NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects Case report and literature review

Azathioprine (AZA) is widely used as an immunosuppressive agent, and its efficacy has been recommended by many clinical studies. However, leukopenia, the most common toxicity, still restricts its clinical applications. Recent studies found that NUDT15 R139C polymorphism is strongly associated with A...

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Bibliographic Details

Published in:	Medicine (Baltimore) Vol. 97; no. 17; p. e0301
Main Authors:	Fei, Xiang, Shu, Qing, Hua, Bing-zhu, Wang, Shi-ying, Chen, Zhi-yong, Ge, Wei-hong, Fang, Yun
Format:	Journal Article
Language:	English
Published:	United States Wolters Kluwer Health 01.04.2018
Subjects:	Azathioprine - pharmacokinetics Clinical Case Report Female Genotype Humans Methyltransferases - genetics Polymorphism, Single Nucleotide Pyrophosphatases - genetics Sjogren's Syndrome - genetics Young Adult
ISSN:	0025-7974, 1536-5964, 1536-5964
Online Access:	Get full text
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