Impact of physiologically relevant temperatures on dermal absorption of active substances - an ex-vivo study in human skin
Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorptio...
Saved in:
| Published in: | Toxicology in vitro Vol. 68; p. 104954 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
01.10.2020
Elsevier Science Ltd |
| Subjects: | |
| ISSN: | 0887-2333, 1879-3177, 1879-3177 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorption of the model lipophilic compound (anisole) and the model hydrophilic compounds (1,4-dioxane, ethanol) through human skin was investigated at three dermal temperatures (25, 32 and 39 °C) in an ex-vivo diffusion cell model. The substances were applied to the skin and transdermal penetration was monitored. All substances showed temperature dependent variations in their penetration behavior (3 h: 25–39 °C: 202–275% increase in cumulative, transdermally penetrated amounts). The relative differences in absorption in relation to temperature were greatest within 45 min after exposure (25–39 °C: 347–653% rise in cumulated penetration), although absolute amounts absorbed were small (45 min vs. 3 h: 4.5–14.5%). Regardless of blood circulation, skin temperature significantly influences the amount and kinetics of dermal absorption. Substance-dependent, temperature-related changes of the lipid layer order or the porous pathway may facilitate penetration. The early-stage modulation of transdermal penetration indicates transappendageal absorption, which may be relevant for short-term exposures. For both, toxicological evaluation and perfusion cell studies, it is important to consider the thermal influence on absorption or to perform the latter at a standardized temperature (32±1 °C).
•Regardless the effect on blood flow, skin temperature significantly influences absorption.•The impact of temperature on dermal absorption is substrate-specific.•The penetration pathways through skin are influenced differently by temperature.•The influence of the temperature varies over the time course of the absorption. |
|---|---|
| AbstractList | Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorption of the model lipophilic compound (anisole) and the model hydrophilic compounds (1,4-dioxane, ethanol) through human skin was investigated at three dermal temperatures (25, 32 and 39 °C) in an ex-vivo diffusion cell model. The substances were applied to the skin and transdermal penetration was monitored. All substances showed temperature dependent variations in their penetration behavior (3 h: 25–39 °C: 202–275% increase in cumulative, transdermally penetrated amounts). The relative differences in absorption in relation to temperature were greatest within 45 min after exposure (25–39 °C: 347–653% rise in cumulated penetration), although absolute amounts absorbed were small (45 min vs. 3 h: 4.5–14.5%). Regardless of blood circulation, skin temperature significantly influences the amount and kinetics of dermal absorption. Substance-dependent, temperature-related changes of the lipid layer order or the porous pathway may facilitate penetration. The early-stage modulation of transdermal penetration indicates transappendageal absorption, which may be relevant for short-term exposures. For both, toxicological evaluation and perfusion cell studies, it is important to consider the thermal influence on absorption or to perform the latter at a standardized temperature (32±1 °C).
•Regardless the effect on blood flow, skin temperature significantly influences absorption.•The impact of temperature on dermal absorption is substrate-specific.•The penetration pathways through skin are influenced differently by temperature.•The influence of the temperature varies over the time course of the absorption. Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorption of the model lipophilic compound (anisole) and the model hydrophilic compounds (1,4-dioxane, ethanol) through human skin was investigated at three dermal temperatures (25, 32 and 39 °C) in an ex-vivo diffusion cell model. The substances were applied to the skin and transdermal penetration was monitored. All substances showed temperature dependent variations in their penetration behavior (3 h: 25-39 °C: 202-275% increase in cumulative, transdermally penetrated amounts). The relative differences in absorption in relation to temperature were greatest within 45 min after exposure (25-39 °C: 347-653% rise in cumulated penetration), although absolute amounts absorbed were small (45 min vs. 3 h: 4.5-14.5%). Regardless of blood circulation, skin temperature significantly influences the amount and kinetics of dermal absorption. Substance-dependent, temperature-related changes of the lipid layer order or the porous pathway may facilitate penetration. The early-stage modulation of transdermal penetration indicates transappendageal absorption, which may be relevant for short-term exposures. For both, toxicological evaluation and perfusion cell studies, it is important to consider the thermal influence on absorption or to perform the latter at a standardized temperature (32±1 °C). Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorption of the model lipophilic compound (anisole) and the model hydrophilic compounds (1,4-dioxane, ethanol) through human skin was investigated at three dermal temperatures (25, 32 and 39 °C) in an ex-vivo diffusion cell model. The substances were applied to the skin and transdermal penetration was monitored. All substances showed temperature dependent variations in their penetration behavior (3 h: 25–39 °C: 202–275% increase in cumulative, transdermally penetrated amounts). The relative differences in absorption in relation to temperature were greatest within 45 min after exposure (25–39 °C: 347–653% rise in cumulated penetration), although absolute amounts absorbed were small (45 min vs. 3 h: 4.5–14.5%). Regardless of blood circulation, skin temperature significantly influences the amount and kinetics of dermal absorption. Substance-dependent, temperature-related changes of the lipid layer order or the porous pathway may facilitate penetration. The early-stage modulation of transdermal penetration indicates transappendageal absorption, which may be relevant for short-term exposures. For both, toxicological evaluation and perfusion cell studies, it is important to consider the thermal influence on absorption or to perform the latter at a standardized temperature (32±1 °C). Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorption of the model lipophilic compound (anisole) and the model hydrophilic compounds (1,4-dioxane, ethanol) through human skin was investigated at three dermal temperatures (25, 32 and 39 °C) in an ex-vivo diffusion cell model. The substances were applied to the skin and transdermal penetration was monitored. All substances showed temperature dependent variations in their penetration behavior (3 h: 25-39 °C: 202-275% increase in cumulative, transdermally penetrated amounts). The relative differences in absorption in relation to temperature were greatest within 45 min after exposure (25-39 °C: 347-653% rise in cumulated penetration), although absolute amounts absorbed were small (45 min vs. 3 h: 4.5-14.5%). Regardless of blood circulation, skin temperature significantly influences the amount and kinetics of dermal absorption. Substance-dependent, temperature-related changes of the lipid layer order or the porous pathway may facilitate penetration. The early-stage modulation of transdermal penetration indicates transappendageal absorption, which may be relevant for short-term exposures. For both, toxicological evaluation and perfusion cell studies, it is important to consider the thermal influence on absorption or to perform the latter at a standardized temperature (32±1 °C).Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges caused by physiological thermoregulation or environmental conditions are largely unknown. The influence of dermal temperature on the absorption of the model lipophilic compound (anisole) and the model hydrophilic compounds (1,4-dioxane, ethanol) through human skin was investigated at three dermal temperatures (25, 32 and 39 °C) in an ex-vivo diffusion cell model. The substances were applied to the skin and transdermal penetration was monitored. All substances showed temperature dependent variations in their penetration behavior (3 h: 25-39 °C: 202-275% increase in cumulative, transdermally penetrated amounts). The relative differences in absorption in relation to temperature were greatest within 45 min after exposure (25-39 °C: 347-653% rise in cumulated penetration), although absolute amounts absorbed were small (45 min vs. 3 h: 4.5-14.5%). Regardless of blood circulation, skin temperature significantly influences the amount and kinetics of dermal absorption. Substance-dependent, temperature-related changes of the lipid layer order or the porous pathway may facilitate penetration. The early-stage modulation of transdermal penetration indicates transappendageal absorption, which may be relevant for short-term exposures. For both, toxicological evaluation and perfusion cell studies, it is important to consider the thermal influence on absorption or to perform the latter at a standardized temperature (32±1 °C). |
| ArticleNumber | 104954 |
| Author | Mini Vijayan, S. Kilo, S. Drexler, H. Horch, R.E. Ludolph, I. Göen, T. Wick, J. |
| Author_xml | – sequence: 1 givenname: S. surname: Kilo fullname: Kilo, S. email: sonja.kilo@fau.de organization: Institute and Out-Patient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany – sequence: 2 givenname: J. surname: Wick fullname: Wick, J. organization: Institute and Out-Patient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany – sequence: 3 givenname: S. surname: Mini Vijayan fullname: Mini Vijayan, S. organization: Institute and Out-Patient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany – sequence: 4 givenname: T. surname: Göen fullname: Göen, T. organization: Institute and Out-Patient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany – sequence: 5 givenname: R.E. surname: Horch fullname: Horch, R.E. organization: Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany – sequence: 6 givenname: I. surname: Ludolph fullname: Ludolph, I. organization: Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany – sequence: 7 givenname: H. surname: Drexler fullname: Drexler, H. organization: Institute and Out-Patient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32738276$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1q3DAURkVISSZpH6CbIugmG0_1Y1syXZWQJoFAN-1ayNJ1o6ktuZJsMn36aphkk0VW4l7OuYjvu0CnPnhA6CMlW0po-2W3zW7dMsIOc9019QnaUCm6ilMhTtGGSCkqxjk_Rxcp7QghjWTkDJ1zJrhkot2gf_fTrE3GYcDz4z65MIbfzuhx3OMII6zaZ5xhmiHqvERIOHhsIU56xLpPIc7ZlU2xyxG3Ak5Ln7L2ppAV1h7DU7W6NeCUF7vHzuPHZSrr9Mf59-jdoMcEH57fS_Tr-83P67vq4cft_fW3h8qwrs2VlH1jGdGt7MGyobO1tQ1roKamNlwwMZhGt4OGXveiMZy3oiOaUaCN6QZD-CW6Ot6dY_i7QMpqcsnAOGoPYUmK1awTQnJaF_TzK3QXlujL7wpVy66hkrJCfXqmln4Cq-boJh336iXVAogjYGJIKcKgjMv6kFSO2o2KEnXoT-1UyUwd-lPH_opJX5kvx99yvh4dKCGuDqJKxkGpwLoIJisb3Bv2f4ZptDQ |
| CitedBy_id | crossref_primary_10_1038_s41597_024_03026_4 crossref_primary_10_1016_j_buildenv_2021_108483 crossref_primary_10_1016_j_yrtph_2020_104752 crossref_primary_10_1016_j_tiv_2020_105055 crossref_primary_10_1016_j_toxlet_2025_05_005 crossref_primary_10_1007_s40005_021_00536_w crossref_primary_10_1208_s12249_024_03033_z crossref_primary_10_3390_ph18060810 crossref_primary_10_1080_10717544_2021_1989088 |
| Cites_doi | 10.1023/A:1010137807610 10.1111/1523-1747.ep12533356 10.1097/00000539-200109000-00023 10.1111/j.1468-2494.2010.00587.x 10.1038/jes.2013.23 10.1111/bph.13059 10.1038/jid.1961.55 10.1111/1523-1747.ep12526137 10.1111/j.1087-0024.2005.10124.x 10.1016/j.xphs.2017.12.011 10.1016/j.saa.2017.07.001 10.1002/jps.24334 10.3109/03639045.2015.1047847 10.1159/000211511 10.1039/c4pp00066h 10.1046/j.0022-202x.2001.01433.x 10.1002/andp.18551700105 10.1371/journal.pone.0205458 10.1002/jps.2600840813 10.1159/000348876 10.1186/1745-6673-3-26 10.1007/BF00377662 10.1159/000092593 10.1016/0887-2333(94)90186-4 10.1016/j.ijpharm.2017.07.031 10.1073/pnas.1608739114 10.1046/j.1365-2133.1998.02166.x 10.1159/000091978 10.1111/j.1600-0781.2006.00201.x 10.1016/j.jconrel.2012.01.042 10.1186/1752-1947-6-220 10.1016/j.jdermsci.2015.07.016 10.1016/j.tiv.2012.11.016 10.1007/BF00375720 10.1046/j.1600-0773.2003.pto930508.x 10.1159/000093117 10.1016/j.clindermatol.2011.08.013 10.1111/j.1365-2133.1975.tb06735.x 10.1038/jid.1967.184 10.1016/j.addr.2012.02.011 10.1152/physrev.1971.51.4.702 10.1002/jat.1505 |
| ContentType | Journal Article |
| Copyright | 2020 Elsevier Ltd Copyright © 2020 Elsevier Ltd. All rights reserved. Copyright Elsevier Science Ltd. Oct 2020 |
| Copyright_xml | – notice: 2020 Elsevier Ltd – notice: Copyright © 2020 Elsevier Ltd. All rights reserved. – notice: Copyright Elsevier Science Ltd. Oct 2020 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TK 7U7 C1K 7X8 |
| DOI | 10.1016/j.tiv.2020.104954 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Toxicology Abstracts Neurosciences Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Toxicology Abstracts MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Public Health Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1879-3177 |
| ExternalDocumentID | 32738276 10_1016_j_tiv_2020_104954 S088723332030504X |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 29Q 4.4 457 4G. 53G 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABFRF ABFYP ABJNI ABLST ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KCYFY KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SDP SES SEW SPCBC SPT SSJ SSP SSZ T5K UNMZH WUQ ZXP ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD CGR CUY CVF ECM EIF NPM 7TK 7U7 AGCQF AGRNS BNPGV C1K SSH 7X8 |
| ID | FETCH-LOGICAL-c296t-88b5d20a68bed2f9d4dd525e41c4c3727fc5a6faebab75c336790a21e15c9fc03 |
| ISSN | 0887-2333 1879-3177 |
| IngestDate | Thu Oct 02 09:41:53 EDT 2025 Tue Jul 15 04:05:43 EDT 2025 Wed Feb 19 02:28:32 EST 2025 Sat Nov 29 07:17:53 EST 2025 Tue Nov 18 21:38:40 EST 2025 Fri Feb 23 02:49:25 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | LOD SC CAS Log P SEM Transdermal penetration Influence of temperature Dermal absorption Diffusion cell |
| Language | English |
| License | Copyright © 2020 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c296t-88b5d20a68bed2f9d4dd525e41c4c3727fc5a6faebab75c336790a21e15c9fc03 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 32738276 |
| PQID | 2448951812 |
| PQPubID | 2047453 |
| ParticipantIDs | proquest_miscellaneous_2429778314 proquest_journals_2448951812 pubmed_primary_32738276 crossref_citationtrail_10_1016_j_tiv_2020_104954 crossref_primary_10_1016_j_tiv_2020_104954 elsevier_sciencedirect_doi_10_1016_j_tiv_2020_104954 |
| PublicationCentury | 2000 |
| PublicationDate | October 2020 2020-10-00 2020-Oct 20201001 |
| PublicationDateYYYYMMDD | 2020-10-01 |
| PublicationDate_xml | – month: 10 year: 2020 text: October 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Oxford |
| PublicationTitle | Toxicology in vitro |
| PublicationTitleAlternate | Toxicol In Vitro |
| PublicationYear | 2020 |
| Publisher | Elsevier Ltd Elsevier Science Ltd |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier Science Ltd |
| References | Cua, Wilhelm, Maibach (bb0045) 1990; 282 Hughes, Fisher, Birnbaum, Hall (bb0105) 1994; 8 Kodiweera, Yang, Bunge (bb0110) 2018; 107 Frölich, Giannotti, Modell (bb0085) 2001; 93 Scheuplein, Blank (bb0220) 1971; 51 (bb0020) 2012 Trommer, Neubert (bb0255) 2006; 19 (accessed 06. Jan. 2020). OECD (bb0160) 2004 Lachenmeier (bb0120) 2008; 3 Le Fur, Reinberg, Lopez, Morizot, Mechkouri, Tschachler (bb0130) 2001; 117 Petersen, Philipsen, Wulf (bb0195) 2014; 13 Pham, Topgaard, Sparr (bb0200) 2017; 114 Teichmann, Otberg, Jacobi, Sterry, Lademann (bb0250) 2006; 19 Arens, Zhang (bb0010) 2006 Spencer, Linamen, Akers, Jones (bb0240) 1975; 93 Sindali, Sherry, Sen, Dheansa (bb0230) 2012; 6 Elias, Cooper, Korc, Brown (bb0060) 1981; 76 GESTIS substance database. German Social Accident Insurance, information system on hazardous substances. Biniek, Kaczvinsky, Matts, Dauskardt (bb0025) 2015; 80 Blazejczyk (bb0035) 1999; 1 Franz (bb0070) 1975; 64 Menon, Elias (bb0145) 1997; 10 Peck, Ghanem, Higuchi (bb0190) 1995; 84 Lee, Lee, Cho, Chung (bb0135) 2006; 22 Smith, Fischer, Blank (bb0235) 1961; 36 Holmgaard, Benfeldt, Sorensen, Nielsen (bb0100) 2013; 26 Frasch, Dotson, Bunge (bb0080) 2014; 24 Göen, Müller, Hoppe (bb0095) 2020; 5 OECD (bb0165) 2004 Vogt, Mandt, Lademann, Schaefer, Blume-Peytavi (bb0270) 2005; 10 Dennerlein, Schneider, Göen, Schaller, Drexler, Korinth (bb0055) 2013; 27 Ngo, O'Malley, Maibach (bb0150) 2010; 30 Tanojo, Bouwstra, Junginger, Boddé (bb0245) 1999; 57 Viljoen, Cowley, du Preez, Gerber, du Plessis (bb0265) 2015; 41 Olsztynska-Janus, Pietruszka, Kielbowicz, Czarnecki (bb0175) 2018; 188 Notman, Anwar (bb0155) 2013; 65 Fick (bb0065) 1855; 170 Larsen, Nielsen, Sorensen, Nielsen (bb0125) 2003; 93 Baranowska-Dutkiewicz (bb0015) 1981; 49 PubChem database (bb0205) Blank, Scheuplein, MacFarlane (bb0030) 1967; 49 Machado, Hadgraft, Lane (bb0140) 2010; 32 Silva, Nunes, Eusebio, Pais, Sousa (bb0225) 2006; 19 Konda, Meier-Davis, Cayme, Shudo, Maibach (bb0115) 2012; 17 Ameen, Michniak-Kohn (bb0005) 2017; 529 van der Maaden, Jiskoot, Bouwstra (bb0260) 2012; 161 OECD (bb0170) 2011 Darlenski, Fluhr (bb0050) 2012; 30 Patzelt, Lademann (bb0185) 2015 Pastore, Kalia, Horstmann, Roberts (bb0180) 2015; 172 Schätzlein, Cevc (bb0210) 1998; 138 Brodin, Steffansen, Nielsen (bb0040) 2010 Frasch, Bunge (bb0075) 2015; 104 Schenk, Rauma, Fransson, Johanson (bb0215) 2018; 13 Viljoen (10.1016/j.tiv.2020.104954_bb0265) 2015; 41 OECD (10.1016/j.tiv.2020.104954_bb0165) 2004 Baranowska-Dutkiewicz (10.1016/j.tiv.2020.104954_bb0015) 1981; 49 Franz (10.1016/j.tiv.2020.104954_bb0070) 1975; 64 Patzelt (10.1016/j.tiv.2020.104954_bb0185) 2015 Spencer (10.1016/j.tiv.2020.104954_bb0240) 1975; 93 Biniek (10.1016/j.tiv.2020.104954_bb0025) 2015; 80 Blank (10.1016/j.tiv.2020.104954_bb0030) 1967; 49 Schenk (10.1016/j.tiv.2020.104954_bb0215) 2018; 13 Darlenski (10.1016/j.tiv.2020.104954_bb0050) 2012; 30 Konda (10.1016/j.tiv.2020.104954_bb0115) 2012; 17 Le Fur (10.1016/j.tiv.2020.104954_bb0130) 2001; 117 Peck (10.1016/j.tiv.2020.104954_bb0190) 1995; 84 Frasch (10.1016/j.tiv.2020.104954_bb0080) 2014; 24 Silva (10.1016/j.tiv.2020.104954_bb0225) 2006; 19 Dennerlein (10.1016/j.tiv.2020.104954_bb0055) 2013; 27 Hughes (10.1016/j.tiv.2020.104954_bb0105) 1994; 8 Petersen (10.1016/j.tiv.2020.104954_bb0195) 2014; 13 Sindali (10.1016/j.tiv.2020.104954_bb0230) 2012; 6 Tanojo (10.1016/j.tiv.2020.104954_bb0245) 1999; 57 Schätzlein (10.1016/j.tiv.2020.104954_bb0210) 1998; 138 Olsztynska-Janus (10.1016/j.tiv.2020.104954_bb0175) 2018; 188 PubChem database (10.1016/j.tiv.2020.104954_bb0205) Fick (10.1016/j.tiv.2020.104954_bb0065) 1855; 170 Frasch (10.1016/j.tiv.2020.104954_bb0075) 2015; 104 OECD (10.1016/j.tiv.2020.104954_bb0160) 2004 Pastore (10.1016/j.tiv.2020.104954_bb0180) 2015; 172 Elias (10.1016/j.tiv.2020.104954_bb0060) 1981; 76 Blazejczyk (10.1016/j.tiv.2020.104954_bb0035) 1999; 1 Cua (10.1016/j.tiv.2020.104954_bb0045) 1990; 282 Notman (10.1016/j.tiv.2020.104954_bb0155) 2013; 65 Frölich (10.1016/j.tiv.2020.104954_bb0085) 2001; 93 Larsen (10.1016/j.tiv.2020.104954_bb0125) 2003; 93 van der Maaden (10.1016/j.tiv.2020.104954_bb0260) 2012; 161 Ngo (10.1016/j.tiv.2020.104954_bb0150) 2010; 30 Kodiweera (10.1016/j.tiv.2020.104954_bb0110) 2018; 107 Pham (10.1016/j.tiv.2020.104954_bb0200) 2017; 114 Lachenmeier (10.1016/j.tiv.2020.104954_bb0120) 2008; 3 10.1016/j.tiv.2020.104954_bb0090 Lee (10.1016/j.tiv.2020.104954_bb0135) 2006; 22 Machado (10.1016/j.tiv.2020.104954_bb0140) 2010; 32 Arens (10.1016/j.tiv.2020.104954_bb0010) 2006 Brodin (10.1016/j.tiv.2020.104954_bb0040) 2010 Holmgaard (10.1016/j.tiv.2020.104954_bb0100) 2013; 26 Ameen (10.1016/j.tiv.2020.104954_bb0005) 2017; 529 Menon (10.1016/j.tiv.2020.104954_bb0145) 1997; 10 OECD (10.1016/j.tiv.2020.104954_bb0170) 2011 (10.1016/j.tiv.2020.104954_bb0020) 2012 Scheuplein (10.1016/j.tiv.2020.104954_bb0220) 1971; 51 Vogt (10.1016/j.tiv.2020.104954_bb0270) 2005; 10 Teichmann (10.1016/j.tiv.2020.104954_bb0250) 2006; 19 Göen (10.1016/j.tiv.2020.104954_bb0095) 2020; 5 Smith (10.1016/j.tiv.2020.104954_bb0235) 1961; 36 Trommer (10.1016/j.tiv.2020.104954_bb0255) 2006; 19 |
| References_xml | – volume: 49 start-page: 99 year: 1981 end-page: 104 ident: bb0015 article-title: Skin absorption of phenol from aqueous solutions in men publication-title: Int. Arch. Occup. Environ. Health – volume: 188 start-page: 37 year: 2018 end-page: 49 ident: bb0175 article-title: ATR-IR study of skin components: lipids, proteins and water. Part I: temperature effect publication-title: Spectrochim. Acta A Mol. Biomol. Spectrosc. – volume: 117 start-page: 718 year: 2001 end-page: 724 ident: bb0130 article-title: Analysis of circadian and ultradian rhythms of skin surface properties of face and forearm of healthy women publication-title: J Invest Dermatol. – volume: 19 start-page: 132 year: 2006 end-page: 139 ident: bb0225 article-title: Thermal behaviour of human stratum corneum. A differential scanning calorimetry study at high scanning rates publication-title: Skin Pharmacol. Physiol. – volume: 30 start-page: 269 year: 2012 end-page: 273 ident: bb0050 article-title: Influence of skin type, race, sex, and anatomic location on epidermal barrier function publication-title: Clin. Dermatol. – volume: 26 start-page: 155 year: 2013 end-page: 159 ident: bb0100 article-title: Chronological age affects the permeation of fentanyl through human skin in vitro publication-title: Skin Pharmacol. Physiol. – volume: 107 start-page: 1131 year: 2018 end-page: 1142 ident: bb0110 article-title: Characterization of water self-diffusion in human stratum Corneum publication-title: J. Pharm. Sci. – volume: 10 start-page: 252 year: 2005 end-page: 255 ident: bb0270 article-title: Follicular targeting--a promising tool in selective dermatotherapy publication-title: J. Investig. Dermatol. Symp. Proc. – volume: 27 start-page: 708 year: 2013 end-page: 713 ident: bb0055 article-title: Studies on percutaneous penetration of chemicals - impact of storage conditions for excised human skin publication-title: Toxicol. in Vitro – volume: 13 start-page: 1123 year: 2014 end-page: 1125 ident: bb0195 article-title: Skin temperature during sunbathing--relevance for skin cancer publication-title: Photochem. Photobiol. Sci. – volume: 529 start-page: 465 year: 2017 end-page: 473 ident: bb0005 article-title: Transdermal delivery of dimethyl fumarate for Alzheimer’s disease: effect of penetration enhancers publication-title: Int. J. Pharm. – volume: 64 start-page: 190 year: 1975 end-page: 195 ident: bb0070 article-title: Percutaneous absorption. On the relevance of in vitro data publication-title: J Invest Dermatol. – volume: 76 start-page: 297 year: 1981 end-page: 301 ident: bb0060 article-title: Percutaneous transport in relation to stratum corneum structure and lipid composition publication-title: J Invest Dermatol. – volume: 41 start-page: 2045 year: 2015 end-page: 2054 ident: bb0265 article-title: Penetration enhancing effects of selected natural oils utilized in topical dosage forms publication-title: Drug Dev. Ind. Pharm. – volume: 93 start-page: 647 year: 2001 end-page: 648 ident: bb0085 article-title: Opioid overdose in a patient using a fentanyl patch during treatment with a warming blanket publication-title: Anesth. Analg. – volume: 8 start-page: 221 year: 1994 end-page: 227 ident: bb0105 article-title: Effect of age on the in vitro percutaneous absorption of phenols in mice publication-title: Toxicol. in Vitro – reference: GESTIS substance database. German Social Accident Insurance, information system on hazardous substances. – volume: 3 start-page: 26 year: 2008 ident: bb0120 article-title: Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity publication-title: J Occup Med Toxicol. – volume: 114 start-page: E112 year: 2017 end-page: E121 ident: bb0200 article-title: Tracking solvents in the skin through atomically resolved measurements of molecular mobility in intact stratum corneum publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 24 start-page: 65 year: 2014 end-page: 73 ident: bb0080 article-title: Analysis of finite dose dermal absorption data: implications for dermal exposure assessment publication-title: J. Exposure Sci. & Environ. Epidemiol. – start-page: 135 year: 2010 end-page: 151 ident: bb0040 article-title: Passive diffusion of drug substances: The concepts of flux and permeability publication-title: Molecular Biopharmaceutics: Aspects of Drug Characterisation, Drug Delivery and Dosage Form Evaluation – reference: (accessed 06. Jan. 2020). – volume: 36 start-page: 337 year: 1961 end-page: 343 ident: bb0235 article-title: The epidermal barrier publication-title: J. Investig. Dermatol. – volume: 1 start-page: 57 year: 1999 end-page: 60 ident: bb0035 article-title: Influence of solar radiation on skin temperature in standing and walking subjects outdoors publication-title: 8th Int Conf of Enviromental Ergonomics – volume: 282 start-page: 283 year: 1990 end-page: 288 ident: bb0045 article-title: Elastic properties of human skin: relation to age, sex, and anatomical region publication-title: Arch. Dermatol. Res. – volume: 170 start-page: 59 year: 1855 end-page: 86 ident: bb0065 article-title: Ueber Diffusion publication-title: Ann. Phys. Chem. – volume: 49 start-page: 582 year: 1967 end-page: 589 ident: bb0030 article-title: Mechanism of percutaneous absorption. 3. The effect of temperature on the transport of non-electrolytes across the skin publication-title: J Invest Dermatol. – year: 2011 ident: bb0170 article-title: Guidance notes on dermal absorption-GN 156 – volume: 6 start-page: 220 year: 2012 ident: bb0230 article-title: Life-threatening coma and full-thickness sunburn in a patient treated with transdermal fentanyl patches: a case report publication-title: J. Med. Case Rep. – volume: 30 start-page: 91 year: 2010 end-page: 114 ident: bb0150 article-title: Percutaneous absorption and exposure assessment of pesticides publication-title: J. Appl. Toxicol.: JAT. – volume: 57 start-page: 313 year: 1999 end-page: 322 ident: bb0245 article-title: Thermal analysis studies on human skin and skin barrier modulation by fatty acids and propylene glycol publication-title: J. Therm. Anal. Calorim. – volume: 19 start-page: 106 year: 2006 end-page: 121 ident: bb0255 article-title: Overcoming the stratum corneum: the modulation of skin penetration publication-title: Skin Pharmacol. Physiol. – volume: 19 start-page: 216 year: 2006 end-page: 223 ident: bb0250 article-title: Follicular penetration: development of a method to block the follicles selectively against the penetration of topically applied substances publication-title: Skin Pharmacol. Physiol. – volume: 172 start-page: 2179 year: 2015 end-page: 2209 ident: bb0180 article-title: Transdermal patches: history, development and pharmacology publication-title: Br. J. Pharmacol. – volume: 104 start-page: 1499 year: 2015 end-page: 1507 ident: bb0075 article-title: The transient dermal exposure II: post-exposure absorption and evaporation of volatile compounds publication-title: J. Pharm. Sci. – volume: 17 start-page: 1 year: 2012 end-page: 5 ident: bb0115 article-title: Age-related percutaneous penetration part 1: skin factors publication-title: Skin therapy letter. – start-page: 43 year: 2015 end-page: 53 ident: bb0185 article-title: The increasing importance of the hair follicle route in dermal and transdermal drug delivery publication-title: Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Drug Manipulation Strategies and Vehicle Effects – volume: 13 year: 2018 ident: bb0215 article-title: Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin publication-title: PLoS One – volume: 10 start-page: 235 year: 1997 end-page: 246 ident: bb0145 article-title: Morphologic basis for a pore-pathway in mammalian stratum corneum publication-title: Skin Pharmacol. – volume: 138 start-page: 583 year: 1998 end-page: 592 ident: bb0210 article-title: Non-uniform cellular packing of the stratum corneum andpermeability barrier function of intact skin: a high-resolutionconfocal laser scanning microscopy study using highlydeformable vesicles (Transfersomes) publication-title: Br. J. Dermatol. – start-page: 28 year: 2004 ident: bb0160 article-title: GUIDANCE DOCUMENT FOR THE CONDUCT OF SKIN ABSORPTION STUDIES GD28 – volume: 51 start-page: 702 year: 1971 end-page: 747 ident: bb0220 article-title: Permeability of the skin publication-title: Physiol. Rev. – year: 2012 ident: bb0020 publication-title: Transdermal and Topical Drug Delivery – volume: 65 start-page: 237 year: 2013 end-page: 250 ident: bb0155 article-title: Breaching the skin barrier — insights from molecular simulation of model membranes publication-title: Adv. Drug Deliv. Rev. – volume: 22 start-page: 148 year: 2006 end-page: 152 ident: bb0135 article-title: Minimal heating dose: a novel biological unit to measure infrared irradiation publication-title: Photodermatol. Photoimmunol. Photomed. – volume: 93 start-page: 244 year: 2003 end-page: 248 ident: bb0125 article-title: Dermal penetration of fentanyl: inter- and intraindividual variations publication-title: Pharmacol. Toxicol. – volume: 93 start-page: 159 year: 1975 end-page: 164 ident: bb0240 article-title: Temperature dependence of water content of stratum corneum publication-title: Br. J. Dermatol. – year: 2004 ident: bb0165 article-title: Guideline for the Testing of Chemicals, Skin Absorption, In Vitro Method-GL 428 OECD Environmental Health and Safety Publications – volume: 5 year: 2020 ident: bb0095 article-title: Alcohols, ketones and ethers – determination of alcohols, ketones and ethers in urine by headspace gaschromatography with mass spectrometric detection publication-title: MAK Collection for Occupational Health and Safety. – volume: 161 start-page: 645 year: 2012 end-page: 655 ident: bb0260 article-title: Microneedle technologies for (trans)dermal drug and vaccine delivery publication-title: J. Control. Release – volume: 32 start-page: 397 year: 2010 end-page: 409 ident: bb0140 article-title: Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity publication-title: Int. J. Cosmet. Sci. – volume: 84 start-page: 975 year: 1995 end-page: 982 ident: bb0190 article-title: The effect of temperature upon the permeation of polar and ionic solutes through human epidermal membrane publication-title: J. Pharm. Sci. – volume: 80 start-page: 94 year: 2015 end-page: 101 ident: bb0025 article-title: Understanding age-induced alterations to the biomechanical barrier function of human stratum corneum publication-title: J. Dermatol. Sci. – ident: bb0205 article-title: National Center for Biotechnology Information – start-page: 560 year: 2006 end-page: 602 ident: bb0010 article-title: The skin's role in human thermoregulation and comfort publication-title: Thermal and Moisture Transport in Fibrous Materials – volume: 57 start-page: 313 issue: 1 year: 1999 ident: 10.1016/j.tiv.2020.104954_bb0245 article-title: Thermal analysis studies on human skin and skin barrier modulation by fatty acids and propylene glycol publication-title: J. Therm. Anal. Calorim. doi: 10.1023/A:1010137807610 – volume: 64 start-page: 190 issue: 3 year: 1975 ident: 10.1016/j.tiv.2020.104954_bb0070 article-title: Percutaneous absorption. On the relevance of in vitro data publication-title: J Invest Dermatol. doi: 10.1111/1523-1747.ep12533356 – year: 2012 ident: 10.1016/j.tiv.2020.104954_bb0020 – volume: 93 start-page: 647 issue: 3 year: 2001 ident: 10.1016/j.tiv.2020.104954_bb0085 article-title: Opioid overdose in a patient using a fentanyl patch during treatment with a warming blanket publication-title: Anesth. Analg. doi: 10.1097/00000539-200109000-00023 – volume: 32 start-page: 397 issue: 6 year: 2010 ident: 10.1016/j.tiv.2020.104954_bb0140 article-title: Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity publication-title: Int. J. Cosmet. Sci. doi: 10.1111/j.1468-2494.2010.00587.x – volume: 24 start-page: 65 issue: 1 year: 2014 ident: 10.1016/j.tiv.2020.104954_bb0080 article-title: Analysis of finite dose dermal absorption data: implications for dermal exposure assessment publication-title: J. Exposure Sci. & Environ. Epidemiol. doi: 10.1038/jes.2013.23 – start-page: 135 year: 2010 ident: 10.1016/j.tiv.2020.104954_bb0040 article-title: Passive diffusion of drug substances: The concepts of flux and permeability – volume: 172 start-page: 2179 issue: 9 year: 2015 ident: 10.1016/j.tiv.2020.104954_bb0180 article-title: Transdermal patches: history, development and pharmacology publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13059 – volume: 36 start-page: 337 issue: 5 year: 1961 ident: 10.1016/j.tiv.2020.104954_bb0235 article-title: The epidermal barrier publication-title: J. Investig. Dermatol. doi: 10.1038/jid.1961.55 – volume: 76 start-page: 297 issue: 4 year: 1981 ident: 10.1016/j.tiv.2020.104954_bb0060 article-title: Percutaneous transport in relation to stratum corneum structure and lipid composition publication-title: J Invest Dermatol. doi: 10.1111/1523-1747.ep12526137 – start-page: 28 year: 2004 ident: 10.1016/j.tiv.2020.104954_bb0160 – volume: 10 start-page: 252 issue: 3 year: 2005 ident: 10.1016/j.tiv.2020.104954_bb0270 article-title: Follicular targeting--a promising tool in selective dermatotherapy publication-title: J. Investig. Dermatol. Symp. Proc. doi: 10.1111/j.1087-0024.2005.10124.x – volume: 107 start-page: 1131 issue: 4 year: 2018 ident: 10.1016/j.tiv.2020.104954_bb0110 article-title: Characterization of water self-diffusion in human stratum Corneum publication-title: J. Pharm. Sci. doi: 10.1016/j.xphs.2017.12.011 – volume: 188 start-page: 37 year: 2018 ident: 10.1016/j.tiv.2020.104954_bb0175 article-title: ATR-IR study of skin components: lipids, proteins and water. Part I: temperature effect publication-title: Spectrochim. Acta A Mol. Biomol. Spectrosc. doi: 10.1016/j.saa.2017.07.001 – volume: 104 start-page: 1499 issue: 4 year: 2015 ident: 10.1016/j.tiv.2020.104954_bb0075 article-title: The transient dermal exposure II: post-exposure absorption and evaporation of volatile compounds publication-title: J. Pharm. Sci. doi: 10.1002/jps.24334 – volume: 41 start-page: 2045 issue: 12 year: 2015 ident: 10.1016/j.tiv.2020.104954_bb0265 article-title: Penetration enhancing effects of selected natural oils utilized in topical dosage forms publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639045.2015.1047847 – volume: 10 start-page: 235 issue: 5–6 year: 1997 ident: 10.1016/j.tiv.2020.104954_bb0145 article-title: Morphologic basis for a pore-pathway in mammalian stratum corneum publication-title: Skin Pharmacol. doi: 10.1159/000211511 – volume: 13 start-page: 1123 issue: 8 year: 2014 ident: 10.1016/j.tiv.2020.104954_bb0195 article-title: Skin temperature during sunbathing--relevance for skin cancer publication-title: Photochem. Photobiol. Sci. doi: 10.1039/c4pp00066h – volume: 117 start-page: 718 issue: 3 year: 2001 ident: 10.1016/j.tiv.2020.104954_bb0130 article-title: Analysis of circadian and ultradian rhythms of skin surface properties of face and forearm of healthy women publication-title: J Invest Dermatol. doi: 10.1046/j.0022-202x.2001.01433.x – volume: 170 start-page: 59 issue: 1 year: 1855 ident: 10.1016/j.tiv.2020.104954_bb0065 article-title: Ueber Diffusion publication-title: Ann. Phys. Chem. doi: 10.1002/andp.18551700105 – volume: 13 issue: 10 year: 2018 ident: 10.1016/j.tiv.2020.104954_bb0215 article-title: Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin publication-title: PLoS One doi: 10.1371/journal.pone.0205458 – volume: 17 start-page: 1 issue: 5 year: 2012 ident: 10.1016/j.tiv.2020.104954_bb0115 article-title: Age-related percutaneous penetration part 1: skin factors publication-title: Skin therapy letter. – volume: 84 start-page: 975 issue: 8 year: 1995 ident: 10.1016/j.tiv.2020.104954_bb0190 article-title: The effect of temperature upon the permeation of polar and ionic solutes through human epidermal membrane publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600840813 – volume: 1 start-page: 57 year: 1999 ident: 10.1016/j.tiv.2020.104954_bb0035 article-title: Influence of solar radiation on skin temperature in standing and walking subjects outdoors – volume: 26 start-page: 155 issue: 3 year: 2013 ident: 10.1016/j.tiv.2020.104954_bb0100 article-title: Chronological age affects the permeation of fentanyl through human skin in vitro publication-title: Skin Pharmacol. Physiol. doi: 10.1159/000348876 – volume: 3 start-page: 26 year: 2008 ident: 10.1016/j.tiv.2020.104954_bb0120 article-title: Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity publication-title: J Occup Med Toxicol. doi: 10.1186/1745-6673-3-26 – volume: 49 start-page: 99 issue: 2 year: 1981 ident: 10.1016/j.tiv.2020.104954_bb0015 article-title: Skin absorption of phenol from aqueous solutions in men publication-title: Int. Arch. Occup. Environ. Health doi: 10.1007/BF00377662 – volume: 19 start-page: 132 issue: 3 year: 2006 ident: 10.1016/j.tiv.2020.104954_bb0225 article-title: Thermal behaviour of human stratum corneum. A differential scanning calorimetry study at high scanning rates publication-title: Skin Pharmacol. Physiol. doi: 10.1159/000092593 – volume: 8 start-page: 221 issue: 2 year: 1994 ident: 10.1016/j.tiv.2020.104954_bb0105 article-title: Effect of age on the in vitro percutaneous absorption of phenols in mice publication-title: Toxicol. in Vitro doi: 10.1016/0887-2333(94)90186-4 – volume: 529 start-page: 465 issue: 1–2 year: 2017 ident: 10.1016/j.tiv.2020.104954_bb0005 article-title: Transdermal delivery of dimethyl fumarate for Alzheimer’s disease: effect of penetration enhancers publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.07.031 – volume: 114 start-page: E112 issue: 2 year: 2017 ident: 10.1016/j.tiv.2020.104954_bb0200 article-title: Tracking solvents in the skin through atomically resolved measurements of molecular mobility in intact stratum corneum publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1608739114 – volume: 138 start-page: 583 year: 1998 ident: 10.1016/j.tiv.2020.104954_bb0210 article-title: Non-uniform cellular packing of the stratum corneum andpermeability barrier function of intact skin: a high-resolutionconfocal laser scanning microscopy study using highlydeformable vesicles (Transfersomes) publication-title: Br. J. Dermatol. doi: 10.1046/j.1365-2133.1998.02166.x – volume: 19 start-page: 106 issue: 2 year: 2006 ident: 10.1016/j.tiv.2020.104954_bb0255 article-title: Overcoming the stratum corneum: the modulation of skin penetration publication-title: Skin Pharmacol. Physiol. doi: 10.1159/000091978 – volume: 22 start-page: 148 issue: 3 year: 2006 ident: 10.1016/j.tiv.2020.104954_bb0135 article-title: Minimal heating dose: a novel biological unit to measure infrared irradiation publication-title: Photodermatol. Photoimmunol. Photomed. doi: 10.1111/j.1600-0781.2006.00201.x – volume: 161 start-page: 645 issue: 2 year: 2012 ident: 10.1016/j.tiv.2020.104954_bb0260 article-title: Microneedle technologies for (trans)dermal drug and vaccine delivery publication-title: J. Control. Release doi: 10.1016/j.jconrel.2012.01.042 – volume: 6 start-page: 220 year: 2012 ident: 10.1016/j.tiv.2020.104954_bb0230 article-title: Life-threatening coma and full-thickness sunburn in a patient treated with transdermal fentanyl patches: a case report publication-title: J. Med. Case Rep. doi: 10.1186/1752-1947-6-220 – volume: 80 start-page: 94 issue: 2 year: 2015 ident: 10.1016/j.tiv.2020.104954_bb0025 article-title: Understanding age-induced alterations to the biomechanical barrier function of human stratum corneum publication-title: J. Dermatol. Sci. doi: 10.1016/j.jdermsci.2015.07.016 – volume: 27 start-page: 708 issue: 2 year: 2013 ident: 10.1016/j.tiv.2020.104954_bb0055 article-title: Studies on percutaneous penetration of chemicals - impact of storage conditions for excised human skin publication-title: Toxicol. in Vitro doi: 10.1016/j.tiv.2012.11.016 – volume: 282 start-page: 283 issue: 5 year: 1990 ident: 10.1016/j.tiv.2020.104954_bb0045 article-title: Elastic properties of human skin: relation to age, sex, and anatomical region publication-title: Arch. Dermatol. Res. doi: 10.1007/BF00375720 – volume: 93 start-page: 244 issue: 5 year: 2003 ident: 10.1016/j.tiv.2020.104954_bb0125 article-title: Dermal penetration of fentanyl: inter- and intraindividual variations publication-title: Pharmacol. Toxicol. doi: 10.1046/j.1600-0773.2003.pto930508.x – start-page: 43 year: 2015 ident: 10.1016/j.tiv.2020.104954_bb0185 article-title: The increasing importance of the hair follicle route in dermal and transdermal drug delivery – volume: 19 start-page: 216 issue: 4 year: 2006 ident: 10.1016/j.tiv.2020.104954_bb0250 article-title: Follicular penetration: development of a method to block the follicles selectively against the penetration of topically applied substances publication-title: Skin Pharmacol. Physiol. doi: 10.1159/000093117 – start-page: 560 year: 2006 ident: 10.1016/j.tiv.2020.104954_bb0010 article-title: The skin's role in human thermoregulation and comfort – year: 2011 ident: 10.1016/j.tiv.2020.104954_bb0170 – volume: 30 start-page: 269 issue: 3 year: 2012 ident: 10.1016/j.tiv.2020.104954_bb0050 article-title: Influence of skin type, race, sex, and anatomic location on epidermal barrier function publication-title: Clin. Dermatol. doi: 10.1016/j.clindermatol.2011.08.013 – volume: 5 year: 2020 ident: 10.1016/j.tiv.2020.104954_bb0095 article-title: Alcohols, ketones and ethers – determination of alcohols, ketones and ethers in urine by headspace gaschromatography with mass spectrometric detection publication-title: MAK Collection for Occupational Health and Safety. – volume: 93 start-page: 159 issue: 2 year: 1975 ident: 10.1016/j.tiv.2020.104954_bb0240 article-title: Temperature dependence of water content of stratum corneum publication-title: Br. J. Dermatol. doi: 10.1111/j.1365-2133.1975.tb06735.x – volume: 49 start-page: 582 issue: 6 year: 1967 ident: 10.1016/j.tiv.2020.104954_bb0030 article-title: Mechanism of percutaneous absorption. 3. The effect of temperature on the transport of non-electrolytes across the skin publication-title: J Invest Dermatol. doi: 10.1038/jid.1967.184 – year: 2004 ident: 10.1016/j.tiv.2020.104954_bb0165 – ident: 10.1016/j.tiv.2020.104954_bb0090 – volume: 65 start-page: 237 issue: 2 year: 2013 ident: 10.1016/j.tiv.2020.104954_bb0155 article-title: Breaching the skin barrier — insights from molecular simulation of model membranes publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2012.02.011 – volume: 51 start-page: 702 issue: 4 year: 1971 ident: 10.1016/j.tiv.2020.104954_bb0220 article-title: Permeability of the skin publication-title: Physiol. Rev. doi: 10.1152/physrev.1971.51.4.702 – ident: 10.1016/j.tiv.2020.104954_bb0205 – volume: 30 start-page: 91 issue: 2 year: 2010 ident: 10.1016/j.tiv.2020.104954_bb0150 article-title: Percutaneous absorption and exposure assessment of pesticides publication-title: J. Appl. Toxicol.: JAT. doi: 10.1002/jat.1505 |
| SSID | ssj0005820 |
| Score | 2.296194 |
| Snippet | Skin temperature plays a certain role in the dermal absorption of substances, but the extent and mechanisms of skin temperatures-induced modulation in ranges... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 104954 |
| SubjectTerms | Absorption Anisole Anisoles - metabolism Blood circulation Dermal absorption Diffusion cell Diffusion cells Dioxanes - metabolism Environmental conditions Ethanol Ethanol - metabolism Exposure Humans Influence of temperature Lipids Lipophilic Modulation Penetration Perfusion Skin Skin - metabolism Skin Absorption Skin temperature Temperature Temperature dependence Thermoregulation Transdermal penetration |
| Title | Impact of physiologically relevant temperatures on dermal absorption of active substances - an ex-vivo study in human skin |
| URI | https://dx.doi.org/10.1016/j.tiv.2020.104954 https://www.ncbi.nlm.nih.gov/pubmed/32738276 https://www.proquest.com/docview/2448951812 https://www.proquest.com/docview/2429778314 |
| Volume | 68 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-3177 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005820 issn: 0887-2333 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1da9swFBVpO9hgjK37ytYVDUYf5jrY8vdjV7qthZXAspE3I0s2OAt2iF2T7A_sb-_KkuwsI2V92IsJtiQU7vHxvVfSuQi9S7iTcQpBTuBTy3RdnplJxqgZhpGdUErBI3HbYhPB9XU4nUbjweCXPgvTzIOiCFeraPFfTQ33wNji6OwdzN0NCjfgNxgdrmB2uP6T4S-7c49t1kKT23zd1kcBx7k2hB6VElNuVwu4oOe5QZOqXC60C0lbJjQqYJZaQKMyTIOKkgBmkzel1KUV2RJZ5a_6oSS8laM7KVc5k_pO0KbJ62W5sdzf5me_jvqkjyTlq-7Ol7zIje_5jK5VgrZ78kks7X_wJVtORptZCwhR9f63TXIjjhTB0EwsC-woKoU4MZL60n-xvEw4zOCj3ozE4KO-7Z-K2ltfum7_od7aNothiFgMEcsh9tABCbwI6PHg7PJietXvFgqlwqeetl4gb7cKbs1jl4uzK4RpXZnJY_RIxSD4TGLnCRqkxSG6f65L_x2ik7EUNF-f4kl_Pq86xSd43EudQ8OHMuuL5WG2p-inBB8uM7wFPqzBhzfBh8sCS_DhHnyitwQf7sGHTUwLrMCHW_DhvMAt-LAA3zP07ePF5Pyzqap7mIxEfg1skHicWNQPk5STLOIu5x7xUtdmLnPArc6YR_2MpglNAo85jh9EFiV2anssypjlPEf7RVmkLxEOIMhPPOhgk8RNuUWjlJLEDrhj2z733CGytEFipqTvRQWWebwTCEP0vuuykLovtzV2tZVj5bhKhzQGxN7W7UgjIlYEUsXgbocQ9YDfPURvu8dgf7GQR4u0vBFtCIRtoWPDEC8kkrpJOuKsHQn8V3f5A6_Rg_4lPUL79fImfYPusabOq-Ux2gum4bF6I34D1ubaag |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Impact+of+physiologically+relevant+temperatures+on+dermal+absorption+of+active+substances+-+an+ex-vivo+study+in+human+skin&rft.jtitle=Toxicology+in+vitro&rft.au=Kilo%2C+S.&rft.au=Wick%2C+J.&rft.au=Mini+Vijayan%2C+S.&rft.au=G%C3%B6en%2C+T.&rft.date=2020-10-01&rft.issn=0887-2333&rft.volume=68&rft.spage=104954&rft_id=info:doi/10.1016%2Fj.tiv.2020.104954&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_tiv_2020_104954 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0887-2333&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0887-2333&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0887-2333&client=summon |