Elevated LDL-C, high blood pressure, and low peak V̇O2 associate with platelet mitochondria function in children—The Arkansas Active Kids Study
Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years. Methods: PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respirati...
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| Veröffentlicht in: | Frontiers in molecular biosciences Jg. 10; S. 1136975 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Frontiers Media S.A
22.03.2023
|
| Schlagworte: | |
| ISSN: | 2296-889X, 2296-889X |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Purpose:
To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years.
Methods:
PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CII
E
) were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI leak respiration (P
CI
/L
CI
). Peak
V
.
O
2
(incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics.
Results:
R and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak
V
.
O
2
. R and CI-linked respiration had inverse association with age and elevated LDL-C. CII
E
was higher in children with elevated LDL-C (log-β = −0.54,
p
= 0.010). HBP and peak
V
.
O
2
interacted in relation to RCR (log-β = −0.01,
p
= 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak
V
.
O
2
-1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration.
Conclusion:
In PL, R and CI-linked mitochondrial respiration directly associate with adiposity, peak
V
.
O
2
and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status. |
|---|---|
| Bibliographie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: David Pacheu-Grau, University of Zaragoza, Spain Lokendra Kumar Sharma, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGI), India This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences Edited by: Marta Zarà, Monzino Cardiology Center (IRCCS), Italy |
| ISSN: | 2296-889X 2296-889X |
| DOI: | 10.3389/fmolb.2023.1136975 |