Dose Reduction in Molecular Breast Imaging With a New Image-Processing Algorithm

The purpose of this study was to determine whether application of a proprietary image-processing algorithm would allow a reduction in the necessary administered activity for molecular breast imaging (MBI) examinations. Images from standard-dose MBI examinations (300 MBq Tc-sestamibi) of 50 subjects...

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Bibliographic Details
Published in:American journal of roentgenology (1976) Vol. 214; no. 1; p. 185
Main Authors: Tao, Ashley T, Hruska, Carrie B, Conners, Amy L, Hunt, Katie N, Swanson, Tiffinee N, Tran, Thuy D, Manduca, Armando, Borges, Lucas, Maidment, Andrew D A, Lake, David, Johnson, Matthew P, Carter, Rickey E, Rhodes, Deborah J, O'Connor, Michael K
Format: Journal Article
Language:English
Published: United States 01.01.2020
Subjects:
Aged
Algorithms
Breast Diseases - diagnostic imaging
Breast Neoplasms - diagnostic imaging
Female
Humans
Image Processing, Computer-Assisted
Middle Aged
Molecular Imaging - methods
Radiation Dosage
Radionuclide Imaging
dose reduction
breast cancer
molecular breast imaging
two-alternative forced choice
cadmium zinc telluride
ISSN:1546-3141, 1546-3141
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Summary:The purpose of this study was to determine whether application of a proprietary image-processing algorithm would allow a reduction in the necessary administered activity for molecular breast imaging (MBI) examinations. Images from standard-dose MBI examinations (300 MBq Tc-sestamibi) of 50 subjects were analyzed. The images were acquired in dynamic mode and showed at least one breast lesion. Half-dose MBI examinations were simulated by summing one-half of the dynamic frames and were processed with the algorithm under study in both a default and a preferred filter mode. Two breast radiologists independently completed a set of two-alternative forced-choice tasks to compare lesion conspicuity on standard-dose images, half-dose images, and the algorithm-processed half-dose images in both modes. Relative to the standard-dose images, the half-dose images were preferred in 4, the default-filtered half-dose images in 50, and preferred-filtered half-dose images in 76 of 100 readings. Compared with standard-dose images, in terms of lesion conspicuity, the half-dose images were rated better in 2, equivalent in 6, and poorer in 92 of 100 readings. The default-filtered half-dose images were rated better, equivalent, or poorer in 13, 73, and 14 of 100 readings. The preferred-filtered half-dose images were rated as better, equivalent, or poorer in 55, 34, and 11 of 100 readings. Compared with that on standard-dose images, lesion conspicuity on images obtained with the algorithm and acquired at one-half the standard dose was equivalent or better without compromise of image quality. The algorithm can also be used to decrease imaging time with a resulting increase in patient comfort and throughput.
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ISSN:1546-3141
1546-3141
DOI:10.2214/AJR.19.21582