Fatigue, anxiety, depression and quality of life in kidney transplant recipients, haemodialysis patients, patients with a haematological malignancy and healthy controls

The impact of haemodialysis (HD) and kidney transplantation on quality of life (QoL) is often underestimated due to a lack of comparative studies with other patient groups. We conducted a cross-sectional cohort study in 168 patients including HD patients, kidney transplant recipients (KTR), patients...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation Vol. 34; no. 5; p. 833
Main Authors: van Sandwijk, Marit S, Al Arashi, Doaa, van de Hare, Fons M, van der Torren, J M Rolien, Kersten, Marie-José, Bijlsma, Joost A, Ten Berge, Ineke J M, Bemelman, Frederike J
Format: Journal Article
Language:English
Published: England 01.05.2019
Subjects:
Anxiety - epidemiology
Anxiety - etiology
Anxiety - psychology
Cross-Sectional Studies
Depression - epidemiology
Depression - etiology
Depression - psychology
Fatigue - epidemiology
Fatigue - etiology
Fatigue - psychology
Female
Follow-Up Studies
Hematologic Neoplasms - therapy
Humans
Incidence
Kidney Transplantation - psychology
Male
Middle Aged
Netherlands - epidemiology
Quality of Life
Renal Dialysis - psychology
Surveys and Questionnaires
Transplant Recipients - psychology
Netherlands
haemodialysis
malignancy
haemato-oncology
quality of life
kidney transplantation
ISSN:1460-2385, 1460-2385
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Summary:The impact of haemodialysis (HD) and kidney transplantation on quality of life (QoL) is often underestimated due to a lack of comparative studies with other patient groups. We conducted a cross-sectional cohort study in 168 patients including HD patients, kidney transplant recipients (KTR), patients with a haematological malignancy either receiving chemotherapy or in remission and healthy controls. All participants completed the 36-item short form survey of health-related quality of life, the Checklist Individual Strength and the Hospital Anxiety and Depression Scale questionnaire. HD patients and haematological patients undergoing chemotherapy were more frequently severely fatigued (53.3% and 50% of cases) compared with KTR (33.3%), haematological patients in remission (23.3%) and healthy controls (12.1%, P < 0.001). There were no significant differences in anxiety rates. HD patients and haematological patients undergoing chemotherapy were most likely to be depressed (33.3% and 25%), compared with 16.7% of KTR, 20% of haematological patients in remission and 8.6% of healthy controls (P = 0.066). KTR reported the largest positive health change (+27%, P < 0.001), but still had a lower overall QoL than healthy controls, comparable to haematological patients in remission. HD and chemotherapy patients reported the lowest QoL scores. Fatigue and depression are common in HD patients, resulting in a low QoL, comparable to haematological patients receiving chemotherapy. KTR do better, with scores similar to patients with a haematological malignancy in remission, but still have a lower QoL than healthy controls.
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ISSN:1460-2385
1460-2385
DOI:10.1093/ndt/gfy103