Photogenerator of trichloroacetic acid as a promising detritylation agent for oligonucleotide microarray synthesis

[[4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl]-2,2,2-trichloroacetate, which generates trichloroacetic acid when irradiated with light of 405 nm wavelength, has been studied as a detritylation agent in the oligonucleotide microarray synthesis. This agent was shown to be suitable for the de...

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Vydáno v:Russian journal of bioorganic chemistry Ročník 40; číslo 5; s. 586 - 588
Hlavní autoři: Sinyakov, A. N., Nikolaenkova, E. B., Os’kina, I. A., Savel’ev, V. A., Samsonov, V. A., Tikhonov, A. Y., Palatkina, M. Yu, Zaytsev, D. E.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Moscow Pleiades Publishing 01.09.2014
Témata:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Organic Chemistry
oligodeoxyribonucleotides
trityl cation
photogenerated acids
ISSN:1068-1620, 1608-330X
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Shrnutí:[[4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl]-2,2,2-trichloroacetate, which generates trichloroacetic acid when irradiated with light of 405 nm wavelength, has been studied as a detritylation agent in the oligonucleotide microarray synthesis. This agent was shown to be suitable for the deprotection of the 4,4′-dimethoxytrityl group during the solid phase oligonucleotide synthesis.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162014050124