Photoprotection and its implications for drug safety

Appropriate photoprotection plays a key role in the safety of using medicinal preparations whose active substances may induce photosensitivity reactions. This aspect applies not only to drugs applied topically to the skin, but also systemically. Drug-induced photosensitivity reactions to light depen...

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Veröffentlicht in:Medycyna pracy Jg. 75; H. 5; S. 475 - 484
Hauptverfasser: Kryczyk-Poprawa, Agata, Czarnecki, Grzegorz, Jaśkiewicz, Katarzyna
Format: Journal Article
Sprache:Englisch
Polnisch
Veröffentlicht: Poland Nofer Institute of Occupational Medicine 28.11.2024
Schlagworte:
drug safety
health promotion
photoprotection
photosensitivity
safe pharmacotherapy
skin cancer
photoprotection
skin cancer
health promotion
safe pharmacotherapy
photosensitivity
drug safety
ISSN:0465-5893, 2353-1339, 2353-1339
Online-Zugang:Volltext
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Zusammenfassung:Appropriate photoprotection plays a key role in the safety of using medicinal preparations whose active substances may induce photosensitivity reactions. This aspect applies not only to drugs applied topically to the skin, but also systemically. Drug-induced photosensitivity reactions to light depend on the active substance contained in the medicinal product and its dose, which translates into the concentration in the skin, the type of ultraviolet radiation, its intensity and exposure time. The chemical structure of phototoxic drugs contains unsaturated chemical bonds and aromatic groups, which are responsible for the absorption of radiation, the formation of degradation products and/or free radicals and hypersensitivity reactions. Therefore, in order to prevent hypersensitivity reactions, it is necessary to use appropriate sun protection and/or avoid exposure to solar radiation during pharmacotherapy with selected groups of drugs. The paper presents the latest research results on the impact of drug-induced photohypersensitivity on the increased likelihood of skin cancer. Drugs with the potential to induce photohypersensitivity reactions are discussed, including information on the relationship between their long-term use and the incidence of skin cancer. Based on the data contained in the Product Characteristics, exemplary indications regarding the appropriate photoprotection method to ensure the safe use of the medicinal product are presented. Med Pr Work Health Saf. 2024;75(5).
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0465-5893
2353-1339
2353-1339
DOI:10.13075/mp.5893.01560