PEGylated anticancer-carbon nanotubes complex targeting mitochondria of lung cancer cells

Although activating apoptosis in cancer cells by targeting the mitochondria is an effective strategy for cancer therapy, insufficient targeting of the mitochondria in cancer cells restricts the availability in clinical treatment. Here, we report on a polyethylene glycol-coated carbon nanotube-ABT737...

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Bibliographic Details
Published in:Nanotechnology Vol. 28; no. 46; p. 465102
Main Authors: Kim, Sang-Woo, Lee, Yeon Kyung, Lee, Jong Yeon, Hong, Jeong Hee, Khang, Dongwoo
Format: Journal Article
Language:English
Published: England 17.11.2017
Subjects:
non-small cell lung cancer
ABT-737
mitochondria
anticancer efficacy
ISSN:1361-6528, 1361-6528
Online Access:Get more information
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Summary:Although activating apoptosis in cancer cells by targeting the mitochondria is an effective strategy for cancer therapy, insufficient targeting of the mitochondria in cancer cells restricts the availability in clinical treatment. Here, we report on a polyethylene glycol-coated carbon nanotube-ABT737 nanodrug that improves the mitochondrial targeting of lung cancer cells. The polyethylene glycol-coated carbon nanotube-ABT737 nanodrug internalized into the early endosomes via macropinocytosis and clathrin-mediated endocytosis in advance of early endosomal escape and delivered into the mitochondria. Cytosol release of nanodrug led to apoptosis of lung cancer cells by abruption of the mitochondrial membrane potential, inducing Bcl-2-mediated apoptosis and generating intracellular reactive oxygen species. As such, this study provides an effective strategy for increasing the anti-lung cancer efficacy by increasing mitochondria accumulation rate of cytosol released anticancer nanodrugs.
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ISSN:1361-6528
1361-6528
DOI:10.1088/1361-6528/aa8c31