The Role of Substance P in Neurodegenerative Diseases

Abstract- Tachykinins (TKs) are a family of neuropeptides widely distributed in the human body, especially in the nervous system. TKs have exhibited both neuroprotective and neurodegenerative properties in the central nervous system (CNS) and spinal cord. Also, several studies have shown that substa...

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Bibliographic Details
Published in:Acta medica Iranica Vol. 58; no. 7; p. 301
Main Authors: Ghahremanloo, Atefeh, Mohammadi, Fariba, Hashemy, Seyed Isaac
Format: Journal Article
Language:English
Published: Tehran Tehran University of Medical Sciences 2020
Subjects:
Amino acids
Amyotrophic lateral sclerosis
Biomarkers
Brain research
Disease
Huntingtons disease
Mammals
Multiple sclerosis
Nervous system
Neuropeptides
Neurotoxicity
Parkinson's disease
Pathogenesis
Peptides
Roles
Spinal cord
ISSN:0044-6025, 1735-9694
Online Access:Get full text
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Summary:Abstract- Tachykinins (TKs) are a family of neuropeptides widely distributed in the human body, especially in the nervous system. TKs have exhibited both neuroprotective and neurodegenerative properties in the central nervous system (CNS) and spinal cord. Also, several studies have shown that substance P (SP), as a pioneering neuropeptide of the TK family, is engaged in the pathogenesis of neurodegenerative disorders (NDs), such as Alzheimer disease, Multiple Sclerosis, Parkinson’s disease, Huntington’s disease, and Amyotrophic lateral sclerosis. However, a huge body of information available about the level of SP in NDs demonstrates that SP and its receptors might be prognostic or diagnostic factors for NDs. The present review article summarizes the roles of TKs in common neurodegenerative disorders.
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ISSN:0044-6025
1735-9694
DOI:10.18502/acta.v58i7.4416