Breaking Boundaries in Histone Modification MS-Based Detection: A Tailored Search Strategy for Unrestricted Identification of Novel Epigenetic Marks

Histone post-translational modifications (PTMs) play a crucial role in regulating gene expression and maintaining DNA integrity, and their aberrations are linked to various diseases, including cancer. While lysine acetylation and methylation have been extensively studied, recent research has uncover...

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Veröffentlicht in:	Molecular & cellular proteomics Jg. 24; H. 11; S. 101080
Hauptverfasser:	Vai, Alessandro, Noberini, Roberta, Graziadei, Andrea, Polasky, Daniel A., Yu, Fengchao, Nesvizhskii, Alexey I., Bonaldi, Tiziana
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.11.2025
Schlagworte:	bioinformatics workflow epigenetics histone PTM discovery mass spectrometry post-translational modifications pr OS MS DMO PTM K PIC PSM PRO epigenetics bioinformatics workflow HiP-Frag R FDR LC mass spectrometry me3 post-translational modifications FA DIA histone PTM discovery AGE
ISSN:	1535-9476, 1535-9484, 1535-9484
Online-Zugang:	Volltext
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