Validation of an Automated Urea Assay Method Using Bronchoalveolar Lavage Fluid Samples for the Therapeutic Drug Monitoring of Antimicrobials in Severe Pneumonia

Determining the concentration of an antimicrobial agent in epithelial lining fluid using therapeutic drug monitoring (TDM) may be clinically useful for optimizing drug exposure in patients with severe pneumonia. The epithelial lining fluid drug concentration can be measured in samples obtained durin...

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Veröffentlicht in:	Therapeutic drug monitoring Jg. 47; H. 5; S. 682
Hauptverfasser:	Ghaleb, Maeva, Delomez, Julia, Sauzay, Chloé, Durand-Maugard, Charlotte, Bodeau, Sandra, Huriez, Elisabeth, Preudhomme, Maite, Lemaire-Hurtel, Anne-Sophie, Andréjak, Claire, Bennis, Youssef
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2025
Schlagworte:	Aged Anti-Infective Agents - therapeutic use Bronchoalveolar Lavage Fluid - chemistry Drug Monitoring - methods Female Humans Male Middle Aged Pneumonia - drug therapy Pneumonia - metabolism Prospective Studies Reproducibility of Results Urea - analysis Urea - blood antimicrobials pharmacokinetics epithelial lining fluid pneumonia lung penetration therapeutic drug monitoring
ISSN:	1536-3694, 1536-3694
Online-Zugang:	Weitere Angaben
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