Impact of physiologically relevant temperatures on dermal absorption of active substances - an ex-vivo study in human skin

Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorptio...

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Veröffentlicht in:	Toxicology in vitro Jg. 68; S. 104954
Hauptverfasser:	Kilo, S., Wick, J., Mini Vijayan, S., Göen, T., Horch, R.E., Ludolph, I., Drexler, H.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.10.2020 Elsevier Science Ltd
Schlagworte:	Absorption Anisole Anisoles - metabolism Blood circulation Dermal absorption Diffusion cell Diffusion cells Dioxanes - metabolism Environmental conditions Ethanol Ethanol - metabolism Exposure Humans Influence of temperature Lipids Lipophilic Modulation Penetration Perfusion Skin Skin - metabolism Skin Absorption Skin temperature Temperature Temperature dependence Thermoregulation Transdermal penetration LOD SC CAS Log P SEM Transdermal penetration Influence of temperature Dermal absorption Diffusion cell
ISSN:	0887-2333, 1879-3177, 1879-3177
Online-Zugang:	Volltext
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