Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism

Serum autoantibodies against eye muscle antigens are closely linked with thyroid-associated ophthalmopathy (TAO), although their significance is unclear. The two antigens that are most often recognized are eye muscle membrane proteins with molecular masses of 55 and 64 kDa, as determined from immuno...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 85; no. 4; p. 1641
Main Authors:	Gunji, K, De Bellis, A, Li, A W, Yamada, M, Kubota, S, Ackrell, B, Wengrowicz, S, Bellastella, A, Bizzarro, A, Sinisi, A, Wall, J R
Format:	Journal Article
Language:	English
Published:	United States 01.04.2000
Subjects:	Adult Amino Acid Sequence Autoantibodies - blood Autoantibodies - immunology Blotting, Western Cloning, Molecular Diabetes Mellitus, Type 1 - immunology Enzyme-Linked Immunosorbent Assay Eye Proteins Female Graves Disease - immunology Humans Male Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - immunology Middle Aged Molecular Sequence Data Oculomotor Muscles - chemistry RNA, Messenger - analysis Thyroid Gland - chemistry Thyroiditis, Autoimmune - immunology
ISSN:	0021-972X
Online Access:	Get more information
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