Involvement of Galectin-1 Tumor Microenvironment in Radiosensitivity

The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Anticancer research Jg. 41; H. 5; S. 2321 - 2331
Hauptverfasser: CHEN, YI-FAN, WANG, CHUNG-CHI, HSU, CHIEH-YING, HUANG, ENG-YEN
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Greece International Institute of Anticancer Research 01.05.2021
Schlagworte:
Antibodies
Antigens
Cancer therapies
Cells
Extracellular matrix
Galectin-1
Immunohistochemistry
Irradiation
Laboratory animals
Lung cancer
Lymphocytes
Lymphocytes B
Lymphocytes T
Melanoma
Radiation
Radiation tolerance
Radioresistance
Radiosensitivity
Radiosensitization
Tumor microenvironment
Tumors
Viral infections
United States > US
Taiwan
Galectin-1
radiosensitivity
tumor microenvironment
ISSN:0250-7005, 1791-7530, 1791-7530
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tumor model. Wild-type or stable galectin-1-down-regulated cancer cells (melanoma (B16F10) and lung cancer (LLC1)) were injected (subcutaneous injection) into wild-type or knockout (galectin-1, B cells, and T cells) mice that were subject to 0 or 8 Gy irradiation. Galectin-1-down-regulated B16F10 cells showed increased radiosensitivity when injected into galectin-1 knockout mice. Interestingly, radioresistance of wild-type LCC1 tumors was noted when injected into galectin-1 and B cell knockout mice. However, radiosensitization was observed in T cell knockout mice with wild-type LCC1 cells. The role of endogenous galectin-1 in radioresistance exists in cases without extracellular galectin-1. Extracellular galectin-1 requires endogenous galectin-1 to radiosensitize tumors in mice.
AbstractList Background/Aim: The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tumor model. Materials and Methods: Wild-type or stable galectin-1-down-regulated cancer cells (melanoma (B16F10) and lung cancer (LLC1)) were injected (subcutaneous injection) into wild-type or knockout (galectin-1, B cells, and T cells) mice that were subject to 0 or 8 Gy irradiation. Results: Galectin-1-down-regulated B16F10 cells showed increased radiosensitivity when injected into galectin-1 knockout mice. Interestingly, radioresistance of wild-type LCC1 tumors was noted when injected into galectin-1 and B cell knockout mice. However, radiosensitization was observed in T cell knockout mice with wild-type LCC1 cells. Conclusion: The role of endogenous galectin-1 in radioresistance exists in cases without extracellular galectin-1. Extracellular galectin-1 requires endogenous galectin-1 to radiosensitize tumors in mice.
The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tumor model. Wild-type or stable galectin-1-down-regulated cancer cells (melanoma (B16F10) and lung cancer (LLC1)) were injected (subcutaneous injection) into wild-type or knockout (galectin-1, B cells, and T cells) mice that were subject to 0 or 8 Gy irradiation. Galectin-1-down-regulated B16F10 cells showed increased radiosensitivity when injected into galectin-1 knockout mice. Interestingly, radioresistance of wild-type LCC1 tumors was noted when injected into galectin-1 and B cell knockout mice. However, radiosensitization was observed in T cell knockout mice with wild-type LCC1 cells. The role of endogenous galectin-1 in radioresistance exists in cases without extracellular galectin-1. Extracellular galectin-1 requires endogenous galectin-1 to radiosensitize tumors in mice.
The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tumor model.BACKGROUND/AIMThe mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tumor model.Wild-type or stable galectin-1-down-regulated cancer cells (melanoma (B16F10) and lung cancer (LLC1)) were injected (subcutaneous injection) into wild-type or knockout (galectin-1, B cells, and T cells) mice that were subject to 0 or 8 Gy irradiation.MATERIALS AND METHODSWild-type or stable galectin-1-down-regulated cancer cells (melanoma (B16F10) and lung cancer (LLC1)) were injected (subcutaneous injection) into wild-type or knockout (galectin-1, B cells, and T cells) mice that were subject to 0 or 8 Gy irradiation.Galectin-1-down-regulated B16F10 cells showed increased radiosensitivity when injected into galectin-1 knockout mice. Interestingly, radioresistance of wild-type LCC1 tumors was noted when injected into galectin-1 and B cell knockout mice. However, radiosensitization was observed in T cell knockout mice with wild-type LCC1 cells.RESULTSGalectin-1-down-regulated B16F10 cells showed increased radiosensitivity when injected into galectin-1 knockout mice. Interestingly, radioresistance of wild-type LCC1 tumors was noted when injected into galectin-1 and B cell knockout mice. However, radiosensitization was observed in T cell knockout mice with wild-type LCC1 cells.The role of endogenous galectin-1 in radioresistance exists in cases without extracellular galectin-1. Extracellular galectin-1 requires endogenous galectin-1 to radiosensitize tumors in mice.CONCLUSIONThe role of endogenous galectin-1 in radioresistance exists in cases without extracellular galectin-1. Extracellular galectin-1 requires endogenous galectin-1 to radiosensitize tumors in mice.
Author CHEN, YI-FAN
HUANG, ENG-YEN
HSU, CHIEH-YING
WANG, CHUNG-CHI
Author_xml – sequence: 1
  givenname: YI-FAN
  surname: CHEN
  fullname: CHEN, YI-FAN
– sequence: 2
  givenname: CHUNG-CHI
  surname: WANG
  fullname: WANG, CHUNG-CHI
– sequence: 3
  givenname: CHIEH-YING
  surname: HSU
  fullname: HSU, CHIEH-YING
– sequence: 4
  givenname: ENG-YEN
  surname: HUANG
  fullname: HUANG, ENG-YEN
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33952457$$D View this record in MEDLINE/PubMed
BookMark eNp90U1LxDAQBuAgiq4fP8CLFLx46TpJmqQ9it-wIoieSzaZQqRNNEkX9t9b1i_w4GkuzzsM8-6TbR88EnJMYc5orfi59tkZ7SOmORUAaovMqGpoqQSHbTIDJqBUAGKP7Kf0CiBlU_Ndssd5I1gl1Ixc3ftV6Fc4oM9F6Ipb3aPJzpe0eB6HEIsHZ2JAv3Ix-A1yvnjS1oWEPrnsVi6vD8lOp_uER1_zgLzcXD9f3pWLx9v7y4tFaVitVMlQVhxFY0xd14Yb1qDCiltKtVadsrzSS6msNrwDsFJSsB1ou6yloFYqww_I2efetxjeR0y5HVwy2PfaYxhTywRjklFgMNHTP_Q1jNFP17WcsaahSlTVpE6-1Lgc0LZv0Q06rtvv_0yAfoLpCSlF7H4IhXbTQfvbQbvpYMqoPxnjss4u-By16_9JfgDso47S
CitedBy_id crossref_primary_10_1080_09553002_2025_2535001
ContentType Journal Article
Copyright Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
– notice: 2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
NPM
3V.
7QO
7RV
7T5
7TM
7TO
7U7
7U9
7X7
7XB
88E
8FD
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
C1K
CCPQU
FR3
FYUFA
GHDGH
H94
K9.
KB0
M0S
M1P
NAPCQ
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
RC3
7X8
DOI 10.21873/anticanres.15007
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Nursing & Allied Health Database
Immunology Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Technology Research Database
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central
Environmental Sciences and Pollution Management
ProQuest One Community College
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Nursing & Allied Health Premium
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
Genetics Abstracts
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
Oncogenes and Growth Factors Abstracts
Technology Research Database
ProQuest One Academic Middle East (New)
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health Research Premium Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
Health & Medical Research Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
Toxicology Abstracts
ProQuest One Academic Eastern Edition
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Oncogenes and Growth Factors Abstracts
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7RV
  name: Nursing & Allied Health Database (ProQuest)
  url: https://search.proquest.com/nahs
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1791-7530
EndPage 2331
ExternalDocumentID 33952457
10_21873_anticanres_15007
Genre Journal Article
GeographicLocations United States--US
Taiwan
GeographicLocations_xml – name: Taiwan
– name: United States--US
GroupedDBID ---
.55
.GJ
23M
53G
5GY
5RE
5VS
7RV
7X7
88E
8FI
8FJ
AAYXX
ABUWG
ADBBV
AENEX
AFFHD
AFFNX
AFKRA
AIZAD
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BENPR
BTFSW
CCPQU
CITATION
DIK
EBS
EJD
F5P
FYUFA
H13
HMCUK
KQ8
L7B
M1P
NAPCQ
OK1
P2P
PHGZM
PHGZT
PJZUB
PPXIY
PSQYO
RHI
SJN
UDS
UKHRP
VRB
W8F
X7M
ZGI
ZXP
NPM
RHF
3V.
7QO
7T5
7TM
7TO
7U7
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
P64
PKEHL
PQEST
PQQKQ
PQUKI
RC3
7X8
ID FETCH-LOGICAL-c2877-2e643e59cc888c3c29e7e43d11aa7f7d34ab67dac3f00d6610df0adb8651d67c3
IEDL.DBID 7RV
ISSN 0250-7005
1791-7530
IngestDate Fri Sep 05 10:00:23 EDT 2025
Tue Nov 11 13:10:45 EST 2025
Wed Feb 19 02:29:30 EST 2025
Sat Nov 29 03:36:07 EST 2025
Tue Nov 18 22:29:02 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Galectin-1
radiosensitivity
tumor microenvironment
Language English
License Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c2877-2e643e59cc888c3c29e7e43d11aa7f7d34ab67dac3f00d6610df0adb8651d67c3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://ar.iiarjournals.org/content/anticanres/41/5/2321.full.pdf
PMID 33952457
PQID 3229917544
PQPubID 2049060
PageCount 11
ParticipantIDs proquest_miscellaneous_2522621020
proquest_journals_3229917544
pubmed_primary_33952457
crossref_primary_10_21873_anticanres_15007
crossref_citationtrail_10_21873_anticanres_15007
PublicationCentury 2000
PublicationDate 2021-05-00
2021-May
20210501
PublicationDateYYYYMMDD 2021-05-01
PublicationDate_xml – month: 05
  year: 2021
  text: 2021-05-00
PublicationDecade 2020
PublicationPlace Greece
PublicationPlace_xml – name: Greece
– name: Athens
PublicationTitle Anticancer research
PublicationTitleAlternate Anticancer Res
PublicationYear 2021
Publisher International Institute of Anticancer Research
Publisher_xml – name: International Institute of Anticancer Research
SSID ssj0066983
Score 2.3336668
Snippet The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the...
Background/Aim: The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be...
SourceID proquest
pubmed
crossref
SourceType Aggregation Database
Index Database
Enrichment Source
StartPage 2321
SubjectTerms Antibodies
Antigens
Cancer therapies
Cells
Extracellular matrix
Galectin-1
Immunohistochemistry
Irradiation
Laboratory animals
Lung cancer
Lymphocytes
Lymphocytes B
Lymphocytes T
Melanoma
Radiation
Radiation tolerance
Radioresistance
Radiosensitivity
Radiosensitization
Tumor microenvironment
Tumors
Viral infections
Title Involvement of Galectin-1 Tumor Microenvironment in Radiosensitivity
URI https://www.ncbi.nlm.nih.gov/pubmed/33952457
https://www.proquest.com/docview/3229917544
https://www.proquest.com/docview/2522621020
Volume 41
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Health & Medical Collection (ProQuest)
  customDbUrl:
  eissn: 1791-7530
  dateEnd: 20231209
  omitProxy: false
  ssIdentifier: ssj0066983
  issn: 0250-7005
  databaseCode: 7X7
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database (ProQuest)
  customDbUrl:
  eissn: 1791-7530
  dateEnd: 20231209
  omitProxy: false
  ssIdentifier: ssj0066983
  issn: 0250-7005
  databaseCode: 7RV
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1791-7530
  dateEnd: 20231209
  omitProxy: false
  ssIdentifier: ssj0066983
  issn: 0250-7005
  databaseCode: BENPR
  dateStart: 20180101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB61UFVcoC_oAkWp1FMlC8eO7eSEeLaVygqtaLW3yLEdaaU2oZvd_v7OONmFS7lw8SVvz3jmG89kPoBPqdXCCwxLVKUyluW-ZpUOktVeaeMqFbiPrCXfzXicT6fFzbDh1g1llSubGA21bx3tkR-j4iGUoXZtJ3d_GLFGUXZ1oNB4DpspYWPUZzP5ubLEWhd9G05088yguvVZTXRqRh7je5OdmVPtkeLEJvvQL_0HbEanc7Xz1Nd9BdsD3ExOe_14Dc9C8wZeXg8J9bdw8a1B-xR7hi-Stk6-WNrGnzUsTW6Xv9t5ck0Few_-hktmTTKxftZ2VPneU0-8gx9Xl7fnX9lArMAcBkiGiYA4JKjCOYx_nXSiCCZk0qeptaY2Xma20sZbJ2vOPXpw7mtufZVrlXoUodyFjaZtwntIEG2I4HOunRGZ8kVuaysql_MgnNYqjICvprV0Q9dxIr_4VWL0ESVR3kuijJIYwef1JXd9y43HTj5czX85rL6uvJ_8EXxcH8Z1Q8kQ24R22ZWCgCfFu3wEe72M10-TslD4NWb_8ZsfwJagCpdY_ngIG4v5MnyAF-7vYtbNj6Iq0jg1ccyPYPPscnwz-Qe_7Ox_
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB61BQEXyqOFhRaMBBckq44d28kBIdQHXXV3hdAi7S11bEdaCZKy2QXxp_iNjPPY9kJvPfScxIn9TWbm84xnAN5GRnHHkZbIXMY0TlxBc-UFLZxU2ubSM9d0LRnpySSZzdIvG_C3PwsT0ip7ndgoalfZsEd-gIKHrkwo1_bx4icNXaNCdLVvodGKxZn_8xspW_1heIT4vuP85Hh6eEq7rgLUIjvQlHs0wl6m1iL5s8Ly1GsfCxdFxuhCOxGbXGlnrCgYc2i-mCuYcXmiZOTw-wWOuwl3UI_rQPb0bE3wlErbsp_oVlCN4t1GUdGIanGA6xT02iLkOkkWutdetYP_cW4bI3eyfduW5xE87Nxp8qmV_8ew4csncG_cJQw8haNhifq3qYm-JFVBPpsQppiXNCLT1Y9qQcYhIfHKaT8yL8lX4-ZVHTL729YaO_DtRuawC1tlVfrnQNCb4t4lTFnNY-nSxBSG5zZhnlulpB8A62HMbFdVPTT3-J4hu2qQzy6RzxrkB_B-_chFW1Lkupv3eryzTrvU2SXYA3izvox6IQR7TOmrVZ3x4FgHPs8G8KyVqfXbhEglzka_uH7w13D_dDoeZaPh5OwlPOAhm6dJ9dyDreVi5ffhrv21nNeLV81vQOD8pgXrH5yURpU
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Involvement+of+Galectin-1+Tumor+Microenvironment+in+Radiosensitivity&rft.jtitle=Anticancer+research&rft.au=Yi-Fan%2C+Chen&rft.au=Chung-Chi%2C+Wang&rft.au=Hsu%2C+Chieh-Ying&rft.au=Eng-Yen%2C+Huang&rft.date=2021-05-01&rft.pub=International+Institute+of+Anticancer+Research&rft.issn=0250-7005&rft.eissn=1791-7530&rft.volume=41&rft.issue=5&rft.spage=2321&rft_id=info:doi/10.21873%2Fanticanres.15007
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0250-7005&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0250-7005&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0250-7005&client=summon