Structure-function connectomics reveals aberrant left hemispheric developmental trajectory in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by structural and functional brain differences relative to typically developing individuals. Although previous work has identified abnormalities in rich-club (RC) organization and left-right asymmetry in ASD, the developm...
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| Vydáno v: | Cerebral cortex (New York, N.Y. 1991) Ročník 35; číslo 6 |
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| Hlavní autoři: | , , , , , |
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| Jazyk: | angličtina |
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04.06.2025
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| ISSN: | 1460-2199, 1460-2199 |
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| Abstract | Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by structural and functional brain differences relative to typically developing individuals. Although previous work has identified abnormalities in rich-club (RC) organization and left-right asymmetry in ASD, the developmental trajectory of these anomalies remains unclear. In this study, we examined how age influences structure-function coupling and structural proportions in RC networks using data from 140 participants (aged 5-26 years) drawn from ABIDE II. Our findings revealed significant, age-related differences in the left hemisphere of ASD participants compared to controls, with the RC network predominantly localized in this region. Furthermore, an interaction effect in local RC organization-though not in global RC or feeder connections-was observed between diagnostic groups and brain lateralization. Notably, rightward lateralization in local RC networks increased with age in ASD individuals, whereas it decreased with age in controls. These results underscore an atypical, age-dependent pattern of hemispheric asymmetry in ASD and offer new insights into abnormal neurodevelopmental trajectories within RC organization. |
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| AbstractList | Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by structural and functional brain differences relative to typically developing individuals. Although previous work has identified abnormalities in rich-club (RC) organization and left-right asymmetry in ASD, the developmental trajectory of these anomalies remains unclear. In this study, we examined how age influences structure-function coupling and structural proportions in RC networks using data from 140 participants (aged 5-26 years) drawn from ABIDE II. Our findings revealed significant, age-related differences in the left hemisphere of ASD participants compared to controls, with the RC network predominantly localized in this region. Furthermore, an interaction effect in local RC organization-though not in global RC or feeder connections-was observed between diagnostic groups and brain lateralization. Notably, rightward lateralization in local RC networks increased with age in ASD individuals, whereas it decreased with age in controls. These results underscore an atypical, age-dependent pattern of hemispheric asymmetry in ASD and offer new insights into abnormal neurodevelopmental trajectories within RC organization.Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by structural and functional brain differences relative to typically developing individuals. Although previous work has identified abnormalities in rich-club (RC) organization and left-right asymmetry in ASD, the developmental trajectory of these anomalies remains unclear. In this study, we examined how age influences structure-function coupling and structural proportions in RC networks using data from 140 participants (aged 5-26 years) drawn from ABIDE II. Our findings revealed significant, age-related differences in the left hemisphere of ASD participants compared to controls, with the RC network predominantly localized in this region. Furthermore, an interaction effect in local RC organization-though not in global RC or feeder connections-was observed between diagnostic groups and brain lateralization. Notably, rightward lateralization in local RC networks increased with age in ASD individuals, whereas it decreased with age in controls. These results underscore an atypical, age-dependent pattern of hemispheric asymmetry in ASD and offer new insights into abnormal neurodevelopmental trajectories within RC organization. Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by structural and functional brain differences relative to typically developing individuals. Although previous work has identified abnormalities in rich-club (RC) organization and left-right asymmetry in ASD, the developmental trajectory of these anomalies remains unclear. In this study, we examined how age influences structure-function coupling and structural proportions in RC networks using data from 140 participants (aged 5-26 years) drawn from ABIDE II. Our findings revealed significant, age-related differences in the left hemisphere of ASD participants compared to controls, with the RC network predominantly localized in this region. Furthermore, an interaction effect in local RC organization-though not in global RC or feeder connections-was observed between diagnostic groups and brain lateralization. Notably, rightward lateralization in local RC networks increased with age in ASD individuals, whereas it decreased with age in controls. These results underscore an atypical, age-dependent pattern of hemispheric asymmetry in ASD and offer new insights into abnormal neurodevelopmental trajectories within RC organization. |
| Author | Zhao, Shuo Niu, Yan Luo, Qin Yang, Lan Li, Zhifeng Wang, Bin |
| Author_xml | – sequence: 1 givenname: Zhifeng surname: Li fullname: Li, Zhifeng organization: College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China – sequence: 2 givenname: Bin surname: Wang fullname: Wang, Bin organization: College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China – sequence: 3 givenname: Lan surname: Yang fullname: Yang, Lan organization: College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China – sequence: 4 givenname: Yan surname: Niu fullname: Niu, Yan organization: College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China – sequence: 5 givenname: Qin surname: Luo fullname: Luo, Qin organization: School of Psychology, Shenzhen University, 3688 Nanhai Avenue, Nanshan District, Shenzhen, Guangdong 518060, China – sequence: 6 givenname: Shuo surname: Zhao fullname: Zhao, Shuo organization: Shenzhen Key Lab Affect & Social Neuroscience, Shenzhen University, 3688 Nanhai Avenue, Nanshan District, Shenzhen, Guangdong 518060, China |
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| Keywords | developmental trajectories hemispheric asymmetry rich club organization autism spectrum disorder structure–function coupling |
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| Title | Structure-function connectomics reveals aberrant left hemispheric developmental trajectory in autism spectrum disorder |
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