Optimization protocols and improved strategies for metal-organic frameworks for immobilizing enzymes: Current development and future challenges

[Display omitted] •Enzyme@MOF composites are still at an early stage of development.•Enzyme@MOF composites are a versatile host platform for the effective enzymes immobilization systems.•Different approaches and process optimization of preparing enzyme@MOF composites are evaluated.•There will be gre...

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Bibliographic Details
Published in:Coordination chemistry reviews Vol. 370; pp. 22 - 41
Main Authors: Cui, Jiandong, Ren, Sizhu, Sun, Baoting, Jia, Shiru
Format: Journal Article
Language:English
Published: Elsevier B.V 01.09.2018
Subjects:
Enzyme immobilization
Improved strategies
Metal-organic frameworks
Process optimization
Improved strategies
Process optimization
Enzyme immobilization
Metal-organic frameworks
ISSN:0010-8545, 1873-3840
Online Access:Get full text
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Summary:[Display omitted] •Enzyme@MOF composites are still at an early stage of development.•Enzyme@MOF composites are a versatile host platform for the effective enzymes immobilization systems.•Different approaches and process optimization of preparing enzyme@MOF composites are evaluated.•There will be great demand on Enzyme@MOF composites with diverse functionality. Metal-organic frameworks (MOFs) are a type of porous material that have tunable porosity, desirable functionality, extremely high surface area, and chemical/thermal stability. MOFs consist of metal containing nodes and organic ligands linked through coordination bonds. Owing to the unique properties of MOFs, there is considerable interest in using them as a potential matrix for enzyme immobilization. Recent studies have focused on developing enzyme-MOF composites with potential applications. Many MOF-enzyme composites exhibit excellent catalytic performance, far outperforming free enzymes in many aspects. This review summarizes recent developments in enzyme-MOF composites with special emphasis on novel synthesizing strategies, process optimization, and improvement of catalytic performance of the enzyme-MOF composites over free enzymes.
ISSN:0010-8545
1873-3840
DOI:10.1016/j.ccr.2018.05.004