Identification of SHANK2 Pathogenic Variants in a Chinese Uygur Population with Schizophrenia

Genomic studies on schizophrenia (SCZ) have revealed several candidate genes involved in excitatory synapse function and plasticity associated with its etiology. SHANK2 is a postsynaptic scaffolding protein, which anchors a protein complex connecting NMDAR, AMPAR, and mGluR receptors at excitatory n...

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Vydané v:	Journal of molecular neuroscience Ročník 71; číslo 1; s. 1 - 8
Hlavní autori:	Zhang, Han, Wang, Dong, Chen, Jianhua, Li, Xiuli, Yi, Qizhong, Shi, Yongyong
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Springer US 01.01.2021 Springer Nature B.V
Predmet:	Autism Biomedical and Life Sciences Biomedicine Cell Biology Etiology Glutamate receptors Glutamic acid receptors (metabotropic) Mental disorders Mutation N-Methyl-D-aspartic acid receptors Neurochemistry Neurology Neurosciences Population studies Proteins Proteomics Scaffolding Schizophrenia Synapses α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors Schizophrenia Rare novel variant gene Uygur Chinese SHANK2 gene
ISSN:	0895-8696, 1559-1166, 1559-1166
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