Elevated LDL-C, high blood pressure, and low peak V̇O2 associate with platelet mitochondria function in children—The Arkansas Active Kids Study
Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years. Methods: PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respirati...
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| Vydáno v: | Frontiers in molecular biosciences Ročník 10; s. 1136975 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Frontiers Media S.A
22.03.2023
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| ISSN: | 2296-889X, 2296-889X |
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| Abstract | Purpose:
To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years.
Methods:
PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CII
E
) were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI leak respiration (P
CI
/L
CI
). Peak
V
.
O
2
(incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics.
Results:
R and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak
V
.
O
2
. R and CI-linked respiration had inverse association with age and elevated LDL-C. CII
E
was higher in children with elevated LDL-C (log-β = −0.54,
p
= 0.010). HBP and peak
V
.
O
2
interacted in relation to RCR (log-β = −0.01,
p
= 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak
V
.
O
2
-1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration.
Conclusion:
In PL, R and CI-linked mitochondrial respiration directly associate with adiposity, peak
V
.
O
2
and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status. |
|---|---|
| AbstractList | Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years.
Methods: PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CIIE) were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI leak respiration (PCI/LCI). Peak
V˙
O2 (incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics.
Results: R and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak
V˙
O2. R and CI-linked respiration had inverse association with age and elevated LDL-C. CIIE was higher in children with elevated LDL-C (log-β = −0.54, p = 0.010). HBP and peak
V˙
O2 interacted in relation to RCR (log-β = −0.01, p = 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak
V˙
O2 -1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration.
Conclusion: In PL, R and CI-linked mitochondrial respiration directly associate with adiposity, peak
V˙
O2 and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status. Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7-10 years. Methods: PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CIIE) were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI leak respiration (PCI/LCI). Peak V ˙ O2 (incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics. Results: R and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak V ˙ O2. R and CI-linked respiration had inverse association with age and elevated LDL-C. CIIE was higher in children with elevated LDL-C (log-β = -0.54, p = 0.010). HBP and peak V ˙ O2 interacted in relation to RCR (log-β = -0.01, p = 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak V ˙ O2 -1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration. Conclusion: In PL, R and CI-linked mitochondrial respiration directly associate with adiposity, peak V ˙ O2 and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status.Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7-10 years. Methods: PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CIIE) were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI leak respiration (PCI/LCI). Peak V ˙ O2 (incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics. Results: R and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak V ˙ O2. R and CI-linked respiration had inverse association with age and elevated LDL-C. CIIE was higher in children with elevated LDL-C (log-β = -0.54, p = 0.010). HBP and peak V ˙ O2 interacted in relation to RCR (log-β = -0.01, p = 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak V ˙ O2 -1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration. Conclusion: In PL, R and CI-linked mitochondrial respiration directly associate with adiposity, peak V ˙ O2 and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status. Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years.Methods: PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CIIE) were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI leak respiration (PCI/LCI). Peak V̇O2 (incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics.Results: R and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak V̇O2. R and CI-linked respiration had inverse association with age and elevated LDL-C. CIIE was higher in children with elevated LDL-C (log-β = −0.54, p = 0.010). HBP and peak V̇O2 interacted in relation to RCR (log-β = −0.01, p = 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak V̇O2 -1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration.Conclusion: In PL, R and CI-linked mitochondrial respiration directly associate with adiposity, peak V̇O2 and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status. Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years. Methods: PL mitochondrial respiration (n = 91) was assessed by high resolution respirometry (HRR): Routine (R) respiration, complex (C) I linked respiration (CI), and maximal uncoupled electron transport capacity of CII (CII E ) were measured. The respiratory control ratio (RCR) was calculated as the ratio of maximal oxidative phosphorylation capacity of CI and CI leak respiration (P CI /L CI ). Peak V . O 2 (incremental bike test) and body composition (dual-energy X-ray absorptiometry) were measured. Multiple generalized linear regression analysis was used to model the association of measures by HRR with variables of interest: adiposity, low-density lipoprotein (LDL-C) and triglyceride (TG) status (normal vs. elevated) HOMA2-IR, blood pressure status (normal vs. high), and demographics. Results: R and CI-linked respiration positively associated with adiposity, high blood pressure (HBP), and peak V . O 2 . R and CI-linked respiration had inverse association with age and elevated LDL-C. CII E was higher in children with elevated LDL-C (log-β = −0.54, p = 0.010). HBP and peak V . O 2 interacted in relation to RCR (log-β = −0.01, p = 0.028). Specifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak V . O 2 -1SD). HOMA2-IR did not associate with measures of PL mitochondria respiration. Conclusion: In PL, R and CI-linked mitochondrial respiration directly associate with adiposity, peak V . O 2 and HBP. Elevated LDL-C associates with lower CI-linked respiration which is compensated by increasing CII respiration. PL bioenergetics phenotypes in children associate with whole-body metabolic health status. |
| Author | Adams, Sean H. Cotter, Matthew Børsheim, Elisabet Weber, Judith L. Diaz, Eva C. |
| AuthorAffiliation | 4 Department of Surgery , and Center for Alimentary and Metabolic Science , University of California , Davis , School of Medicine , Sacramento , CA , United States 5 Department of Nursing Science , College of Nursing , University of Arkansas for Medical Sciences , Little Rock , AR , United States 2 Arkansas Children’s Research Institute , Little Rock , AR , United States 3 Department of Pediatrics , College of Medicine , University of Arkansas for Medical Sciences , Little Rock , AR , United States 1 Arkansas Children’s Nutrition Center , Little Rock , AR , United States |
| AuthorAffiliation_xml | – name: 4 Department of Surgery , and Center for Alimentary and Metabolic Science , University of California , Davis , School of Medicine , Sacramento , CA , United States – name: 3 Department of Pediatrics , College of Medicine , University of Arkansas for Medical Sciences , Little Rock , AR , United States – name: 2 Arkansas Children’s Research Institute , Little Rock , AR , United States – name: 1 Arkansas Children’s Nutrition Center , Little Rock , AR , United States – name: 5 Department of Nursing Science , College of Nursing , University of Arkansas for Medical Sciences , Little Rock , AR , United States |
| Author_xml | – sequence: 1 givenname: Eva C. surname: Diaz fullname: Diaz, Eva C. – sequence: 2 givenname: Sean H. surname: Adams fullname: Adams, Sean H. – sequence: 3 givenname: Judith L. surname: Weber fullname: Weber, Judith L. – sequence: 4 givenname: Matthew surname: Cotter fullname: Cotter, Matthew – sequence: 5 givenname: Elisabet surname: Børsheim fullname: Børsheim, Elisabet |
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| CitedBy_id | crossref_primary_10_1016_j_jbc_2023_105470 |
| Cites_doi | 10.1096/fj.04-2173com 10.1126/science.1230381 10.1152/ajpendo.00475.2015 10.1172/jci.insight.91415 10.1177/0260106020975571 10.1249/MSS.0000000000002701 10.1038/srep36222 10.1042/BSR20120034 10.1172/jci.insight.128248 10.1177/0885066616658449 10.1542/peds.2017-1904 10.1007/s00415-015-7737-0 10.1002/ana.20570 10.1055/s-0038-1642738 10.1016/j.mito.2019.07.013 10.1182/blood.v42.6.913.913 10.1111/j.1476-5381.2012.01911.x 10.1152/ajpendo.00084.2019 10.3945/ajcn.112.053611 10.1160/TH13-12-1026 10.1016/j.lfs.2016.02.030 10.1172/JCI106211 10.1093/cvr/cvn015 10.1080/09537100020000157 10.3390/ijms23010388 10.1016/0003-9861(72)90391-8 10.1016/j.cmet.2014.04.015 10.1111/j.1651-2227.1971.tb05688.x 10.1182/blood-2013-11-462432 10.1016/j.ijcard.2018.07.104 10.1542/peds.2009-2107C 10.1371/journal.pone.0256135 10.1182/blood-2002-07-2209 10.1186/1751-0473-3-17 10.1096/fj.202000767R 10.26124/BEC:2020-0002 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Diaz, Adams, Weber, Cotter and Børsheim. Copyright © 2023 Diaz, Adams, Weber, Cotter and Børsheim. 2023 Diaz, Adams, Weber, Cotter and Børsheim |
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| Snippet | Purpose:
To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years.
Methods:
PL... Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7-10 years. Methods: PL... Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years. Methods: PL... Purpose: To evaluate the association of platelet (PL) mitochondria respiration with markers of cardiovascular health in children ages 7–10 years.Methods: PL... |
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| SubjectTerms | aerobic capacity blood platelets body composition cardiometabolic risk (factors) mitochondria Molecular Biosciences |
| Title | Elevated LDL-C, high blood pressure, and low peak V̇O2 associate with platelet mitochondria function in children—The Arkansas Active Kids Study |
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