First bioconjugates in the role of highly effective human dihydroorotate dehydrogenase inhibitors: Synthesis, pharmacological, toxicological and hydrolytic stability studies of α-amino acid-modified pyrrolo[3,4-c]quinoline-1,3-dione scaffold

Human dihydroorotate dehydrogenase (hDHODH) represents an attractive target for the treatment of cancer, diabetes, anti-infective and autoimmune diseases. In drug development, hDHODH inhibitors with great potency, good chemical stability and low toxicity open the broad therapeutic perspectives. Acco...

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Bibliographic Details
Published in:	European journal of medicinal chemistry Vol. 297; p. 117972
Main Authors:	Dimitrijević, Marina G., Roschger, Cornelia, Kehrer, Stefanie, Zierer, Andreas, Paunović, Milica G., Obradović, Ana D., Matić, Miloš M., Klarić, David, Galić, Nives, Ćirić, Andrija, Joksović, Ljubinka, Petković, Miloš, Joksović, Milan D.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 05.11.2025
Subjects:	Amino Acids - chemistry Amino Acids - pharmacology Animals Bioconjugates Cell Line Dihydroorotate Dehydrogenase Dose-Response Relationship, Drug Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology hDHODH inhibitors Humans Hydrolysis Male Molecular Docking Simulation Molecular Structure Oxidoreductases Acting on CH-CH Group Donors - antagonists & inhibitors Oxidoreductases Acting on CH-CH Group Donors - metabolism Pyrroles - chemical synthesis Pyrroles - chemistry Pyrroles - pharmacology pyrrolo[3,4-c]quinolines Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Rats Structure-Activity Relationship α-Amino acids hDHODH inhibitors α-Amino acids pyrrolo[3,4-c]quinolines Bioconjugates Dihydroorotate dehydrogenase
ISSN:	0223-5234, 1768-3254
Online Access:	Get full text
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