Ru(ii)-catalysed oxidative (4+2) annulation of chromene and coumarin carboxylic acids with alkynes/propargylic alcohols: isolation of Ru(0) complexes

Ru(ii)-catalysed oxidative (4 + 2) annulation of chromene and coumarin-3-carboxylic acids with alkynes/propargylic alcohols via sp(2) C-H bond activation is reported. While the reaction with alkynes affords highly substituted pyrano-chromones in good to excellent yields, the use of methyl-tethered p...

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Vydáno v:Organic & biomolecular chemistry Ročník 21; číslo 1; s. 195 - 208
Hlavní autoři: Shankar, Mallepalli, Swamy, K. C. Kumara
Médium: Journal Article
Jazyk:angličtina
Vydáno: CAMBRIDGE Royal Soc Chemistry 21.12.2022
Témata:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
H BOND ACTIVATION
FUNCTIONALIZATION
ACRYLIC-ACIDS
AROMATIC-ACIDS
ALPHA-PYRONES
ISOCOUMARINS
ALKYNES
DERIVATIVES
CYCLIZATION
BENZOIC-ACIDS
ISSN:1477-0520, 1477-0539, 1477-0539
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Shrnutí:Ru(ii)-catalysed oxidative (4 + 2) annulation of chromene and coumarin-3-carboxylic acids with alkynes/propargylic alcohols via sp(2) C-H bond activation is reported. While the reaction with alkynes affords highly substituted pyrano-chromones in good to excellent yields, the use of methyl-tethered propargylic alcohols in place of alkynes leads to novel Ru(0)-metal complexes in moderate to good yields; these complexes were stable in MeCO2H/O-2. The generality of the reaction with alkynes is illustrated in the case of both symmetrical and unsymmetrical internal alkynes with excellent regioselectivity in the case of unsymmetrical alkynes.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d2ob01890j