Multidrug-resistant and extensively drug-resistant tuberculosis: a review

The spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) is a major medical and public health concern for the world. These two forms of highly drug-resistant TB threaten to make TB into an untreatable and highly fatal disease, particularly in resource-poor c...

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Vydané v:Current opinion in infectious diseases Ročník 21; číslo 6; s. 587
Hlavní autori: Chan, Edward D, Iseman, Michael D
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.12.2008
Predmet:
Antitubercular Agents - therapeutic use
Communicable Disease Control - methods
Extensively Drug-Resistant Tuberculosis - diagnosis
Extensively Drug-Resistant Tuberculosis - epidemiology
Extensively Drug-Resistant Tuberculosis - mortality
Extensively Drug-Resistant Tuberculosis - prevention & control
Genes, Bacterial
Humans
Risk Factors
Tuberculosis, Multidrug-Resistant - diagnosis
Tuberculosis, Multidrug-Resistant - epidemiology
Tuberculosis, Multidrug-Resistant - mortality
Tuberculosis, Multidrug-Resistant - prevention & control
ISSN:1473-6527, 1473-6527
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Popis
Shrnutí:The spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) is a major medical and public health concern for the world. These two forms of highly drug-resistant TB threaten to make TB into an untreatable and highly fatal disease, particularly in resource-poor countries with a high prevalence of AIDS. The focus of this review is to highlight the current extent of the problem. There is a great variability in clinical outcomes for MDR-TB, in part due to differences in the definitions of outcome measures and retrospective nature of the studies. Outcomes for XDR-TB are uniformly worse than those for MDR-TB. A multifaceted approach is needed to prevent a more widespread epidemic of MDR-TB and XDR-TB. Rapid diagnostic assays to detect highly drug-resistant TB are essential in preventing delays in treatment of MDR-TB and XDR-TB and curbing their spread. Development of new drugs to effectively treat all forms of TB in a shorter period of time is urgently needed.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1473-6527
1473-6527
DOI:10.1097/QCO.0b013e328319bce6