Protective effects of Aristolochia longa and Aquilaria malaccensis against lead induced acute liver injury in rats

Objective: To investigate the protective effects of Aristolochia longa (A. longa) and Aquilaria malaccensis (A. malaccensis) on acute hepatotoxicity induced by lead in female albino rats. Methods: Twenty five (25) apparently healthy female Wistar rats were randomly divided into five groups of five r...

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Vydáno v:Journal of acute disease Ročník 6; číslo 5; s. 193 - 197
Hlavní autoři: Samir, Derouiche, Khaoula, Zeghib, Safa, Gharbi, Yahia, Khelef, Anouar, Feriani
Médium: Journal Article
Jazyk:angličtina
Vydáno: Medknow Publications and Media Pvt. Ltd 01.09.2017
Department of Cellular and Molecular Biology, Faculty of natural science and life, University of Echahid Hamma Lakhdar-Eloued , El-oued 39000, El-oued,Algeria%Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia
Wolters Kluwer Medknow Publications
Témata:
Acetate lead
Acute hepatotoxicity
Albinism
Aquilaria malaccensis
Aristolochia longa
Drinking water
Health aspects
Laboratory rats
Lead compounds
Liver
Oxidative stress
Stress oxidative
Water
Aristolochia longa
Acetate lead
Stress oxidative
Aquilaria malaccensis
Acute hepatotoxicity
ISSN:2221-6189, 2221-6189
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Abstract Objective: To investigate the protective effects of Aristolochia longa (A. longa) and Aquilaria malaccensis (A. malaccensis) on acute hepatotoxicity induced by lead in female albino rats. Methods: Twenty five (25) apparently healthy female Wistar rats were randomly divided into five groups of five rats in each: control, Pb, Pb + A. longa (Ar), Pb+ A. malaccensis (Aq), and Pb+ A. longa (Ar) + A. malaccensis (Aq) lead (100 mg/kg b.w.) as Pb (C2H3O2)2 added in their drinking water for 75 days. A. longa (rhizome powder at a dose of 10 g/kg of diet ) and A. malaccensis (heartwood powder at a dose 10 g/kg of diet) were added to the feed during the last 15 days of lead exposed in the animals. Results: Obtained results revealed that lead treatment caused a significant increase in serum GOT, GPT and ALP activities and in liver of MDA level and CAT activity. In contrast, it led to an decrease in the liver GOT, GPT and GST activities and in GSH level in rats. Also, the results clearly showed that lead causes alterations of hepatic tissue in comparison with controls. Our results showed that treatment with A. malaccensis and A. longa a partial correction of the previous parameters. The histological observations confirmed the hepatoprotection results by the biochemical parameters. Conclusions: Results demonstrated beneficial effects of A. longa and A. malaccensis treatment in Pb-induced oxidative stress and tissue damage in liver.
AbstractList Objective: To investigate the protective effects of Aristolochia longa (A. longa) and Aquilaria malaccensis (A. malaccensis) on acute hepatotoxicity induced by lead in female albino rats.Methods: Twenty five (25) apparently healthy female Wistar rats were randomly divided into five groups of five rats in each: control, Pb, Pb + A. longa (Ar), Pb+ A. malaccensis (Aq), and Pb+ A. longa (Ar) + A. malaccensis (Aq) lead (100 mg/kg b.w.) as Pb (C2H3O2)2 added in their drinking water for 75 days. A. longa (rhizome powder at a dose of 10 g/kg of diet) and A. malaccensis (heartwood powder at a dose 10 g/kg of diet) were added to the feed during the last 15 days of lead exposed in the animals.Results: Obtained results revealed that lead treatment caused a significant increase in serum GOT, GPT and ALP activities and in liver of MDA level and CAT activity. In contrast, it led to an decrease in the liver GOT, GPT and GST activities and in GSH level in rats. Also, the results clearly showed that lead causes alterations of hepatic tissue in comparison with controls. Our results showed that treatment with A. malaccensis and A. longa a partial correction of the previous parameters. The histological observations confirmed the hepatoprotection results by the biochemical parameters.Conclusions: Results demonstrated beneficial effects of A. longa and A. malaccensis treatment in Pb-induced oxidative stress and tissue damage in liver.
Audience Academic
Author Safa, Gharbi
Yahia, Khelef
Anouar, Feriani
Samir, Derouiche
Khaoula, Zeghib
AuthorAffiliation Department of Cellular and Molecular Biology, Faculty of natural science and life, University of Echahid Hamma Lakhdar-Eloued , El-oued 39000, El-oued,Algeria%Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia
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CitedBy_id crossref_primary_10_1007_s11356_020_10161_z
crossref_primary_10_1016_j_sciaf_2024_e02186
crossref_primary_10_1016_j_sajb_2022_10_020
crossref_primary_10_1080_01480545_2020_1775630
crossref_primary_10_52711_0974_360X_2022_00572
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Keywords Aristolochia longa
Acetate lead
Stress oxidative
Aquilaria malaccensis
Acute hepatotoxicity
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Department of Cellular and Molecular Biology, Faculty of natural science and life, University of Echahid Hamma Lakhdar-Eloued , El-oued 39000, El-oued,Algeria%Laboratory of Animal Ecophysiology, Faculty of Science of Sfax, 3018 Sfax, Tunisia
Wolters Kluwer Medknow Publications
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SubjectTerms Acetate lead
Acute hepatotoxicity
Albinism
Aquilaria malaccensis
Aristolochia longa
Drinking water
Health aspects
Laboratory rats
Lead compounds
Liver
Oxidative stress
Stress oxidative
Water
Title Protective effects of Aristolochia longa and Aquilaria malaccensis against lead induced acute liver injury in rats
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