051/bioconf/20213303001