Multidrug-resistant and extensively drug-resistant tuberculosis: a review

The spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) is a major medical and public health concern for the world. These two forms of highly drug-resistant TB threaten to make TB into an untreatable and highly fatal disease, particularly in resource-poor c...

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Vydáno v:	Current opinion in infectious diseases Ročník 21; číslo 6; s. 587
Hlavní autoři:	Chan, Edward D, Iseman, Michael D
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.12.2008
Témata:	Antitubercular Agents - therapeutic use Communicable Disease Control - methods Extensively Drug-Resistant Tuberculosis - diagnosis Extensively Drug-Resistant Tuberculosis - epidemiology Extensively Drug-Resistant Tuberculosis - mortality Extensively Drug-Resistant Tuberculosis - prevention & control Genes, Bacterial Humans Risk Factors Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - mortality Tuberculosis, Multidrug-Resistant - prevention & control
ISSN:	1473-6527, 1473-6527
On-line přístup:	Zjistit podrobnosti o přístupu
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Popis
Shrnutí:	The spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) is a major medical and public health concern for the world. These two forms of highly drug-resistant TB threaten to make TB into an untreatable and highly fatal disease, particularly in resource-poor countries with a high prevalence of AIDS. The focus of this review is to highlight the current extent of the problem. There is a great variability in clinical outcomes for MDR-TB, in part due to differences in the definitions of outcome measures and retrospective nature of the studies. Outcomes for XDR-TB are uniformly worse than those for MDR-TB. A multifaceted approach is needed to prevent a more widespread epidemic of MDR-TB and XDR-TB. Rapid diagnostic assays to detect highly drug-resistant TB are essential in preventing delays in treatment of MDR-TB and XDR-TB and curbing their spread. Development of new drugs to effectively treat all forms of TB in a shorter period of time is urgently needed.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1473-6527 1473-6527
DOI:	10.1097/QCO.0b013e328319bce6