Thrombocytopenia, neutropenia, ulcerative dermatitis and haemarthrosis in a neonatal foal

Summary A 3‐day‐old Standardbred filly, born from a multiparous mare, was presented for assessment of limb swellings and reduced appetite. Physical examination revealed tachycardia, multifocal petechial and ecchymotic haemorrhages, stiff gait, polysynovial effusion, as well as erosions, multifocal c...

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Published in:Equine veterinary education Vol. 30; no. 12; pp. 647 - 653
Main Authors: Preez, S., Hughes, K. J.
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc 01.12.2018
Subjects:
Anemia
Appetite loss
Blood culture
Blood transfusion
coagulopathy
Corticosteroids
Dermatitis
Drugs
Effusion
Erythema
Gait
Hemorrhage
horse
immune‐mediated
Immunity
Immunity (passive)
Immunosuppressive agents
Neonates
Neutropenia
neutrophil
platelet
Skin
Tachycardia
Thrombocytopenia
ISSN:0957-7734, 2042-3292
Online Access:Get full text
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Summary:Summary A 3‐day‐old Standardbred filly, born from a multiparous mare, was presented for assessment of limb swellings and reduced appetite. Physical examination revealed tachycardia, multifocal petechial and ecchymotic haemorrhages, stiff gait, polysynovial effusion, as well as erosions, multifocal crusting and erythema of the skin. Laboratory examinations revealed adequate transfer of passive immunity, marked thrombocytopenia, moderate neutropenia and anaemia. Aerobic bacterial blood culture was negative. Sanguineous fluid, consistent with haemarthrosis, was obtained by synoviocentesis. The foal was successfully managed with the administration of blood transfusions, an immunosuppressive regimen of corticosteroid medication, systemic antimicrobial medication and supportive care and recovered uneventfully. This report describes a neonatal foal with marked thrombocytopenia and signs of coagulopathy, neutropenia and ulcerative dermatitis consistent with a previously described syndrome. This case emphasises that alloimmune disease should be considered in neonatal foals with haemostatic disturbances or unexplained cytopenia.
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ISSN:0957-7734
2042-3292
DOI:10.1111/eve.12737