The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2

This laboratory has shown that MT-3 expression determines the choice between apoptotic or necrotic cell death in Cd(+2)-exposed human proximal tubule cells. Human proximal tubule cells that express MT-3 undergo necrosis when exposed to Cd(+2), while cells that have no basal expression of MT-3 underg...

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Bibliographic Details
Published in:	Toxicological sciences Vol. 90; no. 2; p. 369
Main Authors:	Somji, Seema, Garrett, Scott H, Sens, Mary Ann, Sens, Donald A
Format:	Journal Article
Language:	English
Published:	United States 01.04.2006
Subjects:	Alzheimer Disease - metabolism Apoptosis Cadmium - toxicity Cell Death - drug effects Cell Line Cell Survival - drug effects Humans Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - pathology L-Lactate Dehydrogenase - metabolism Mutagenesis, Site-Directed Necrosis Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism RNA, Messenger - metabolism
ISSN:	1096-6080
Online Access:	Get more information
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