Continuous 24-hour intravenous infusion of recombinant human growth hormone (GH)-releasing hormone-(1-44)-amide augments pulsatile, entropic, and daily rhythmic GH secretion in postmenopausal women equally in the estrogen-withdrawn and estrogen-supplemented states

How estrogen amplifies GH secretion in the human is not known. The present study tests the clinical hypothesis that estradiol modulates the stimulatory actions of a primary GH feedforward signal, GHRH. To this end, we investigated the ability of short-term (7- to 12-day) supplementation with oral es...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 86; no. 2; p. 700
Main Authors:	Evans, W S, Anderson, S M, Hull, L T, Azimi, P P, Bowers, C Y, Veldhuis, J D
Format:	Journal Article
Language:	English
Published:	United States 01.02.2001
Subjects:	Aged Circadian Rhythm - drug effects Circadian Rhythm - physiology Entropy Estradiol - pharmacology Estrogen Replacement Therapy Female Growth Hormone-Releasing Hormone - administration & dosage Growth Hormone-Releasing Hormone - analogs & derivatives Growth Hormone-Releasing Hormone - pharmacology Half-Life Human Growth Hormone - blood Human Growth Hormone - secretion Humans Infusions, Intravenous Middle Aged Models, Biological Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Placebos Postmenopause - blood Postmenopause - physiology Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology Regression Analysis
ISSN:	0021-972X
Online Access:	Get more information
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