ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway

The malignant progression of colorectal cancer (CRC) is closely related to cell stemness, but its regulatory mechanism has not been fully elucidated. This study found that ADAMTS14 was significantly highly expressed in CRC tissues and cell lines and was associated with poor prognosis in patients. Fu...

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Bibliographic Details
Published in:	Human cell : official journal of Human Cell Research Society Vol. 39; no. 1; p. 7
Main Authors:	Jiang, Yicheng, Tan, Xingping
Format:	Journal Article
Language:	English
Published:	Japan Springer Nature B.V 12.11.2025
Subjects:	ADAMTS Proteins - genetics ADAMTS Proteins - metabolism Bioinformatics Cell Line, Tumor Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Gene Expression Regulation, Neoplastic - genetics Humans Liver cancer Medical prognosis Metastasis Mortality Neoplastic Stem Cells - pathology Penicillin Plasmids Prognosis Signal transduction Stem cells Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Treatment resistance Wnt protein Wnt Signaling Pathway - genetics United States > US China Germany ADAMTS14 Cell stemness Wnt signaling pathway ONECUT2 Colorectal cancer
ISSN:	1749-0774, 0914-7470, 1749-0774
Online Access:	Get full text
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